vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2025-4-125-132vtio-1985Research ArticleРегенеративная медицина и клеточные технологииRegenerative Medicine and Cell TechnologiesИсследование механических и структурных свойств шелковых скаффолдов для тканевой инженерии и реконструктивной хирургииSilk-based scaffolds for tissue engineering and reconstructive surgery: mechanical and structural propertiesПодболотоваЕ. И.PodbolotovaE. I.

Екатерина Игоревна Подболотова 

Москва

Moscow; Dolgoprudny

podbolotova.ei@phystech.eduПашутинА. Р.PashutinA. R.

Александр Романович Пашутин 

Москва

Moscow; Dolgoprudny

pashutin.ar@phystech.eduГрудининН. В.GrudininN. V.

Никита Владимирович Грудинин 

Москва

Moscow

zbignev.religa@mail.ruВолковаЕ. А.AgapovI. I.

Москва

Moscow

igor_agapov@mail.ruАгаповаО. И.VolkovaE. A.

Ольга Игоревна Агапова 

Москва

Moscow

ЕфимовА. Е.AgapovaO. I.

Антон Евгеньевич Ефимов

Москва

Moscow

АгаповИ. И.EfimovA. E.

Игорь Иванович Агапов 

123182, Москва, ул. Щукинская, д. 1

Moscow

igor_agapov@mail.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Московский физико-технический институт (Национальный исследовательский университет)»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Moscow Institute of Physics and TechnologyRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Московский физико-технический институт (Национальный исследовательский университет)»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Moscow Institute of Physics and TechnologyRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian Federation202510012026274125132Copyright © Подболотова Е.И., Пашутин А.Р., Грудинин Н.В., Волкова Е.А., Агапова О.И., Ефимов А.Е., Агапов И.И., 20262026Подболотова Е.И., Пашутин А.Р., Грудинин Н.В., Волкова Е.А., Агапова О.И., Ефимов А.Е., Агапов И.И.Podbolotova E.I., Pashutin A.R., Grudinin N.V., Agapov I.I., Volkova E.A., Agapova O.I., Efimov A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1985

Шёлк является перспективным природным биоматериалом, обладающим уникальным сочетанием механической прочности, биосовместимости и управляемой деградации, что делает его особенно привлекательным для создания скаффолдов для клинической практики. В данной работе исследовано влияние степени обработки шелковых тканей на морфологические и механические характеристики полученных скаффолдов. Установлено, что изменение режимов обработки позволяет получать материалы с заданными свойствами — от плотных и прочных до пористых и быстро биодеградирующих структур. Образцы с высокой плотностью («Фиброплен-Атлас») демонстрировали значительную механическую устойчивость и перспективны для применения в хирургии зон с высокой нагрузкой (связки, фасции, сухожилия). Более рыхлые и пористые скаффолды («Фиброплен-Газ») характеризовались ускоренной деградацией и подходят для задач регенерации мягких тканей. Таким образом, полученные материалы демонстрируют потенциал для персонализированного подбора скаффолдов в зависимости от клинических задач, требующих определённого баланса между механической стабильностью и скоростью биодеструкции.

Silk is a promising natural biomaterial that combines mechanical strength, biocompatibility, and controlled biodegradation, making it highly suitable for scaffold creation for clinical practice. This study investigates how different processing methods influence the morphological and mechanical characteristics of silk-based scaffolds. The fi ndings showed that varying the processing conditions facilitates the production of materials with tailored properties, ranging from dense, mechanically robust structures to porous, rapidly degradable scaffolds. Highdensity samples (Fibroplen-Atlas) exhibited substantial mechanical stability, making them promising candidates for surgical applications in mechanically demanding areas such as ligaments, fascia, and tendons. In contrast, more porous scaffolds (Fibroplen-Gas) demonstrated accelerated biodegradation, which is advantageous for soft tissue regeneration. These results highlight the potential of silk scaffolds for personalized applications, where the balance between mechanical stability and biodegradation rate can be adjusted according to specific clinical needs.

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The authors declare that there are no conflicts of interest present.