vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2025-3-146-159vtio-1970Research ArticleРЕГЕНЕРАТИВНАЯ МЕДИЦИНА И КЛЕТОЧНЫЕ ТЕХНОЛОГИИREGENERATIVE MEDICINE AND CELL TECHNOLOGIESБиомиметики внеклеточного матрикса для тканевой инженерии поджелудочной железыExtracellular matrix biomimetics for pancreatic tissue engineeringПономареваА. С.PonomarevaA. S.

Пономарева Анна Сергеевна.

123182, Москва, ул. Щукинская, д. 1

Тел.: (499) 196-26-61; (926) 585-23-73

Anna S. Ponomareva.

1, Shchukinskaya str., Moscow, 123182

Phone: (499) 196-26-61; (926) 585-23-73

a.s.ponomareva@gmail.comБарановаН. В.BaranovaN. V.

Баранова Наталья Владимировна.

Москва

Moscow

barnats@yandex.ruБасокЮ. Б.BasokYu. B.

Басок Юлия Борисовна.

Москва

Moscow

bjb2005@mail.ruСевастьяновВ. И.SevastianovV. I.

Севастьянов Виктор Иванович.

Москва

Moscow

viksev@yandex.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; АНО «Институт медико-биологических исследований и технологий»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Institute of Biomedical Research and TechnologyRussian Federation202503092025273146159Copyright © Пономарева А.С., Баранова Н.В., Басок Ю.Б., Севастьянов В.И., 20252025Пономарева А.С., Баранова Н.В., Басок Ю.Б., Севастьянов В.И.Ponomareva A.S., Baranova N.V., Basok Y.B., Sevastianov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1970

Трансплантация изолированных островков Лангерганса применяется как более безопасная и менее инвазивная процедура, альтернативная пересадке поджелудочной железы для пациентов с осложненным течением сахарного диабета I типа. Однако потеря васкуляризации, иннервации, связи с внеклеточным матриксом (ВКМ), а также развивающаяся гипоксия, окислительный стресс, воспалительные реакции, токсическое действие иммуносупрессоров значительно снижают жизнеспособность островков и ограничивают функцию трансплантата. Подходы тканевой инженерии и регенеративной медицины направлены на преодоление этих проблем. Разработка способов получения биосовместимых скаффолдов-биомиметиков ВКМ (каркасов, носителей, матриксов), способных обеспечить механическую поддержку и адекватное микроокружение островковым клеткам in vitro и in vivo, – одна из ключевых задач тканевой инженерии. Цель обзора – систематизация данных о применении биомиметиков ВКМ для создания устойчиво функционирующей тканеинженерной конструкции поджелудочной железы.

Isolated islet transplantation offers a safer and less invasive alternative to whole pancreas transplantation for patients with complicated type 1 diabetes mellitus. However, the procedure faces significant challenges, including the loss of vascularization, innervation, and extracellular matrix (ECM) support. Additionally, factors such as hypoxia, oxidative stress, inflammatory responses, and the cytotoxic effects of immunosuppressive therapy compromise islet viability significantly and limit long-term graft function. Tissue engineering and regenerative medicine strategies aim to address these challenges. A central objective is the development of biocompatible, biomimetic ECM scaffolds (frameworks, carriers, or matrices) that can provide both mechanical support and a suitable microenvironment for islet cells in vitro and in vivo. This review aims to systematize current data on the use of biomimetic ECMs in the creation of stable, tissue-engineered pancreatic constructs.

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The authors declare that there are no conflicts of interest present.