vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2026-1-263-275vtio-1999Research ArticleИмплантаты и искусственные органыImplants and Artificial OrgansHydroxyapatite as a material for transplantology: clinical experience and prospects of applicationHydroxyapatite as a material for transplantology: clinical experience and prospects of applicationhttps://orcid.org/0000-0002-0663-7219MarkelovV. A.MarkelovV. A.

Vitaliy Markelov

3, Lenin str., Ufa, 450008

Phone: (987) 097-92-48

Vitaliy Markelov

Lenin str., Ufa, 450008

Phone: (987) 097-92-48

vamarkelov@bashgmu.ruhttps://orcid.org/0000-0002-4374-2923DanilkoK. V.DanilkoK. V.

Ufa

Ufa

kse-danilko@yandex.ruhttps://orcid.org/0009-0001-0942-0250YazgarovaR. R.YazgarovaR. R.

Ufa

Ufa

rozaliuyazgarova@gmail.comhttps://orcid.org/0000-0003-4772-2302AkhatovI. Sh.AkhatovI. Sh.

Ufa

Ufa

iakhatov@bashgmu.ruPavlovV. N.PavlovV. N.

Ufa

Ufa

pavlov@bashgmu.ruBashkir State Medical UniversityРоссияBashkir State Medical UniversityRussian Federation202631032026281263275Copyright © Markelov V.A., Danilko K.V., Yazgarova R.R., Akhatov I.S., Pavlov V.N., 20262026Markelov V.A., Danilko K.V., Yazgarova R.R., Akhatov I.S., Pavlov V.N.Markelov V.A., Danilko K.V., Yazgarova R.R., Akhatov I.S., Pavlov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1999

The centrepiece of this analytical review is the metabolism of hydroxyapatite in its natural, bone, and synthetic forms, where the mitochondria-mediated mechanism may serve as the leading mechanism. The possibility that osteoblast mitochondria play an important role in the initial stages of bone mineralisation is discussed. Furthermore, the paper highlights the key role of mitochondria in the metabolism of synthetic hydroxyapatite. Differences between the results of in vivo and in vitro studies using synthetic hydroxyapatite of different morphologies are also detailed. It is noted that long-term infiltration with immune cells and in vivo studies are necessary to adequately evaluate hydroxyapatite as a bone-plastic material. Particular attention is given to the interaction of hydroxyapatite with immune cells and its ability to affect the ribosomes and mitochondria of cells. Due to its mechanical properties, scalability, and potential use for the treatment of extensive bone defects of tumor origin, hydroxyapatite is a promising material. This study also highlights the importance of further development of in vitro research methods in the context of their biomimeticity. Overall, this work offers a theoretical direction for future studies of hydroxyapatite as a bone grafting material and emphasises the value of in vivo studies.

The centrepiece of this analytical review is the metabolism of hydroxyapatite in its natural, bone, and synthetic forms, where the mitochondria-mediated mechanism may serve as the leading mechanism. The possibility that osteoblast mitochondria play an important role in the initial stages of bone mineralisation is discussed. Furthermore, the paper highlights the key role of mitochondria in the metabolism of synthetic hydroxyapatite. Differences between the results of in vivo and in vitro studies using synthetic hydroxyapatite of different morphologies are also detailed. It is noted that long-term infiltration with immune cells and in vivo studies are necessary to adequately evaluate hydroxyapatite as a bone-plastic material. Particular attention is given to the interaction of hydroxyapatite with immune cells and its ability to affect the ribosomes and mitochondria of cells. Due to its mechanical properties, scalability, and potential use for the treatment of extensive bone defects of tumor origin, hydroxyapatite is a promising material. This study also highlights the importance of further development of in vitro research methods in the context of their biomimeticity. Overall, this work offers a theoretical direction for future studies of hydroxyapatite as a bone grafting material and emphasises the value of in vivo studies.

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The authors declare that there are no conflicts of interest present.