vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2025-2-127-138vtio-1882Research ArticleРегенеративная медицина и клеточные технологииRegenerative Medicine and Cell TechnologiesОсобенности преклинических испытаний тканеинженерных сосудистых протезов с биодеградируемой составляющей: результативность различных животных моделей – от крыс до приматов (проблемная статья)Preclinical evaluation of tissue-engineered vascular grafts with biodegradable components: assessing the effectiveness of animal models from rats to primatesАнтоноваЛ. В.AntonovaL. V.

Антонова Лариса Валерьевна, ведущий научный сотрудник лаборатории технологий, д.м.н.

650002, Кемерово, б-р Акад. Л.С. Барбараша, 6

Тел. (926) 857-38-69

 

Larisa Antonova

6, Bul’var im. Akademika L.S. Barbarasha, Kemerovo, 650002

Phone: (999) 648-50-41

antonova.la@mail.ruhttps://orcid.org/0000-0002-9430-937XСенокосоваЕ. А.SenokosovaE. A.

Сенокосова Евгения Андреевна, заведующий лабораторией клеточных технологий, к.б.н.

Кемерово

Kemerovo

sergeewa.ew@yandex.ruhttps://orcid.org/0000-0002-8846-5077МироновА. В.MironovA. V.

Миронов Андрей Владимирович, младший научный сотрудник лаборатории клеточных технологий, к.м.н.

Кемерово

Kemerovo

a.mir.80@mail.ruhttps://orcid.org/0000-0002-9734-8462ШабаевА. Р.ShabaevA. R.

Шабаев Амин Рашитович, младший научный сотрудник лаборатории клеточных технологий

Кемерово

Kemerovo

shabar@kemcardio.ruhttps://orcid.org/0000-0003-4572-6385СардинЕ. С.SardinE. S.

Сардин Егор Сергеевич, младший научный сотрудник лаборатории анестезиологии и реаниматологии

Кемерово

Kemerovo

sardines@mail.ruhttps://orcid.org/0000-0002-4146-3373МатвееваВ. Г.MatveevaV. G.

Матвеева Вера Геннадьевна, старший научный сотрудник лаборатории клеточных технологий, к.м.н.

Кемерово

Kemerovo

matveeva_vg@mail.ruhttps://orcid.org/0000-0002-2500-2147КривкинаЕ. О.KrivkinaE. O.

Кривкина Евгения Олеговна, младший научный сотрудник лаборатории клеточных технологий

Кемерово

Kemerovo

krivkina.evgeniya@gmail.comhttps://orcid.org/0000-0002-8826-9244ХановаМ. Ю.KhanovaM. Yu.

Ханова Марьям Юрисовна, научный сотрудник лаборатории клеточных технологий, к.б.н.

Кемерово

Kemerovo

khanovam@gmail.comТоргунаковаЕ. А.TorgunakovaE. A.

Торгунакова Евгения Александровна, младший научный сотрудник лаборатории клеточных технологий

Кемерово

Kemerovo

evgeniyatorgunakova@mail.ruБарбарашЛ. С.BarbarashL. S.

Барбараш Леонид Семенович, главный научный сотрудник, академик РАН

Кемерово

Kemerovo

reception@kemcardio.ruФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation202512072025272127138Copyright © Антонова Л.В., Сенокосова Е.А., Миронов А.В., Шабаев А.Р., Сардин Е.С., Матвеева В.Г., Кривкина Е.О., Ханова М.Ю., Торгунакова Е.А., Барбараш Л.С., 20252025Антонова Л.В., Сенокосова Е.А., Миронов А.В., Шабаев А.Р., Сардин Е.С., Матвеева В.Г., Кривкина Е.О., Ханова М.Ю., Торгунакова Е.А., Барбараш Л.С.Antonova L.V., Senokosova E.A., Mironov A.V., Shabaev A.R., Sardin E.S., Matveeva V.G., Krivkina E.O., Khanova M.Y., Torgunakova E.A., Barbarash L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1882

На рынке изделий для нужд сердечно-сосудистой хирургии до сих пор не существует эффективного сосу- дистого протеза диаметром менее 4 мм. Альтернативой сосудистого аналога артерий может стать ткане- инженерный функционально активный сосудистый протез, обладающий пролонгированной резорбцией и способностью к регенерации, что позволило бы исключить повторные операции по замене несостоятель- ных сосудистых протезов. Полнота определения рисков несостоятельности биодеградируемых протезов сосудов малого диаметра, подвергаемых преклиническим испытаниям, напрямую зависит от животной модели, выбранной для проведения подобных испытаний. В данной проблемной статье представлены итоги полного цикла преклинических испытаний разработанного в НИИ КПССЗ сосудистого протеза малого диаметра и сделаны выводы об эффективности и целесообразности использования различных животных моделей при тестировании протезов сосудов малого диаметра с биодеградируемой составляющей.

Currently, there are no highly effective small-diameter (≤4 mm) grafts on the market for cardiovascular surgery. Tissue-engineered, functionally active vascular grafts with prolonged resorption and regeneration capacity have the potential to serve as alternatives to traditional arterial grafts. These bioengineered grafts could eliminate the need for repeated surgical interventions to replace failed grafts. The accuracy of assessing the risks of failure in biodegradable small-diameter vascular grafts (SDVGs) during preclinical trials is highly dependent on the choice of animal model. This article presents the results of comprehensive preclinical trials conducted on an SDVG developed at the Research Institute for Complex Issues of Cardiovascular Diseases. Based on these findings, the study evaluates the effectiveness and feasibility of different animal models for testing biodegradable SDVGs.

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The authors declare that there are no conflicts of interest present.