vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2025-4-146-157vtio-2054Research ArticleДонорство органовOrgan DonationТрансплантация почек, полученных от доноров с расширенными критериями. Первое в РФ когортное многоцентровое исследованиеKidney transplantation from expanded criteria donors. The first multicenter cohort study in the Russian FederationБанкеевД. А.BankeevD. A.

Банкеев Дмитрий Александрович

125284, Москва, 2-й Боткинский проезд, 5, корп. 17

Moscow

79127430997@ya.ruЗулькарнаевА. Б.ZulkarnaevA. B.

Алексей Батыргараевич Зулькарнаев 

Москва

Moscow

МининаМ. Г.MininaM. G.

Марина Геннадьевна Минина

Москва

 

Moscow

minmar50@yahoo.comБогдановВ. С.BogdanovV. S.

Василий Сергеевич Богданов 

Москва

Moscow

ТенчуринаЭ. А.TenchurinaE. A.

Эльвира Анвяровна Тенчурина 

Москва

Moscow

СевостьяновВ. М.SevostyanovV. M.

Москва

Moscow

ГБУЗ «Московский многопрофильный научно-клинический центр имени С.П. Боткина Департамента здравоохранения города Москвы»РоссияBotkin HospitalRussian FederationГБУЗ «Московский многопрофильный научно-клинический центр имени С.П. Боткина Департамента здравоохранения города Москвы»РоссияBotkin Hospital; Shumakov National Medical Research Center of Transplantology and Artificial OrgansRussian Federation202510012026274146157Copyright © Банкеев Д.А., Зулькарнаев А.Б., Минина М.Г., Богданов В.С., Тенчурина Э.А., Севостьянов В.М., 20262026Банкеев Д.А., Зулькарнаев А.Б., Минина М.Г., Богданов В.С., Тенчурина Э.А., Севостьянов В.М.Bankeev D.A., Zulkarnaev A.B., Minina M.G., Bogdanov V.S., Tenchurina E.A., Sevostyanov V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/2054

Использование доноров с расширенными критериями является эффективным способом увеличения количества трансплантаций. При этом в России отсутствуют крупные исследования по оценке результатов трансплантации почки от доноров с расширенными критериями. В Москве в условиях эффективного функционирования оригинальной модели донорства органов для трансплантации накоплен значительный опыт работы с донорами, соответствующими расширенным критериям донорства почек по UNOS. В настоящей публикации представлены эпидемиологические характеристики доноров и реципиентов, включенных в исследование, и среднесрочные результатам трансплантаций почек от доноров с расширенными критериями. Исследование является первым в РФ когортным многоцентровым исследованием, посвященным трансплантации почек от доноров с расширенными критериями. Основой базы данных стала систематизированная информация о донорах Московского городского координационного центра органного донорства ММНКЦ им. С.П. Боткина ДЗМ (МГКЦОД) за 2021-2022 гг. С 2021 по 2022 гг. в 21 стационаре города Москвы выполнены эксплантации у 254 доноров, соответствующих расширенным критериям UNOS. Время наблюдения за реципиентами после трансплантации было ограничено четырьмя годами.Выживаемость реципиентов составила 0,882 [95% ДИ 0,839; 0,927] через 4 года после трансплантации, трансплантата – 0,806 [95% ДИ 0,739; 0,880] (утрата по любой причине), 0,887 [95%ДИ 0,825; 0,952] (смерть-цензурированная выживаемость) соответственно. У реципиентов, получивших почки от доноров с расширенными критериями, отмечалась первичная функция трансплантата в 61,4%. Среднесрочная выживаемость реципиентов и трансплантатов является приемлемой и сопоставимой с аналогичными зарубежными исследованиями, что указывает на безопасность и эффективность увеличения количества трансплантаций почки посредством расширения критериев доноров. 

The use of expanded criteria donors (ECDs) is an effective strategy to increase the availability of organs for transplantation. However, in Russia, there have been no large-scale studies evaluating the outcomes of kidney transplantation (KT) from ECDs. In Moscow, through successful implementation of an original organ donation model, considerable experience has been accumulated in managing donors who meet the UNOS expanded criteria for kidney donation. This paper presents the epidemiological characteristics of donors and recipients, as well as the medium-term outcomes of KT from ECDs. The study represents the first multicenter cohort study in the Russian Federation dedicated to kidney transplants from ECDs. The database was developed using systematized donor information from the Moscow Coordination Center for Organ Donation at Botkin Hospital for the period 2021–2022. During this time, 254 donors meeting UNOS expanded criteria underwent organ explantation at 21 hospitals in Moscow. The follow-up period for KT recipients was limited to four years. Recipient survival at 4 years after transplantation was 0.882 [95% CI 0.839–0.927], while overall graft survival (loss from any cause) was 0.806 [95% CI 0.739–0.880] and death-censored graft survival was 0.887 [95% CI 0.825–0.952]. Primary graft function was observed in 61.4% of recipients who received kidneys from ECDs. The medium-term survival rates of both recipients and grafts are acceptable and comparable to those reported in international studies, confirming the safety and effectiveness of expanding donor criteria to increase the number of kidney transplants.

 

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The authors declare that there are no conflicts of interest present.