References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2014-2-103-113

vtio-230

Research Article

Обзор литературы

Literature Reviews

ТКАНЕВАЯ ИНЖЕНЕРИЯ ПЕЧЕНИ (СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ ПО ДАННЫМ ЗАРУБЕЖНЫХ ИСТОЧНИКОВ)

HEPATIC TISSUE ENGINEERING (MODERN STATE OF THIS PROBLEM)

Гулай

Ю.С.

Gulay

Y.S.

студентка-дипломница факультета фундаментальной медицины МГУ имени М.В. Ломоносова, Москва, РФ

Крашенинников

М.Е.

Krasheninnikov

M.E.

к. б. н., старший научный сотрудник лабораториии клеточных технологий отдела биомедицинских технологий и тканевой инженерии ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени акад. В.И. Шумакова"

Шагидулин

М.Ю

Shagidulin

M.Y.

к. м. н., заведующий отделом экспериментальной трансплантологии и искусственных органов ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени акад. В.И. Шумакова"

доцент кафедры трансплантологии и искусственных органов ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова», Москва, РФ

Онищенко

Н.А.

Onishchenko

N.A.

д. м. н., проф., зав. лабораторией клеточных технологий отдела биомедицинских технологий и тканевой инженерии ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени акад. В.И. Шумакова"

МГУ имени М.В. Ломоносова, МоскваРоссияM.V. Lomonosov Moscow State UniversityRussian Federation

ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени акад. В.И. Шумакова» Минздрава РФ, МоскваРоссияV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs, Moscow, Russian FederationRussian Federation

ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени акад. В.И. Шумакова» Минздрава РФ, Москва ГБОУ ВПО «Первый МГМУ им. И.М. Сеченова», МоскваРоссияV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationRussian Federation

2014

29052014

162

ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XVI No 2–2014

103113

2014

Гулай Ю., Крашенинников М., Шагидулин М., Онищенко Н.

Gulay Y., Krasheninnikov M., Shagidulin M., Onishchenko N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/230

В статье рассматривается проблема создания имплантируемых тканеинженерных конструкций печени как современный этап комплексных исследований по созданию биоискусственной печени. Позитивное решение многочисленных биологических и технологических проблем, стоящих на пути создания таких конструкций, включает разработку и использование матриксов с заданными свойствами, имитирующими свойства печеночного внеклеточного матрикса; применение технологий стереотипического заселения этих матриксов как паренхиматозными, так и непаренхиматозными клетками печени и совершенствование технологий изготовления и сборки тканеинженерных конструкций печени.

In this article it was discussed the problem of creation implanted hepatic tissue engineering designs as a modern stage of complex investigation for working out bioartifi cial liver support systems. It was determined that for the positive decision of numerous biological and technological problems it is necessary: to use matrices with determined properties, which mimic properties of hepatic extracellular matrix; to use technology for stereotype sowing of these matrices by both parenchymal and non-parenchymal hepatic cells and to improve the technologies for making and assembling of hepatic tissue-engineering designs.

клетки печениматриксытканеинженерные конструкции

liver cellsmatricestissue-engineering design

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The authors declare that there are no conflicts of interest present.