References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2026-2-188-201

vtio-2067

Research Article

РЕГЕНЕРАТИВНАЯ МЕДИЦИНА И КЛЕТОЧНЫЕ ТЕХНОЛОГИИ

REGENERATIVE MEDICINE AND CELL TECHNOLOGIES

Перспективы использования аллогенных бесклеточных тканеинженерных продуктов для коррекции постишемического ремоделирования миокарда

Prospects for allogeneic acellular tissue-engineered products in the management of post-ischemic myocardial remodeling

Афанасьев

С. А.

Afanasiev

S. A.

Афанасьев Сергей Александрович.

634012, Томск, ул. Киевская, д. 111а

Тел. (382) 255-50-57

Sergey A. Afanasiev.

111a, Kievskaya str., Tomsk, 634012

Phone: (382) 255-50-57

Tursky@cardio-tomsk.ru

Закопайко

Б. А.

Zakopayko

B. A.

Закопайко Богдан Андреевич.

Санкт-Петербург

St. Petersburg

bogdanzakopayko@gmail.com

Кондратьева

Д. С.

Kondratieva

D. S.

Кондратьева Дина Степановна.

Томск

Tomsk

dina@cardio-tomsk.ru

Земляной

Д. А.

Zemlyanoy

D. A.

Земляной Дмитрий Алексеевич.

Санкт-Петербург

St. Petersburg

zemlianoj@mail.ru

Рагузина

Д. В.

Raguzina

D. V.

Рагузина Дарья Вячеславовна.

Санкт-Петербург

St. Petersburg

daryavyacheslavovna@inbox.ru

Попов

С. В.

Popov

S. V.

Попов Сергей Валентинович.

Томск

Tomsk

psv@cardio-tomsk.ru

Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукРоссияTomsk National Research Medical CenterRussian Federation

ФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» Минобороны РоссииРоссияKirov Military Medical AcademyRussian Federation

ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияSt. Petersburg State Pediatric Medical UniversityRussian Federation

2026

28062026

282188201

2026

Афанасьев С.А., Закопайко Б.А., Кондратьева Д.С., Земляной Д.А., Рагузина Д.В., Попов С.В.

Afanasiev S.A., Zakopayko B.A., Kondratieva D.S., Zemlyanoy D.A., Raguzina D.V., Popov S.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/2067

Развитие регенеративной медицины дало основание для оправданного ожидания разработки альтернативных методов лечения сердечной недостаточности и других патологий сердечно-сосудистой системы. Одним из перспективных направлений для этого является создание гелеобразующих материалов на основе децеллюляризированных межклеточных матриксов различных тканей. Сообщения об эффективности использования таких материалов в эксперименте варьируют от высокой до весьма сомнительной. Причиной этого могут являться различия в тканях, используемых для получения матрикса, протоколах и эффективности их децеллюляризации. В настоящем обзоре представлены исследования, характеризующие перспективность применения бесклеточных инъекционных продуктов из биологических аллогенных материалов для стимуляции эндогенных саногенетических механизмов регенерации сердечной мышцы.

Advances in regenerative medicine have generated strong interest in the development of alternative treatments for heart failure and other cardiovascular diseases. Among these, gel-forming materials derived from decellularized extracellular matrices of various tissues have emerged as a promising avenue. However, reported outcomes of their effectiveness remain inconsistent, ranging from high to highly questionable. This may be due to differences in the tissues used to obtain the matrix, decellularization protocols and efficiency. This review summarizes current studies evaluating the potential of acellular injectable products derived from allogeneic biological sources to stimulate endogenous sanogenetic mechanisms in cardiac muscle regeneration.

регенеративная медицинамежклеточный матриксдецеллюляризациятканевая инженерияпуповинарегенерация миокарда

regenerative medicineextracellular matrixdecellularizationtissue engineeringumbilical cordmyocardial regeneration

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The authors declare that there are no conflicts of interest present.