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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2026-2-263-272</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-2094</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРГАНИЗАЦИЯ ТРАНСПЛАНТОЛОГИЧЕСКОЙ ПОМОЩИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORGANIZATION OF TRANSPLANT CARE</subject></subj-group></article-categories><title-group><article-title>Развитие программы трансплантации почки в Узбекистане: анализ и перспективы многолетней хирургической активности</article-title><trans-title-group xml:lang="en"><trans-title>Development of the kidney transplant program in Uzbekistan: a multi-year analysis of surgical activity and future perspectives</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмаилов</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ismailov</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ташкент</p></bio><bio xml:lang="en"><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бахритдинов</surname><given-names>Ф. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakhritdinov</surname><given-names>F. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ташкент</p></bio><bio xml:lang="en"><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суюмов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Suyumov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ташкент</p></bio><bio xml:lang="en"><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-0618-6752</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдугафуров</surname><given-names>З. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdugafurov</surname><given-names>Z. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абдугафуров Зафарбек Улугбекович - хирург отделения хирургии сосудов и трансплантации почки, руководитель отдела международных связей и развития медицинского туризма.</p><p>100115, Ташкент, ул. Кичик Халқа Йули, д. 10</p><p>Тел. +998901120010</p></bio><bio xml:lang="en"><p>Zafarbek U. Abdugafurov.</p><p>10, Kichik Khalka Yuli str., Tashkent, 100115</p><p>Phone: +998901120010</p></bio><email xlink:type="simple">zafarbek1992@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУ «Республиканский специализированный научно-практический медицинский центр хирургии имени академика В. Вахидова»</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Republican Specialized Scientific and Practical Medical Center of Surgery</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2026</year></pub-date><volume>28</volume><issue>2</issue><fpage>263</fpage><lpage>272</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Исмаилов С.И., Бахритдинов Ф.Ш., Суюмов А.С., Абдугафуров З.У., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Исмаилов С.И., Бахритдинов Ф.Ш., Суюмов А.С., Абдугафуров З.У.</copyright-holder><copyright-holder xml:lang="en">Ismailov S.I., Bakhritdinov F.S., Suyumov A.S., Abdugafurov Z.U.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/2094">https://journal.transpl.ru/vtio/article/view/2094</self-uri><abstract><p>На протяжении последних двух десятилетий трансплантация почки в Узбекистане развивалась неравномерно, проходя несколько этапов становления. Целью работы стало проследить эти изменения, оценив, как менялся объем операций, где они выполнялись, и каким образом организовано наблюдение за пациентами после трансплантации. Материалы и методы. В исследование включены 2803 пациента, перенесшие трансплантацию почки с 2007-го по июль 2025 года. Анализ проводился на основе регистра получателей иммуносупрессивной терапии и данных медицинских учреждений различных уровней. Рассматривались ежегодные показатели трансплантаций, география выполнения операций, вклад отдельных центров, а также распределение пациентов по регионам реабилитации. Результаты. Установлено, что рост хирургической активности внутри страны стал заметным лишь после 2017 года, а наиболее выраженное увеличение числа операций пришлось на период 2021–2024 годов. За это время трансплантация почки в Узбекистане превратилась из редкой высокотехнологичной процедуры в рутинную помощь, выполняемую преимущественно в национальных центрах. Основная доля операций выполнялась в Республиканском специализированном научно-практическом медицинском центре хирургии имени академика В. Вахидова. Наряду с этим выявлены значительные различия между регионами: большинство пациентов продолжают наблюдаться в столице, тогда как роль областных учреждений лишь начинает усиливаться. Заключение. Полученные данные демонстрируют формирование стабильной национальной программы трансплантации почки, при этом региональная система посттрансплантационного наблюдения остается неоднородной. Расширение возможностей областных и районных учреждений, развитие телемедицинских сервисов и подготовка кадров могут повысить доступность специализированной помощи и снизить нагрузку на центральные клиники.</p></abstract><trans-abstract xml:lang="en"><p>Over the past two decades, kidney transplantation (KT) in Uzbekistan has developed unevenly, passing through several stages of growth. Objective: to evaluate these developments by analyzing changes in the volume of transplant procedures, their geographic distribution, and the organization of post-transplant patient follow-up. Materials and methods. The study included 2,803 patients who underwent KT between 2007 and July 2025. Data were obtained from the national registry of recipients of immunosuppressive therapy, as well as from medical institutions at various levels of care. The analysis focused on annual transplant rates, geographic distribution of surgeries, the contribution of individual transplant centers, and the regional distribution of patients during the rehabilitation period. Results. An increase in surgical activity in Uzbekistan became evident only after 2017, with the most pronounced growth in the number of KT procedures observed between 2021 and 2024. During this period, KT transitioned from a rare, high-tech procedure to a routine clinical intervention performed primarily at national transplant centers. The majority of transplantations were carried out at Republican Specialized Scientific and Practical Medical Center of Surgery. At the same time, significant regional disparities were identified: most patients continue to receive care in the capital city, while the involvement of regional healthcare institutions remains limited but gradually increasing. Conclusion. The findings indicate the formation of a stable national KT program in Uzbekistan; however, the system of post-transplant follow-up across regions remains inconsistent. Strengthening the capacity of regional and district healthcare facilities, expanding telemedicine services, and enhancing personnel training may improve access to specialized care and reduce the workload on central transplant centers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация почки</kwd><kwd>Узбекистан</kwd><kwd>хирургическая активность</kwd><kwd>реабилитация</kwd><kwd>региональная доступность</kwd><kwd>специализированная помощь</kwd></kwd-group><kwd-group xml:lang="en"><kwd>kidney transplantation</kwd><kwd>Uzbekistan</kwd><kwd>surgical activity</kwd><kwd>rehabilitation</kwd><kwd>regional accessibility</kwd><kwd>specialized care</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Готье СВ. Векторы отечественной трансплантологии: развитие технологий, трансляция в регионы. Вестник трансплантологии и искусственных органов. 2025; 27 (2): 6–7.</mixed-citation><mixed-citation xml:lang="en">Gautier SV. Advancing transplantology in Russia: innovation pathways and regional deployment. Russian Journal of Transplantology and Artificial Organs. 2025; 27 (2): 6–7.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Готье СВ. Сложнейшие трансплантации органов перестали быть прерогативой столичных клиник. Российская газета. 2024; 11 января. Доступно по: https://rg.ru/2024/01/11/obyknovennoe-chudo.html.</mixed-citation><mixed-citation xml:lang="en">Gauthier SV. Complex organ transplants are no longer the preserve of capital clinics. Rossiyskaya Gazeta. 2024; January 11. Доступно по/Available at: https://rg.ru/2024/01/11/obyknovennoe-chudo.html.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Axelrod DA, Guidinger MK, McCullough KP, Leichtman AB, Punch JD, Merion RM. Association of center volume with outcome after liver and kidney transplantation. Am J Transplant. 2004; 4 (6): 920–927. doi: 10.1111/j.1600-6143.2004.00462.x.</mixed-citation><mixed-citation xml:lang="en">Axelrod DA, Guidinger MK, McCullough KP, Leichtman AB, Punch JD, Merion RM. Association of center volume with outcome after liver and kidney transplantation. Am J Transplant. 2004; 4 (6): 920–927. doi: 10.1111/j.1600-6143.2004.00462.x.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Azhar A, Defor E, Bandyopadhyay D, Kamal L, Tanriover B, Gupta G. Long-term effects of center volume on transplant outcomes in adult kidney transplant recipients. PLoS One. 2024; 19 (6): e0301425. doi: 10.1371/journal.pone.0301425.</mixed-citation><mixed-citation xml:lang="en">Azhar A, Defor E, Bandyopadhyay D, Kamal L, Tanriover B, Gupta G. Long-term effects of center volume on transplant outcomes in adult kidney transplant recipients. PLoS One. 2024; 19 (6): e0301425. doi: 10.1371/journal.pone.0301425.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Babloyan S, Voskanyan M, Shekherdimian S, Nazaryan H, Arakelyan S, Kurkchyan K et al. Kidney transplantation in low-to middle-income countries: outcomes and lessons learned from Armenia. Ann Transplant. 2021; 26: e930943. doi: 10.12659/AOT.930943.</mixed-citation><mixed-citation xml:lang="en">Babloyan S, Voskanyan M, Shekherdimian S, Nazaryan H, Arakelyan S, Kurkchyan K et al. Kidney transplantation in low-to middle-income countries: outcomes and lessons learned from Armenia. Ann Transplant. 2021; 26: e930943. doi: 10.12659/AOT.930943.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Boenink R, Kramer A, Masoud S, Rodríguez‑Benot A, Helve J, Bistrup C et al. International comparison and time trends of first kidney transplant recipient characteristics across Europe: an ERA Registry study. Nephrol Dial Transplant. 2024; 39 (4): 648–658. doi: 10.1093/ndt/gfad189.</mixed-citation><mixed-citation xml:lang="en">Boenink R, Kramer A, Masoud S, Rodríguez‑Benot A, Helve J, Bistrup C et al. International comparison and time trends of first kidney transplant recipient characteristics across Europe: an ERA Registry study. Nephrol Dial Transplant. 2024; 39 (4): 648–658. doi: 10.1093/ndt/gfad189.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Contento MN, Vercillo RN, Malaga‑Dieguez L, Pehrson LJ, Wang Y, Liu M et al. Center volume and kidney transplant outcomes in pediatric patients. Kidney Med. 2020; 2 (3): 297–306. doi: 10.1016/j.xkme.2020.01.008.</mixed-citation><mixed-citation xml:lang="en">Contento MN, Vercillo RN, Malaga‑Dieguez L, Pehrson LJ, Wang Y, Liu M et al. Center volume and kidney transplant outcomes in pediatric patients. Kidney Med. 2020; 2 (3): 297–306. doi: 10.1016/j.xkme.2020.01.008.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Duong NX, Thai MS, Tran NS, Hoang KC, Chau QT, Ngo XT et al. The impact of socioeconomic factors on kidney transplantation: a systematic review of low-and middle-income countries. Soc Int Urol J. 2024; 5 (5): 349–360. doi: 10.3390/siuj5050054.</mixed-citation><mixed-citation xml:lang="en">Duong NX, Thai MS, Tran NS, Hoang KC, Chau QT, Ngo XT et al. The impact of socioeconomic factors on kidney transplantation: a systematic review of low-and middle-income countries. Soc Int Urol J. 2024; 5 (5): 349–360. doi: 10.3390/siuj5050054.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Furia FF, Shoo JG, Ruggajo PJ, Mngumi JW, Gudila V, Muhiddin MA et al. Establishing kidney transplantation in a low-income country: a case in Tanzania. Ren Replace Ther. 2024; 10 (1): 29. doi: 10.1186/s41100-024-00545-z.</mixed-citation><mixed-citation xml:lang="en">Furia FF, Shoo JG, Ruggajo PJ, Mngumi JW, Gudila V, Muhiddin MA et al. Establishing kidney transplantation in a low-income country: a case in Tanzania. Ren Replace Ther. 2024; 10 (1): 29. doi: 10.1186/s41100-024-00545-z.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Global Observatory on Donation and Transplantation (GODT). International report on organ donation and transplantation activities 2020. Madrid: ONT/WHO; 2021. Available at: https://www.transplant-observatory.org.</mixed-citation><mixed-citation xml:lang="en">Global Observatory on Donation and Transplantation (GODT). International report on organ donation and transplantation activities 2020. Madrid: ONT/WHO; 2021. Available at: https://www.transplant-observatory.org.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Guy‑Frank CJ, Persaud K, Butsenko D, Jindal RM, Guy SR. Developing a sustainable renal transplant program in low- and middle-income countries: outcome, challenges, and solutions. World J Surg. 2019; 43 (11): 2658–2665. doi: 10.1007/s00268-019-05093-w.</mixed-citation><mixed-citation xml:lang="en">Guy‑Frank CJ, Persaud K, Butsenko D, Jindal RM, Guy SR. Developing a sustainable renal transplant program in low- and middle-income countries: outcome, challenges, and solutions. World J Surg. 2019; 43 (11): 2658–2665. doi: 10.1007/s00268-019-05093-w.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">International Society of Nephrology. ISN Global Kidney Health Atlas. 3rd ed. Brussels: ISN; 2023. Available at: https://www.theisn.org/initiatives/global-kidney-health-atlas/.</mixed-citation><mixed-citation xml:lang="en">International Society of Nephrology. ISN Global Kidney Health Atlas. 3rd ed. Brussels: ISN; 2023. Available at: https://www.theisn.org/initiatives/global-kidney-health-atlas/.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Merzkani M, Chang SH, Murad H, Lentine KL, Mattu M, Wang M et al. The association of center volume with transplant outcomes in selected high-risk groups in kidney transplantation. BMC Nephrol. 2023; 24 (1): 61. doi: 10.1186/s12882-023-03099-0.</mixed-citation><mixed-citation xml:lang="en">Merzkani M, Chang SH, Murad H, Lentine KL, Mattu M, Wang M et al. The association of center volume with transplant outcomes in selected high-risk groups in kidney transplantation. BMC Nephrol. 2023; 24 (1): 61. doi: 10.1186/s12882-023-03099-0.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Montgomery JR, Sung RS, Woodside KJ. Transplant center volume: is bigger better? Am J Kidney Dis. 2019; 74 (4): 432–434. PMID: 31358310.</mixed-citation><mixed-citation xml:lang="en">Montgomery JR, Sung RS, Woodside KJ. Transplant center volume: is bigger better? Am J Kidney Dis. 2019; 74 (4): 432–434. PMID: 31358310.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nkunu V, Tungsanga S, Diongole HM, Sarki A, Arruebo S, Caskey FJ et al. Landscape of kidney replacement therapy provision in low- and lower-middle income countries: a multinational study from the ISN-GKHA. PLOS Glob Public Health. 2024; 4 (12): e0003979. doi: 10.1371/journal.pgph.0003979.</mixed-citation><mixed-citation xml:lang="en">Nkunu V, Tungsanga S, Diongole HM, Sarki A, Arruebo S, Caskey FJ et al. Landscape of kidney replacement therapy provision in low- and lower-middle income countries: a multinational study from the ISN-GKHA. PLOS Glob Public Health. 2024; 4 (12): e0003979. doi: 10.1371/journal.pgph.0003979.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ramsay AIG, Tomini SM, Gandhi S, Fulop NJ, Morris S. Centralisation of specialised healthcare services: a scoping review of definitions, types, and impact on outcomes. Health Soc Care Deliv Res. 2025; 13 (43): 21–90. doi: 10.3310/REMD6648.</mixed-citation><mixed-citation xml:lang="en">Ramsay AIG, Tomini SM, Gandhi S, Fulop NJ, Morris S. Centralisation of specialised healthcare services: a scoping review of definitions, types, and impact on outcomes. Health Soc Care Deliv Res. 2025; 13 (43): 21–90. doi: 10.3310/REMD6648.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Szymańska A, Mucha K, Kosieradzki M, Nazarewski S, Pączek L, Foroncewicz B. Organization of post-transplant care and the 5-year outcomes of kidney transplantation. Int J Environ Res Public Health. 2022; 19 (4): 2010. doi: 10.3390/ijerph19042010.</mixed-citation><mixed-citation xml:lang="en">Szymańska A, Mucha K, Kosieradzki M, Nazarewski S, Pączek L, Foroncewicz B. Organization of post-transplant care and the 5-year outcomes of kidney transplantation. Int J Environ Res Public Health. 2022; 19 (4): 2010. doi: 10.3390/ijerph19042010.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">United States Renal Data System. 2021 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. Chapter 11: International Comparisons. Bethesda, MD: NIDDK, NIH; 2021. Available at: https://usrds-adr.niddk.nih.gov/2021.</mixed-citation><mixed-citation xml:lang="en">United States Renal Data System. 2021 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. Chapter 11: International Comparisons. Bethesda, MD: NIDDK, NIH; 2021. Available at: https://usrds-adr.niddk.nih.gov/2021.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
