vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2025-1-114-134vtio-1874Research ArticleРегенеративная медицина и клеточные технологииRegenerative Medicine and Cell TechnologiesПрименение мезенхимальных стромальных клеток при трансплантации солидных органов: вызовы и перспективы (систематический обзор)Use of mesenchymal stem cells in solid organ transplantation: challenges and prospects (systematic review)https://orcid.org/0000-0003-4807-3164БасокЮ. Б.BasokYu. B.

Басок Юлия Борисовна

123182, Москва, ул. Щукинская, д. 1. Тел. (499) 190-45-90

Yulia Basok

1, Shchukinskaya str., Moscow, 123182  Phone: (499) 190-45-90 

bjb2005@mail.ruhttps://orcid.org/0000-0002-5065-9458ПономареваА. С.PonomarevaA. S.

Москва

Moscow 

a.s.ponomareva@gmail.comГрудининН. В.GrudininN. V.

Москва

Moscow 

nikita.grudinin@mail.ruКругловД. Н.KruglovD. N.

Москва

Moscow 

taman@list.ruБогдановВ. К.BogdanovV. K.

Москва

Moscow 

a.s.ponomareva@gmail.comhttps://orcid.org/0000-0003-2938-5883БеловаА. Д.BelovaA. D.

Москва

Moscow 

sashak1994@mail.ruhttps://orcid.org/0000-0003-1995-3373СевастьяновВ. И.SevastianovV. I.

Москва

Moscow 

viksev@yandex.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В. И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России ; АНО «Институт медико-биологических исследований и технологий»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs ; Institute of Biomedical Research and TechnologyRussian Federation202526032025271114134Copyright © Басок Ю.Б., Пономарева А.С., Грудинин Н.В., Круглов Д.Н., Богданов В.К., Белова А.Д., Севастьянов В.И., 20252025Басок Ю.Б., Пономарева А.С., Грудинин Н.В., Круглов Д.Н., Богданов В.К., Белова А.Д., Севастьянов В.И.Basok Y.B., Ponomareva A.S., Grudinin N.V., Kruglov D.N., Bogdanov V.K., Belova A.D., Sevastianov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1874

Трансплантация донорских органов продолжает оставаться «золотым стандартом» при спасении жизни пациентов с терминальной стадией органного поражения и направлена на продление и улучшение качества жизни реципиентов. Однако, несмотря на прогрессивное развитие, трансплантация органов по-прежнему сталкивается с серьезными вызовами, такими как дефицит донорских органов и последствия длительной иммуносупрессии. В связи с этим активно ведется поиск терапевтических подходов, способных повысить эффективность аллогенной трансплантации органов. Мезенхимальные стромальные клетки (МСК) способны существенно усиливать и ускорять восстановительные процессы в поврежденных органах, могут стимулировать ангиогенез и предотвращать апоптоз клеток, воспаление и формирование фиброза, обладают иммуномодулирующими свойствами. МСК привлекают внимание исследователей и врачей благодаря набору уникальных свойств, которые могут быть полезны при трансплантации солидных органов. В обзоре дан критический анализ и обобщены фактические клинические данные, касающиеся исследования терапевтического эффекта МСК при трансплантации органов. Поиск литературы проводился в электронных базах данных Medline/PubMed (www/ncbi.nlm.nih.gov/pubmed) и eLIBRARY/Российский индекс научного цитирования (https://www.elibrary.ru). Критерием включения было клиническое использование МСК для улучшения состояния реципиентов почки, печени, легких, сердца и поджелудочной железы и повышения качества трансплантатов. Критериями исключения статей были применение МСК для лечения больных, которым не проводили трансплантацию, а также статьи, описывающие действие продуктов МСК (экзосомы, везикулы и кондиционированные среды), и научные работы, выполненные в условиях in vitro и in vivo (без участия пациентов), а также материалы конференций, обзоры и препринты статей. Для анализа литературы была выбрана 31 оригинальная статья на английском и русском языках. Также в обзоре обсуждаются перспективы применения МСК в трансплантологии.

Organ transplantation continues to be the gold standard for saving the lives of patients with end-stage organ diseases. Its goal is to help recipients live longer and better lives. However, despite advancements, organ transplantation still faces serious challenges, such as organ shortage and the effects of chronic immunosuppression. In this regard, there is ongoing vigorous search for therapeutic strategies that can improve the efficacy of allogeneic organ transplantation. Mesenchymal stems cells (MSCs) can significantly enhance and accelerate regenerative processes in damaged organs, can angiogenesis angiogenesis and inhibit cell apoptosis, inflammation and fibrosis formation, and have immunomodulatory properties. Researchers and physicians are interested in MSCs because of a set of unique properties that could be useful in solid organ transplantation. This review critically analyzes and summarizes the actual clinical data related to the study of the therapeutic effects of MSCs in organ transplantation. Electronic databases Medline/PubMed (www/ncbi.nlm.nih.gov/pubmed) and eLIBRARY/Russian Science Citation Index (https://www.elibrary.ru) were searched for relevant literature. Inclusion criteria were clinical use of MSCs to improve the condition of kidney, liver, lung, heart and pancreas recipients, and to enhance graft quality. Exclusion criteria for articles included the use of MSCs for the treatment of non-transplant patients, as well as articles detailing the effects of MSCs products (exosomes, vesicles and conditioned media) and research studies conducted in vitro and in vivo (without patient participation), conference proceedings, reviews and preprints of articles. Thirty-one original articles in English and Russian languages were selected for literature review. The prospects of MSCs in transplantology are also covered in the paper.

мезенхимальные стромальные клеткитрансплантация почкитрансплантация печенитрансплантация легкихex vivo перфузиярегенеративная медицинаmesenchymal stem cellskidney transplantationliver transplantationlung transplantationex vivo perfusionregenerative medicineReferencesГотье СВ, Хомяков СМ. Донорство и трансплантация органов в Российской Федерации в 2022 году. XV сообщение регистра Российского трансплантологического общества. Вестник трансплантологии и искусственных органов. 2023; 25 (3): 8–30. doi: 10.15825/1995-1191-2023-3-8-30.Gautier SV, Khomyakov SM. Organ donation and transplantation in the Russian Federation in 2022. 15th Report from the Registry of the Russian Transplant Society. Russian Journal of Transplantology and Artificial Organs. 2023; 25 (3): 8–30. [In Russ, English abstract]. doi: 10.15825/1995-1191-2023-3-8-30.Готье СВ, Хомяков СМ. Оценка потребности населения в трансплантации органов, донорского ресурса и планирование эффективной сети медицинских организаций (центров трансплантации). Вестник трансплантологии и искусственных органов. 2013; 15 (3): 11–24. doi: 10.15825/1995-1191-2013-3-11-24.Gautier SV, Khomyakov SM. Assessment of requirement of the population in the organ transplantation, the donor resource and planning of the effective network of the medical organizations (the centers of transplantation). Russian Journal of Transplantology and Artificial Organs. 2013; 15 (3): 11–24. [In Russ, English abstract]. doi: 10.15825/1995-1191-2013-3-11-24.Lewis A, Koukoura A, Tsianos GI, Gargavanis AA, Nielsen AA, Vassiliadis E. Organ donation in the US and Europe: The supply vs demand imbalance. Transplant Rev (Orlando). 2021; 35 (2): 100585. doi: 10.1016/j.trre.2020.100585. PMID: 33071161.Lewis A, Koukoura A, Tsianos GI, Gargavanis AA, Nielsen AA, Vassiliadis E. Organ donation in the US and Europe: The supply vs demand imbalance. Transplant Rev (Orlando). 2021; 35 (2): 100585. doi: 10.1016/j.trre.2020.100585. PMID: 33071161.Галеев ШР, Готье СВ. Риски и пути профилактики нарушения функции почек при проведении медикаментозной иммуносупрессии у реципиентов солидных органов. Вестник трансплантологии и искусственных органов. 2022; 24 (4): 24–38. doi: 10.15825/1995-1191-2022-4-24-38.Galeev ShR, Gautier SV. Risks and ways of preventing kidney dysfunction in drug-induced immunosuppression in solid organ recipients. Russian Journal of Transplantology and Artificial Organs. 2022; 24 (4): 24–38. [In Russ, English abstract]. doi: 10.15825/1995-1191-2022-4-24-38.Parlakpinar H, Gunata M. Transplantation and immunosuppression: a review of novel transplantrelated immunosuppressant drugs. Immunopharmacol Immunotoxicol. 2021; 43 (6): 651–665. doi: 10.1080/08923973.2021.1966033. PMID: 34415233.Parlakpinar H, Gunata M. Transplantation and immunosuppression: a review of novel transplantrelated immunosuppressant drugs. Immunopharmacol Immunotoxicol. 2021; 43 (6): 651–665. doi: 10.1080/08923973.2021.1966033. PMID: 34415233.Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8 (4): 315–317. doi: 10.1080/14653240600855905. PMID: 16923606.Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8 (4): 315–317. doi: 10.1080/14653240600855905. PMID: 16923606.Wu X, Jiang J, Gu Z, Zhang J, Chen Y, Liu X. Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress. Stem Cell Res Ther. 2020; 11 (1): 345. doi: 10.1186/s13287-020-01855-9. PMID: 32771052.Wu X, Jiang J, Gu Z, Zhang J, Chen Y, Liu X. Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress. Stem Cell Res Ther. 2020; 11 (1): 345. doi: 10.1186/s13287-020-01855-9. PMID: 32771052.Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019; 4: 22. doi: 10.1038/s41536-019-0083-6. PMID: 31815001.Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019; 4: 22. doi: 10.1038/s41536-019-0083-6. PMID: 31815001.Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J et al. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Target Ther. 2022; 7 (1): 92. doi: 10.1038/s41392-022-00932-0. PMID: 35314676.Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J et al. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Target Ther. 2022; 7 (1): 92. doi: 10.1038/s41392-022-00932-0. PMID: 35314676.Guo Y, Yu Y, Hu S, Chen Y, Shen Z. The therapeutic potential of mesenchymal stem cells for cardiovascular diseases. Cell Death Dis. 2020; 11 (5): 349. doi: 10.1038/s41419-020-2542-9. PMID: 32393744.Guo Y, Yu Y, Hu S, Chen Y, Shen Z. The therapeutic potential of mesenchymal stem cells for cardiovascular diseases. Cell Death Dis. 2020; 11 (5): 349. doi: 10.1038/s41419-020-2542-9. PMID: 32393744.Poomani MS, Mariappan I, Perumal R, Regurajan R, Muthan K, Subramanian V. Mesenchymal stem cell (MSCs) therapy for ischemic heart disease: a promising frontier. Glob Heart. 2022; 17 (1): 19. doi: 10.5334/gh.1098. PMID: 35342702.Poomani MS, Mariappan I, Perumal R, Regurajan R, Muthan K, Subramanian V. Mesenchymal stem cell (MSCs) therapy for ischemic heart disease: a promising frontier. Glob Heart. 2022; 17 (1): 19. doi: 10.5334/gh.1098. PMID: 35342702.Li K, Li X, Shi G, Lei X, Huang Y, Bai L et al. Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson’s disease: a systematic review and meta-analysis. Transl Neurodegener. 2021; 10: 14. doi: 10.1186/s40035-021-00238-1. PMID: 33926570.Li K, Li X, Shi G, Lei X, Huang Y, Bai L et al. Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson’s disease: a systematic review and meta-analysis. Transl Neurodegener. 2021; 10: 14. doi: 10.1186/s40035-021-00238-1. PMID: 33926570.Carstens M, Haq I, Martinez-Cerrato J, Dos-Anjos S, Bertram K, Correa D. Sustained clinical improvement of Parkinson’s disease in two patients with faciallytransplanted adipose-derived stromal vascular fraction cells. J Clin Neurosci. 2020; 81: 47–51. doi: 10.1016/j.jocn.2020.09.001. PMID: 33222965.Carstens M, Haq I, Martinez-Cerrato J, Dos-Anjos S, Bertram K, Correa D. Sustained clinical improvement of Parkinson’s disease in two patients with faciallytransplanted adipose-derived stromal vascular fraction cells. J Clin Neurosci. 2020; 81: 47–51. doi: 10.1016/j.jocn.2020.09.001. PMID: 33222965.Zaripova LN, Midgley A, Christmas SE, Beresford MW, Pain C, Baildam EM et al. Mesenchymal stem cells in the pathogenesis and therapy of autoimmune and autoinflammatory diseases. Int J Mol Sci. 2023; 24 (22): 16040. doi: 10.3390/ijms242216040. PMID: 38003230.Zaripova LN, Midgley A, Christmas SE, Beresford MW, Pain C, Baildam EM et al. Mesenchymal stem cells in the pathogenesis and therapy of autoimmune and autoinflammatory diseases. Int J Mol Sci. 2023; 24 (22): 16040. doi: 10.3390/ijms242216040. PMID: 38003230.Jasim SA, Yumashev AV, Abdelbasset WK, Margiana R, Markov A, Suksatan W et al. Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases. Stem Cell Res Ther. 2022; 13 (1): 101. doi: 10.1186/s13287-022-02782-7. PMID: 35255979.Jasim SA, Yumashev AV, Abdelbasset WK, Margiana R, Markov A, Suksatan W et al. Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases. Stem Cell Res Ther. 2022; 13 (1): 101. doi: 10.1186/s13287-022-02782-7. PMID: 35255979.Cruz FF, Rocco PRM. The potential of mesenchymal stem cell therapy for chronic lung disease. Expert Rev Respir Med. 2020; 14 (1): 31–39. doi: 10.1080/17476348.2020.1679628. PMID: 31608724.Cruz FF, Rocco PRM. The potential of mesenchymal stem cell therapy for chronic lung disease. Expert Rev Respir Med. 2020; 14 (1): 31–39. doi: 10.1080/17476348.2020.1679628. PMID: 31608724.Han HT, Jin WL, Li X. Mesenchymal stem cells-based therapy in liver diseases. Mol Biomed. 2022; 3 (1): 23. doi: 10.1186/s43556-022-00088-x. PMID: 35895169.Han HT, Jin WL, Li X. Mesenchymal stem cells-based therapy in liver diseases. Mol Biomed. 2022; 3 (1): 23. doi: 10.1186/s43556-022-00088-x. PMID: 35895169.Chen F, Chen N, Xia C, Wang H, Shao L, Zhou C et al. Mesenchymal stem cell therapy in kidney diseases: potential and challenges. Cell Transplant. 2023; 32: 9636897231164251. doi: 10.1177/09636897231164251. PMID: 37013255.Chen F, Chen N, Xia C, Wang H, Shao L, Zhou C et al. Mesenchymal stem cell therapy in kidney diseases: potential and challenges. Cell Transplant. 2023; 32: 9636897231164251. doi: 10.1177/09636897231164251. PMID: 37013255.Deng Z, Luo F, Lin Y, Luo J, Ke D, Song C et al. Research trends of mesenchymal stem cells application in orthopedics: a bibliometric analysis of the past 2 decades. Front Public Health. 2022; 10: 1021818. doi: 10.3389/fpubh.2022.1021818. PMID: 36225768.Deng Z, Luo F, Lin Y, Luo J, Ke D, Song C et al. Research trends of mesenchymal stem cells application in orthopedics: a bibliometric analysis of the past 2 decades. Front Public Health. 2022; 10: 1021818. doi: 10.3389/fpubh.2022.1021818. PMID: 36225768.Guo BC, Wu KH, Chen CY, Lin WY, Chang YJ, Lee TA et al. Mesenchymal stem cells in the treatment of COVID-19. Int J Mol Sci. 2023; 24 (19): 14800. doi: 10.3390/ijms241914800. PMID: 37834246.Guo BC, Wu KH, Chen CY, Lin WY, Chang YJ, Lee TA et al. Mesenchymal stem cells in the treatment of COVID-19. Int J Mol Sci. 2023; 24 (19): 14800. doi: 10.3390/ijms241914800. PMID: 37834246.Li J, Peng Q, Yang R, Li K, Zhu P, Zhu Y et al. Application of mesenchymal stem cells during machine perfusion: an emerging novel strategy for organ preservation. Front Immunol. 2021; 12: 713920. doi: 10.3389/fimmu.2021.713920. PMID: 35024039.Li J, Peng Q, Yang R, Li K, Zhu P, Zhu Y et al. Application of mesenchymal stem cells during machine perfusion: an emerging novel strategy for organ preservation. Front Immunol. 2021; 12: 713920. doi: 10.3389/fimmu.2021.713920. PMID: 35024039.Deo D, Marchioni M, Rao P. Mesenchymal stem/stromal cells in organ transplantation. Pharmaceutics. 2022; 14 (4): 791. doi: 10.3390/pharmaceutics14040791. PMID: 35456625.Deo D, Marchioni M, Rao P. Mesenchymal stem/stromal cells in organ transplantation. Pharmaceutics. 2022; 14 (4): 791. doi: 10.3390/pharmaceutics14040791. PMID: 35456625.Bezstarosti S, Meziyerh S, Reinders MEJ, Voogt-Bakker K, Groeneweg KE, Roelen DL et al. HLA-DQ eplet mismatch load may identify kidney transplant patients eligible for tacrolimus withdrawal without donor-specific antibody formation after mesenchymal stromal cell therapy. HLA. 2023; 102 (1): 3–12. doi: 10.1111/tan.15008. PMID: 36841928.Bezstarosti S, Meziyerh S, Reinders MEJ, Voogt-Bakker K, Groeneweg KE, Roelen DL et al. HLA-DQ eplet mismatch load may identify kidney transplant patients eligible for tacrolimus withdrawal without donor-specific antibody formation after mesenchymal stromal cell therapy. HLA. 2023; 102 (1): 3–12. doi: 10.1111/tan.15008. PMID: 36841928.Kaundal U, Ramachandran R, Arora A, Kenwar DB, Sharma RR, Nada R et al. Mesenchymal stromal cells mediate clinically unpromising but favourable immune responses in kidney transplant patients. Stem Cells Int. 2022; 2022: 2154544. doi: 10.1155/2022/2154544. PMID: 35211176.Kaundal U, Ramachandran R, Arora A, Kenwar DB, Sharma RR, Nada R et al. Mesenchymal stromal cells mediate clinically unpromising but favourable immune responses in kidney transplant patients. Stem Cells Int. 2022; 2022: 2154544. doi: 10.1155/2022/2154544. PMID: 35211176.Večerić-Haler Ž, Kojc N, Sever M, Zver S, Švajger U, Poženel P et al. Case report: capillary leak syndrome with kidney transplant failure following autologous mesenchymal stem cell therapy. Front Med (Lausanne). 2021; 8: 708744. doi: 10.3389/fmed.2021.708744. PMID: 34368198.Večerić-Haler Ž, Kojc N, Sever M, Zver S, Švajger U, Poženel P et al. Case report: capillary leak syndrome with kidney transplant failure following autologous mesenchymal stem cell therapy. Front Med (Lausanne). 2021; 8: 708744. doi: 10.3389/fmed.2021.708744. PMID: 34368198.Wei Y, Chen X, Zhang H, Su Q, Peng Y, Fu Q et al. Efficacy and safety of bone marrow-derived mesenchymal stem cells for chronic antibody-mediated rejection after kidney transplantation- a single-arm, two-dosing-regimen, phase I/II study. Front Immunol. 2021; 12: 662441. doi: 10.3389/fimmu.2021.662441. PMID: 34248942.Wei Y, Chen X, Zhang H, Su Q, Peng Y, Fu Q et al. Efficacy and safety of bone marrow-derived mesenchymal stem cells for chronic antibody-mediated rejection after kidney transplantation- a single-arm, two-dosing-regimen, phase I/II study. Front Immunol. 2021; 12: 662441. doi: 10.3389/fimmu.2021.662441. PMID: 34248942.Ban TH, Lee S, Kim HD, Ko EJ, Kim BM, Kim KW et al. Clinical trial of allogeneic mesenchymal stem cell therapy for chronic active antibody-mediated rejection in kidney transplant recipients unresponsive to Rituximab and intravenous immunoglobulin. Stem Cells Int. 2021; 2021: 6672644. doi: 10.1155/2021/6672644. PMID: 33628269.Ban TH, Lee S, Kim HD, Ko EJ, Kim BM, Kim KW et al. Clinical trial of allogeneic mesenchymal stem cell therapy for chronic active antibody-mediated rejection in kidney transplant recipients unresponsive to Rituximab and intravenous immunoglobulin. Stem Cells Int. 2021; 2021: 6672644. doi: 10.1155/2021/6672644. PMID: 33628269.Casiraghi F, Perico N, Gotti E, Todeschini M, Mister M, Cortinovis M et al. Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration. Stem Cells Transl Med. 2020; 9 (4): 427–432. doi: 10.1002/sctm.19-0185. PMID: 31872574.Casiraghi F, Perico N, Gotti E, Todeschini M, Mister M, Cortinovis M et al. Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration. Stem Cells Transl Med. 2020; 9 (4): 427–432. doi: 10.1002/sctm.19-0185. PMID: 31872574.Erpicum P, Weekers L, Detry O, Bonvoisin C, Delbouille MH, Grégoire C et al. Infusion of third-party mesenchymal stromal cells after kidney transplantation: a phase I–II, open-label, clinical study. Kidney Int. 2019; 95 (3): 693–707. doi: 10.1016/j.kint.2018.08.046. PMID: 30528263.Erpicum P, Weekers L, Detry O, Bonvoisin C, Delbouille MH, Grégoire C et al. Infusion of third-party mesenchymal stromal cells after kidney transplantation: a phase I–II, open-label, clinical study. Kidney Int. 2019; 95 (3): 693–707. doi: 10.1016/j.kint.2018.08.046. PMID: 30528263.Perico N, Casiraghi F, Todeschini M, Cortinovis M, Gotti E, Portalupi V et al. Long-term clinical and immunological profile of kidney transplant patients given mesenchymal stromal cell immunotherapy. Front Immunol. 2018; 9: 1359. doi: 10.3389/fimmu.2018.01359. PMID: 29963053.Perico N, Casiraghi F, Todeschini M, Cortinovis M, Gotti E, Portalupi V et al. Long-term clinical and immunological profile of kidney transplant patients given mesenchymal stromal cell immunotherapy. Front Immunol. 2018; 9: 1359. doi: 10.3389/fimmu.2018.01359. PMID: 29963053.Mudrabettu C, Kumar V, Rakha A, Yadav AK, Ramachandran R, Kanwar DB et al. Safety and efficacy of autologous mesenchymal stromal cells transplantation in patients undergoing living donor kidney transplantation: a pilot study. Nephrology (Carlton). 2015; 20 (1): 25–33. doi: 10.1111/nep.12338. PMID: 25230334.Mudrabettu C, Kumar V, Rakha A, Yadav AK, Ramachandran R, Kanwar DB et al. Safety and efficacy of autologous mesenchymal stromal cells transplantation in patients undergoing living donor kidney transplantation: a pilot study. Nephrology (Carlton). 2015; 20 (1): 25–33. doi: 10.1111/nep.12338. PMID: 25230334.Perico N, Casiraghi F, Gotti E, Introna M, Todeschini M, Cavinato RA et al. Mesenchymal stromal cells and kidney transplantation: pretransplant infusion protects from graft dysfunction while fostering immunoregulation. Transpl Int. 2013; 26 (9): 867–878. doi: 10.1111/tri.12132. PMID: 23738760.Perico N, Casiraghi F, Gotti E, Introna M, Todeschini M, Cavinato RA et al. Mesenchymal stromal cells and kidney transplantation: pretransplant infusion protects from graft dysfunction while fostering immunoregulation. Transpl Int. 2013; 26 (9): 867–878. doi: 10.1111/tri.12132. PMID: 23738760.Lee H, Park JB, Lee S, Baek S, Kim H, Kim SJ. Intra-osseous injection of donor mesenchymal stem cell (MSC) into the bone marrow in living donor kidney transplantation; a pilot study. J Transl Med. 2013; 11: 96. doi: 10.1186/1479-5876-11-96. PMID: 23578110.Lee H, Park JB, Lee S, Baek S, Kim H, Kim SJ. Intra-osseous injection of donor mesenchymal stem cell (MSC) into the bone marrow in living donor kidney transplantation; a pilot study. J Transl Med. 2013; 11: 96. doi: 10.1186/1479-5876-11-96. PMID: 23578110.Tan J, Wu W, Xu X, Liao L, Zheng F, Messinger S et al. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA. 2012; 307 (11): 1169–1177. doi: 10.1001/jama.2012.316. PMID: 22436957.Tan J, Wu W, Xu X, Liao L, Zheng F, Messinger S et al. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. JAMA. 2012; 307 (11): 1169–1177. doi: 10.1001/jama.2012.316. PMID: 22436957.Saadi G, Fadel F, El Ansary M, El-Hamid SA. Mesenchymal stem cell transfusion for desensitization of positive lymphocyte cross-match before kidney transplantation: outcome of 3 cases. Cell Prolif. 2013; 46 (2): 121–126. doi: 10.1111/cpr.12012. PMID: 23510466.Saadi G, Fadel F, El Ansary M, El-Hamid SA. Mesenchymal stem cell transfusion for desensitization of positive lymphocyte cross-match before kidney transplantation: outcome of 3 cases. Cell Prolif. 2013; 46 (2): 121–126. doi: 10.1111/cpr.12012. PMID: 23510466.Perico N, Casiraghi F, Introna M, Gotti E, Todeschini M, Cavinato RA et al. Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility. Clin J Am Soc Nephrol. 2011; 6 (2): 412–422. doi: 10.2215/ CJN.04950610. PMID: 20930086.Perico N, Casiraghi F, Introna M, Gotti E, Todeschini M, Cavinato RA et al. Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility. Clin J Am Soc Nephrol. 2011; 6 (2): 412–422. doi: 10.2215/ CJN.04950610. PMID: 20930086.Vanikar AV, Trivedi HL, Feroze A, Kanodia KV, Dave SD, Shah PR. Effect of co-transplantation of mesenchymal stem cells and hematopoietic stem cells as compared to hematopoietic stem cell transplantation alone in renal transplantation to achieve donor hypo-responsiveness. Int Urol Nephrol. 2011; 43 (1): 225–232. doi: 10.1007/s11255-009-9659-1. PMID: 20084457.Vanikar AV, Trivedi HL, Feroze A, Kanodia KV, Dave SD, Shah PR. Effect of co-transplantation of mesenchymal stem cells and hematopoietic stem cells as compared to hematopoietic stem cell transplantation alone in renal transplantation to achieve donor hypo-responsiveness. Int Urol Nephrol. 2011; 43 (1): 225–232. doi: 10.1007/s11255-009-9659-1. PMID: 20084457.Peng Y, Ke M, Xu L, Liu L, Chen X, Xia W et al. Donorderived mesenchymal stem cells combined with lowdose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study [published correction appears in Transplantation. 2014 Mar 27; 97 (6): e37. Pan, Guanghui [added]]. Transplantation. 2013; 95 (1): 161–168. doi: 10.1097/TP.0b013e3182754c53. PMID: 23263506.Peng Y, Ke M, Xu L, Liu L, Chen X, Xia W et al. Donorderived mesenchymal stem cells combined with lowdose tacrolimus prevent acute rejection after renal transplantation: a clinical pilot study [published correction appears in Transplantation. 2014 Mar 27; 97 (6): e37. Pan, Guanghui [added]]. Transplantation. 2013; 95 (1): 161–168. doi: 10.1097/TP.0b013e3182754c53. PMID: 23263506.Reinders ME, de Fijter JW, Roelofs H, Bajema IM, de Vries DK, Schaapherder AF et al. Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med. 2013; 2 (2): 107–111. doi: 10.5966/sctm.2012-0114. PMID: 23349326.Reinders ME, de Fijter JW, Roelofs H, Bajema IM, de Vries DK, Schaapherder AF et al. Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med. 2013; 2 (2): 107–111. doi: 10.5966/sctm.2012-0114. PMID: 23349326.Dave SD, Vanikar AV, Trivedi HL. Co-infusion of adipose tissue derived mesenchymal stem cell-differentiated insulin-making cells and haematopoietic cells with renal transplantation: a novel therapy for type 1 diabetes mellitus with end-stage renal disease. BMJ Case Rep. 2013; 2013: bcr2013009901. doi: 10.1136/bcr-2013-009901. PMID: 23709153.Dave SD, Vanikar AV, Trivedi HL. Co-infusion of adipose tissue derived mesenchymal stem cell-differentiated insulin-making cells and haematopoietic cells with renal transplantation: a novel therapy for type 1 diabetes mellitus with end-stage renal disease. BMJ Case Rep. 2013; 2013: bcr2013009901. doi: 10.1136/bcr-2013-009901. PMID: 23709153.Vanikar AV, Trivedi HL, Gopal SC, Kumar A, Dave SD. Pre-transplant co-infusion of donor-adipose tissue derived mesenchymal stem cells and hematopoietic stem cells may help in achieving tolerance in living donor renal transplantation. Ren Fail. 2014; 36 (3): 457–460. doi: 10.3109/0886022X.2013.868295. PMID: 24344734.Vanikar AV, Trivedi HL, Gopal SC, Kumar A, Dave SD. Pre-transplant co-infusion of donor-adipose tissue derived mesenchymal stem cells and hematopoietic stem cells may help in achieving tolerance in living donor renal transplantation. Ren Fail. 2014; 36 (3): 457–460. doi: 10.3109/0886022X.2013.868295. PMID: 24344734.Vanikar AV, Trivedi HL, Kumar A, Gopal SC, Patel HV, Gumber MR et al. Co-infusion of donor adipose tissuederived mesenchymal and hematopoietic stem cells helps safe minimization of immunosuppression in renal transplantation – single center experience. Ren Fail. 2014; 36 (9): 1376–1384. doi: 10.3109/0886022X.2014.950931. PMID: 25246338.Vanikar AV, Trivedi HL, Kumar A, Gopal SC, Patel HV, Gumber MR et al. Co-infusion of donor adipose tissuederived mesenchymal and hematopoietic stem cells helps safe minimization of immunosuppression in renal transplantation – single center experience. Ren Fail. 2014; 36 (9): 1376–1384. doi: 10.3109/0886022X.2014.950931. PMID: 25246338.Pan GH, Chen Z, Xu L, Zhu JH, Xiang P, Ma JJ et al. Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study. Oncotarget. 2016; 7 (11): 12089–12101. doi: 10.18632/oncotarget.7725. PMID: 26933811.Pan GH, Chen Z, Xu L, Zhu JH, Xiang P, Ma JJ et al. Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study. Oncotarget. 2016; 7 (11): 12089–12101. doi: 10.18632/oncotarget.7725. PMID: 26933811.Dreyer GJ, Groeneweg KE, Heidt S, Roelen DL, van Pel M, Roelofs H et al. Human leukocyte antigen selected allogeneic mesenchymal stromal cell therapy in renal transplantation: The Neptune study, a phase I single-center study. Am J Transplant. 2020; 20 (10): 2905–2915. doi: 10.1111/ajt.15910. PMID: 32277568.Dreyer GJ, Groeneweg KE, Heidt S, Roelen DL, van Pel M, Roelofs H et al. Human leukocyte antigen selected allogeneic mesenchymal stromal cell therapy in renal transplantation: The Neptune study, a phase I single-center study. Am J Transplant. 2020; 20 (10): 2905–2915. doi: 10.1111/ajt.15910. PMID: 32277568.Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Ajmone Marsan N, Bax JJ et al. Cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cell therapy with early tacrolimus withdrawal in renal tranplant recipients: an analysis of the randomized TRITON study. J Am Heart Assoc. 2021; 10 (24): e023300. doi: 10.1161/ JAHA.121.023300. PMID: 34913362.Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Ajmone Marsan N, Bax JJ et al. Cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cell therapy with early tacrolimus withdrawal in renal tranplant recipients: an analysis of the randomized TRITON study. J Am Heart Assoc. 2021; 10 (24): e023300. doi: 10.1161/ JAHA.121.023300. PMID: 34913362.Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Marsan NA, Bax JJ et al. Left atrial structural and functional response in kidney transplant recipients treated with mesenchymal stromal cell therapy and early tacrolimus withdrawal. J Am Soc Echocardiogr. 2023; 36 (2): 172–179. doi: 10.1016/j.echo.2022.10.022. PMID: 36347387.Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Marsan NA, Bax JJ et al. Left atrial structural and functional response in kidney transplant recipients treated with mesenchymal stromal cell therapy and early tacrolimus withdrawal. J Am Soc Echocardiogr. 2023; 36 (2): 172–179. doi: 10.1016/j.echo.2022.10.022. PMID: 36347387.Коротков СВ, Лебедь ОА, Смольникова ВВ, Пикиреня ИИ, Щерба АЕ, Кривенко СИ, Руммо ОО. Применение мезенхимальных стволовых клеток для лечения дисфункции трансплантата печени, вызванной хроническим отторжением. Клинический случай. Хирургия. Восточная Европа. 2022; 11 (2): 271–285. doi: 10.34883/PI.2022.11.2.010.Korotkov SV, Lebed’ OA, Smolnikova VV, Pikirenya II, Shcherba AE, Krivenko SI, Rummo OO. Application of mesenchymal stem cells for the treatment of liver graft dysfunction caused by chronic rejection. Case report. Surgery. Eastern Europe. 2022; 11 (2): 271–285. [In Russ, English abstract]. doi: 10.34883/PI.2022.11.2.010.Vandermeulen M, Mohamed-Wais M, Erpicum P, Delbouille MH, Lechanteur C, Briquet A et al. Infusion of allogeneic mesenchymal stromal cells after liver transplantation: a 5-year follow-up. Liver Transpl. 2022; 28 (4): 636–646. doi: 10.1002/lt.26323. PMID: 34605167.Vandermeulen M, Mohamed-Wais M, Erpicum P, Delbouille MH, Lechanteur C, Briquet A et al. Infusion of allogeneic mesenchymal stromal cells after liver transplantation: a 5-year follow-up. Liver Transpl. 2022; 28 (4): 636–646. doi: 10.1002/lt.26323. PMID: 34605167.Mora L, Alegre F, Rifón JJ, Marti P, Herrero JI. Treatment of graft-versus-host disease with mesenchymal cells as a complication of a liver transplantation. Rev Esp Enferm Dig. 2018; 110 (11): 734–736. doi: 10.17235/reed.2018.5672/2018. PMID: 30284904.Mora L, Alegre F, Rifón JJ, Marti P, Herrero JI. Treatment of graft-versus-host disease with mesenchymal cells as a complication of a liver transplantation. Rev Esp Enferm Dig. 2018; 110 (11): 734–736. doi: 10.17235/reed.2018.5672/2018. PMID: 30284904.Casiraghi F, Perico N, Podestà MA, Todeschini M, Zambelli M, Colledan M et al. Third-party bone marrow-derived mesenchymal stromal cell infusion before liver transplantation: a randomized controlled trial. Am J Transplant. 2021; 21 (8): 2795–2809. doi: 10.1111/ajt.16468. PMID: 33370477.Casiraghi F, Perico N, Podestà MA, Todeschini M, Zambelli M, Colledan M et al. Third-party bone marrow-derived mesenchymal stromal cell infusion before liver transplantation: a randomized controlled trial. Am J Transplant. 2021; 21 (8): 2795–2809. doi: 10.1111/ajt.16468. PMID: 33370477.Detry O, Vandermeulen M, Delbouille MH, Somja J, Bletard N, Briquet A et al. Infusion of mesenchymal stromal cells after deceased liver transplantation: a phase I–II, open-label, clinical study. J Hepatol. 2017; 67 (1): 47–55. doi: 10.1016/j.jhep.2017.03.001. PMID: 28284916.Detry O, Vandermeulen M, Delbouille MH, Somja J, Bletard N, Briquet A et al. Infusion of mesenchymal stromal cells after deceased liver transplantation: a phase I–II, open-label, clinical study. J Hepatol. 2017; 67 (1): 47–55. doi: 10.1016/j.jhep.2017.03.001. PMID: 28284916.Zhang YC, Liu W, Fu BS, Wang GY, Li HB, Yi HM et al. Therapeutic potentials of umbilical cord-derived mesenchymal stromal cells for ischemic-type biliary lesions following liver transplantation. Cytotherapy. 2017; 19 (2): 194–199. doi: 10.1016/j.jcyt.2016.11.005. PMID: 27964826.Zhang YC, Liu W, Fu BS, Wang GY, Li HB, Yi HM et al. Therapeutic potentials of umbilical cord-derived mesenchymal stromal cells for ischemic-type biliary lesions following liver transplantation. Cytotherapy. 2017; 19 (2): 194–199. doi: 10.1016/j.jcyt.2016.11.005. PMID: 27964826.Erasmus DB, Durand N, Alvarez FA, Narula T, Hodge DO, Zubair AC. Feasibility and safety of low-dose mesenchymal stem cell infusion in lung transplant recipients. Stem Cells Transl Med. 2022; 11 (9): 891–899. doi: 10.1093/stcltm/szac051. PMID: 35881142.Erasmus DB, Durand N, Alvarez FA, Narula T, Hodge DO, Zubair AC. Feasibility and safety of low-dose mesenchymal stem cell infusion in lung transplant recipients. Stem Cells Transl Med. 2022; 11 (9): 891–899. doi: 10.1093/stcltm/szac051. PMID: 35881142.Mei L, Yuwei Y, Weiping L, Zhiran X, Bingzheng F, Jibing C et al. Strategy for clinical setting of co-transplantation of mesenchymal stem cells and pancreatic islets. Cell Transplantation. 2024; 33: 9636897241259433. doi: 10.1177/09636897241259433. PMID: 38877672.Mei L, Yuwei Y, Weiping L, Zhiran X, Bingzheng F, Jibing C et al. Strategy for clinical setting of co-transplantation of mesenchymal stem cells and pancreatic islets. Cell Transplantation. 2024; 33: 9636897241259433. doi: 10.1177/09636897241259433. PMID: 38877672.Koehler N, Buhler L, Egger B, Gonelle-Gispert C. Multipotent mesenchymal stromal cells interact and support islet of Langerhans viability and function. Front Endocrinol (Lausanne). 2022; 13: 822191. doi: 10.3389/fendo.2022.822191. PMID: 35222280.Koehler N, Buhler L, Egger B, Gonelle-Gispert C. Multipotent mesenchymal stromal cells interact and support islet of Langerhans viability and function. Front Endocrinol (Lausanne). 2022; 13: 822191. doi: 10.3389/fendo.2022.822191. PMID: 35222280.Barachini S, Biso L, Kolachalam S, Petrini I, Maggio R, Scarselli M et al. Mesenchymal stem cell in pancreatic islet transplantation. Biomedicines. 2023; 11 (5): 1426. doi: 10.3390/biomedicines11051426. PMID: 37239097.Barachini S, Biso L, Kolachalam S, Petrini I, Maggio R, Scarselli M et al. Mesenchymal stem cell in pancreatic islet transplantation. Biomedicines. 2023; 11 (5): 1426. doi: 10.3390/biomedicines11051426. PMID: 37239097.Gruessner AC. A Decade of Pancreas Transplantation – A Registry Report. Uro. 2023; 3 (2): 132–150. doi: 10.3390/uro3020015.Gruessner AC. A Decade of Pancreas Transplantation – A Registry Report. Uro. 2023; 3 (2): 132–150. doi: 10.3390/uro3020015.Piemonti L. Islet transplantation. South Dartmouth (MA): MDText.com; 2020.Piemonti L. Islet transplantation. South Dartmouth (MA): MDText.com; 2020.Amer LD, Mahoney MJ, Bryant SJ. Tissue engineering approaches to cell-based type 1 diabetes therapy. Tissue engineering. 2014; 20 (5): 455–467. doi: 10.1089/ten.TEB.2013.0462. PMID: 24417705.Amer LD, Mahoney MJ, Bryant SJ. Tissue engineering approaches to cell-based type 1 diabetes therapy. Tissue engineering. 2014; 20 (5): 455–467. doi: 10.1089/ten.TEB.2013.0462. PMID: 24417705.Sevastianov VI, Baranova NV, Kirsanova LA, Ponomareva AS, Basok YB, Nemets EA, Gautier SV. Comparative analysis of the influence of extracellular matrix biomimetics on the viability and insulin-producing function of isolated pancreatic islets. J Gene Eng Bio Res. 2021; 3 (2): 17–25.Sevastianov VI, Baranova NV, Kirsanova LA, Ponomareva AS, Basok YB, Nemets EA, Gautier SV. Comparative analysis of the influence of extracellular matrix biomimetics on the viability and insulin-producing function of isolated pancreatic islets. J Gene Eng Bio Res. 2021; 3 (2): 17–25.Maffi P, Secchi A. Islet transplantation alone versus solitary pancreas transplantation: an outcome-driven choice? Curr Diab Rep. 2019; 19 (5): 26. doi: 10.1007/s11892-019-1145-2. PMID: 31025188.Maffi P, Secchi A. Islet transplantation alone versus solitary pancreas transplantation: an outcome-driven choice? Curr Diab Rep. 2019; 19 (5): 26. doi: 10.1007/s11892-019-1145-2. PMID: 31025188.Chen L, Qu J, Kalyani FS, Zhang Q, Fan L, Fang Y et al. Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications. Cell Mol Life Sci. 2022; 79 (3): 142. doi: 10.1007/s00018-021-04096-y. PMID: 35187617.Chen L, Qu J, Kalyani FS, Zhang Q, Fan L, Fang Y et al. Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications. Cell Mol Life Sci. 2022; 79 (3): 142. doi: 10.1007/s00018-021-04096-y. PMID: 35187617.Borow KM, Yaroshinsky A, Greenberg B, Perin EC. Phase 3 DREAM-HF trial of mesenchymal precursor cells in chronic heart failure. Circ Res. 2019; 125 (3): 265–281. doi: 10.1161/CIRCRESAHA.119.314951. PMID: 31318648.Borow KM, Yaroshinsky A, Greenberg B, Perin EC. Phase 3 DREAM-HF trial of mesenchymal precursor cells in chronic heart failure. Circ Res. 2019; 125 (3): 265–281. doi: 10.1161/CIRCRESAHA.119.314951. PMID: 31318648.Rodríguez-Fuentes DE, Fernández-Garza LE, SamiaMeza JA, Barrera-Barrera SA, Caplan AI, BarreraSaldaña HA. Mesenchymal stem cells current clinical applications: a systematic review. Arch Med Res. 2021; 52 (1): 93–101. doi: 10.1016/j.arcmed.2020.08.006. PMID: 32977984.Rodríguez-Fuentes DE, Fernández-Garza LE, SamiaMeza JA, Barrera-Barrera SA, Caplan AI, BarreraSaldaña HA. Mesenchymal stem cells current clinical applications: a systematic review. Arch Med Res. 2021; 52 (1): 93–101. doi: 10.1016/j.arcmed.2020.08.006. PMID: 32977984.Bonaventura G, Munafò A, Bellanca CM, La Cognata V, Iemmolo R, Attaguile GA et al. Stem cells: innovative therapeutic options for neurodegenerative diseases? Cells. 2021; 10 (8): 1992. doi: 10.3390/cells10081992. PMID: 34440761.Bonaventura G, Munafò A, Bellanca CM, La Cognata V, Iemmolo R, Attaguile GA et al. Stem cells: innovative therapeutic options for neurodegenerative diseases? Cells. 2021; 10 (8): 1992. doi: 10.3390/cells10081992. PMID: 34440761.Sevastianov VI, Basok YuB, Grigoriev AM, Nemets EA, Kirillova AD, Kirsanova LA et al. Decellularization of cartilage microparticles: Effects of temperature, supercritical carbon dioxide and ultrasound on biochemical, mechanical, and biological properties. J Biomed Mater Res A. 2023; 111 (4): 543–555. doi: 10.1002/jbm.a.37474. PMID: 36478378.Sevastianov VI, Basok YuB, Grigoriev AM, Nemets EA, Kirillova AD, Kirsanova LA et al. Decellularization of cartilage microparticles: Effects of temperature, supercritical carbon dioxide and ultrasound on biochemical, mechanical, and biological properties. J Biomed Mater Res A. 2023; 111 (4): 543–555. doi: 10.1002/jbm.a.37474. PMID: 36478378.Guillamat-Prats R. The role of MSC in wound healing, scarring and regeneration. Cells. 2021; 10 (7): 1729. doi: 10.3390/cells10071729. PMID: 34359898.Guillamat-Prats R. The role of MSC in wound healing, scarring and regeneration. Cells. 2021; 10 (7): 1729. doi: 10.3390/cells10071729. PMID: 34359898.Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022; 7 (1): 272. doi: 10.1038/s41392-022-01134-4. PMID: 35933430.Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022; 7 (1): 272. doi: 10.1038/s41392-022-01134-4. PMID: 35933430.Liu J, Gao J, Liang Z, Gao C, Niu Q, Wu F et al. Mesenchymal stem cells and their microenvironment. Stem Cell Res Ther. 2022; 13 (1): 429. doi: 10.1186/s13287-022-02985-y. PMID: 35987711.Liu J, Gao J, Liang Z, Gao C, Niu Q, Wu F et al. Mesenchymal stem cells and their microenvironment. Stem Cell Res Ther. 2022; 13 (1): 429. doi: 10.1186/s13287-022-02985-y. PMID: 35987711.Almeida-Porada G, Atala AJ, Porada CD. Therapeutic mesenchymal stromal cells for immunotherapy and for gene and drug delivery. Mol Ther Methods Clin Dev. 2020; 16: 204–224. doi: 10.1016/j.omtm.2020.01.005. PMID: 32071924.Almeida-Porada G, Atala AJ, Porada CD. Therapeutic mesenchymal stromal cells for immunotherapy and for gene and drug delivery. Mol Ther Methods Clin Dev. 2020; 16: 204–224. doi: 10.1016/j.omtm.2020.01.005. PMID: 32071924.Trigo CM, Rodrigues JS, Camões SP, Solá S, Miranda JP. Mesenchymal stem cell secretome for regenerative medicine: where do we stand? J Adv Res. 2024; S2090-1232(24)00181-4. doi: 10.1016/j.jare.2024.05.004. PMID: 38729561.Trigo CM, Rodrigues JS, Camões SP, Solá S, Miranda JP. Mesenchymal stem cell secretome for regenerative medicine: where do we stand? J Adv Res. 2024; S2090-1232(24)00181-4. doi: 10.1016/j.jare.2024.05.004. PMID: 38729561.Berebichez-Fridman R, Montero-Olvera PR. Sources and clinical applications of mesenchymal stem cells: state-of-the-art review. Sultan Qaboos Univ Med J. 2018; 18 (3): e264–e277. doi: 10.18295/squmj.2018.18.03.002. PMID: 30607265.Berebichez-Fridman R, Montero-Olvera PR. Sources and clinical applications of mesenchymal stem cells: state-of-the-art review. Sultan Qaboos Univ Med J. 2018; 18 (3): e264–e277. doi: 10.18295/squmj.2018.18.03.002. PMID: 30607265.Yang YK, Ogando CR, Wang See C, Chang TY, Barabino GA. Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro. Stem Cell Res Ther. 2018; 9 (1): 131. doi: 10.1186/s13287-018-0876-3. PMID: 29751774.Yang YK, Ogando CR, Wang See C, Chang TY, Barabino GA. Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro. Stem Cell Res Ther. 2018; 9 (1): 131. doi: 10.1186/s13287-018-0876-3. PMID: 29751774.Егорова ВА, Пономарева АС, Богданова НБ, Абрамов ВЮ, Севастьянов ВИ. Характеристика фенотипа мезенхимальных стволовых клеток из жировой ткани человека методом проточной цитометрии. Технологии живых систем. 2009; 6 (5): 40–46.Egorova VA, Ponomareva AS, Bogdanova NB, Abramov VJu, Sevastianov VI. Harakteristika fenotipa mezenhimal’nyh stvolovyh kletok iz zhirovoj tkani cheloveka metodom protochnoj citometrii. Tehnologii zhivyh sistem. 2009; 6 (5): 40–46. [In Russ].Hladik D, Höfig I, Oestreicher U, Beckers J, Matjanovski M, Bao X et al. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. Stem Cell Res Ther. 2019; 10 (1): 218. doi: 10.1186/s13287-019-1334-6. PMID: 31358047.Hladik D, Höfig I, Oestreicher U, Beckers J, Matjanovski M, Bao X et al. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. Stem Cell Res Ther. 2019; 10 (1): 218. doi: 10.1186/s13287-019-1334-6. PMID: 31358047.Deng W, Han Q, Liao L, You S, Deng H, Zhao RC. Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice. DNA Cell Biol. 2005; 24 (7): 458–463. doi: 10.1089/dna.2005.24.458. PMID: 16008514.Deng W, Han Q, Liao L, You S, Deng H, Zhao RC. Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice. DNA Cell Biol. 2005; 24 (7): 458–463. doi: 10.1089/dna.2005.24.458. PMID: 16008514.Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005; 105 (4): 1815–1822. doi: 10.1182/ blood-2004-04-1559. PMID: 15494428.Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005; 105 (4): 1815–1822. doi: 10.1182/ blood-2004-04-1559. PMID: 15494428.Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res. 2005; 305 (1): 33–41. doi: 10.1016/j.yexcr.2004.12.013. PMID: 15777785.Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res. 2005; 305 (1): 33–41. doi: 10.1016/j.yexcr.2004.12.013. PMID: 15777785.Ma OK, Chan KH. Immunomodulation by mesenchymal stem cells: interplay between mesenchymal stem cells and regulatory lymphocytes. World J Stem Cells. 2016; 8 (9): 268–278. doi: 10.4252/wjsc.v8.i9.268. PMID: 27679683.Ma OK, Chan KH. Immunomodulation by mesenchymal stem cells: interplay between mesenchymal stem cells and regulatory lymphocytes. World J Stem Cells. 2016; 8 (9): 268–278. doi: 10.4252/wjsc.v8.i9.268. PMID: 27679683.Zhao Z-G, Xu W, Sun L, You Y, Li F, Li Q-B et al. Immunomodulatory function of regulatory dendritic cells induced by mesenchymal stem cells. Immunol Invest. 2012; 41 (2): 183–198. doi: 10.3109/08820139.2011.607877. PMID: 21936678.Zhao Z-G, Xu W, Sun L, You Y, Li F, Li Q-B et al. Immunomodulatory function of regulatory dendritic cells induced by mesenchymal stem cells. Immunol Invest. 2012; 41 (2): 183–198. doi: 10.3109/08820139.2011.607877. PMID: 21936678.Rutz S, Janke M, Kassner N, Hohnstein T, Krueger M, Scheffold A. Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci USA. 2008; 105 (9): 3497–3502. doi: 10.1073/pnas.0712102105. PMID: 18292228.Rutz S, Janke M, Kassner N, Hohnstein T, Krueger M, Scheffold A. Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci USA. 2008; 105 (9): 3497–3502. doi: 10.1073/pnas.0712102105. PMID: 18292228.Cho D-I, Kim MR, Jeong H-Y, Jeong HC, Jeong MH, Yoon SH et al. Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrowderived macrophages. Exp Mol Med. 2014; 46 (1): e70. doi: 10.1038/emm.2013.135. PMID: 24406319.Cho D-I, Kim MR, Jeong H-Y, Jeong HC, Jeong MH, Yoon SH et al. Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrowderived macrophages. Exp Mol Med. 2014; 46 (1): e70. doi: 10.1038/emm.2013.135. PMID: 24406319.Sotiropoulou PA, Perez SA, Gritzapis AD, Baxevanis CN, Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells. 2006; 24 (1): 74–85. doi: 10.1634/stemcells.2004-0359. PMID: 16099998.Sotiropoulou PA, Perez SA, Gritzapis AD, Baxevanis CN, Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells. 2006; 24 (1): 74–85. doi: 10.1634/stemcells.2004-0359. PMID: 16099998.Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008; 2 (2): 141–150. doi: 10.1016/j.stem.2007.11.014. PMID: 18371435.Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008; 2 (2): 141–150. doi: 10.1016/j.stem.2007.11.014. PMID: 18371435.Kyurkchiev D, Bochev I, Ivanova-Todorova E, Mourdjeva M, Oreshkova T, Belemezova K et al. Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells. 2014; 6 (5): 552–570. doi: 10.4252/wjsc.v6.i5.552. PMID: 25426252.Kyurkchiev D, Bochev I, Ivanova-Todorova E, Mourdjeva M, Oreshkova T, Belemezova K et al. Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells. 2014; 6 (5): 552–570. doi: 10.4252/wjsc.v6.i5.552. PMID: 25426252.Gotherstrom C, Lundqvist A, Duprez IR, Childs R, Berg L, le Blanc K. Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways. Cytotherapy. 2011; 13 (3): 269–278. doi: 10.3109/14653249.2010.523077. PMID: 20942778.Gotherstrom C, Lundqvist A, Duprez IR, Childs R, Berg L, le Blanc K. Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways. Cytotherapy. 2011; 13 (3): 269–278. doi: 10.3109/14653249.2010.523077. PMID: 20942778.Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS et al. Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Sci Transl Med. 2017; 9 (416): eaam7828. doi: 10.1126/scitranslmed.aam7828. PMID: 29141887.Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS et al. Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Sci Transl Med. 2017; 9 (416): eaam7828. doi: 10.1126/scitranslmed.aam7828. PMID: 29141887.Chen W, Lv L, Chen N, Cui E. Immunogenicity of mesenchymal stromal/stem cells. Scand J Immunol. 2023; 97 (6): e13267. doi: 10.1111/sji.13267. PMID: 39007962.Chen W, Lv L, Chen N, Cui E. Immunogenicity of mesenchymal stromal/stem cells. Scand J Immunol. 2023; 97 (6): e13267. doi: 10.1111/sji.13267. PMID: 39007962.Боровкова НВ, Хубутия МШ, Ржевская ОН, Пинчук АВ, Васильченков ДА. Применение мультипотентных мезенхимальных стромальных клеток костного мозга при трансплантации почки. Трансплантология. 2019; 11 (1): 21–36. doi: 10.23873/2074-0506-2019-11-1-21-36.Borovkova NV, Khubutiya MSh, Rzhevskaya ON, Pinchuk AV, Vasil’chenkov DA. Multipotent mesenchymal stem cells in renal transplantation. Transplantologiya. The Russian Journal of Transplantation. 2019; 11 (1): 21–36. [In Russ, English abstract]. doi: 10.23873/2074-0506-2019-11-1-21-36.Preda MB, Rønningen T, Burlacu A, Simionescu M, Moskaug JØ, Valen G. Remote transplantation of mesenchymal stem cells protects the heart against ischemiareperfusion injury. Stem Cells. 2014; 32 (8): 2123–2134. doi: 10.1002/stem.1687. PMID: 24578312.Preda MB, Rønningen T, Burlacu A, Simionescu M, Moskaug JØ, Valen G. Remote transplantation of mesenchymal stem cells protects the heart against ischemiareperfusion injury. Stem Cells. 2014; 32 (8): 2123–2134. doi: 10.1002/stem.1687. PMID: 24578312.Shi W, Zhou X, Li X, Peng X, Chen G, Li Y et al. Human umbilical cord mesenchymal stem cells protect against renal ischemia-reperfusion injury by secreting extracellular vesicles loaded with miR-148b-3p that target pyruvate dehydrogenase kinase 4 to inhibit endoplasmic reticulum stress at the reperfusion stages. Int J Mol Sci. 2023; 24 (10): 8899. doi: 10.3390/ijms24108899. PMID: 37240246.Shi W, Zhou X, Li X, Peng X, Chen G, Li Y et al. Human umbilical cord mesenchymal stem cells protect against renal ischemia-reperfusion injury by secreting extracellular vesicles loaded with miR-148b-3p that target pyruvate dehydrogenase kinase 4 to inhibit endoplasmic reticulum stress at the reperfusion stages. Int J Mol Sci. 2023; 24 (10): 8899. doi: 10.3390/ijms24108899. PMID: 37240246.Saidi RF, Rajeshkumar B, Shariftabrizi A, Bogdanov AA, Zheng S, Dresser K et al. Human adipose-derived mesenchymal stem cells attenuate liver ischemia-reperfusion injury and promote liver regeneration. Surgery. 2014; 156 (5): 1225–1231. doi: 10.1016/j.surg.2014.05.008. PMID: 25262218.Saidi RF, Rajeshkumar B, Shariftabrizi A, Bogdanov AA, Zheng S, Dresser K et al. Human adipose-derived mesenchymal stem cells attenuate liver ischemia-reperfusion injury and promote liver regeneration. Surgery. 2014; 156 (5): 1225–1231. doi: 10.1016/j.surg.2014.05.008. PMID: 25262218.Qiao LY, Huang FJ, Zhao M, Xie JH, Shi J, Wang J et al. A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients. Cell Transplant. 2014; 23 Suppl 1: S65–S72. doi: 10.3727/096368914X684961. PMID: 25333752.Qiao LY, Huang FJ, Zhao M, Xie JH, Shi J, Wang J et al. A two-year follow-up study of cotransplantation with neural stem/progenitor cells and mesenchymal stromal cells in ischemic stroke patients. Cell Transplant. 2014; 23 Suppl 1: S65–S72. doi: 10.3727/096368914X684961. PMID: 25333752.Gorman E, Millar J, McAuley D, O’Kane C. Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential. Expert Rev Respir Med. 2021; 15 (3): 301–324. doi: 10.1080/17476348.2021.1848555. PMID: 33172313.Gorman E, Millar J, McAuley D, O’Kane C. Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential. Expert Rev Respir Med. 2021; 15 (3): 301–324. doi: 10.1080/17476348.2021.1848555. PMID: 33172313.Miceli V, Bulati M, Gallo A, Iannolo G, Busà R, Conaldi PG et al. Role of mesenchymal stem/stromal cells in modulating ischemia/reperfusion injury: current state of the art and future perspectives. Biomedicines. 2023; 11 (3): 689. doi: 10.3390/biomedicines11030689. PMID: 36979668.Miceli V, Bulati M, Gallo A, Iannolo G, Busà R, Conaldi PG et al. Role of mesenchymal stem/stromal cells in modulating ischemia/reperfusion injury: current state of the art and future perspectives. Biomedicines. 2023; 11 (3): 689. doi: 10.3390/biomedicines11030689. PMID: 36979668.Giai Via A, Frizziero A, Oliva F. Biological properties of mesenchymal stem cells from different sources. Muscles Ligaments Tendons J. 2012; 2 (3): 154–162. PMID: 23738292.Giai Via A, Frizziero A, Oliva F. Biological properties of mesenchymal stem cells from different sources. Muscles Ligaments Tendons J. 2012; 2 (3): 154–162. PMID: 23738292.Jones E, Schäfer R. Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species? Stem Cell Res Ther. 2015; 6 (1): 143. doi: 10.1186/s13287-015-0144-8. PMID: 26282627.Jones E, Schäfer R. Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species? Stem Cell Res Ther. 2015; 6 (1): 143. doi: 10.1186/s13287-015-0144-8. PMID: 26282627.Ganguly P, El-Jawhari JJ, Giannoudis PV, Burska AN, Ponchel F, Jones EA. Age related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development. Cell Transpl. 2017; 26 (9): 1520–1529. doi: 10.1177/0963689717721201. PMID: 29113463.Ganguly P, El-Jawhari JJ, Giannoudis PV, Burska AN, Ponchel F, Jones EA. Age related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development. Cell Transpl. 2017; 26 (9): 1520–1529. doi: 10.1177/0963689717721201. PMID: 29113463.Kaundal U, Bagai U, Rakha A. Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation. J Transl Med. 2018; 16 (1): 31. doi: 10.1186/s12967-018-1403-0. PMID: 29448956.Kaundal U, Bagai U, Rakha A. Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation. J Transl Med. 2018; 16 (1): 31. doi: 10.1186/s12967-018-1403-0. PMID: 29448956.Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004; 351 (26): 2715– 2729. doi: 10.1056/NEJMra033540. PMID: 15616206.Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med. 2004; 351 (26): 2715– 2729. doi: 10.1056/NEJMra033540. PMID: 15616206.Pilch NA, Bowman LJ, Taber DJ. Immunosuppression trends in solid organ transplantation: the future of individualization, monitoring, and management. Pharmacotherapy. 2021; 41 (1): 119–131. doi: 10.1002/phar.2481. PMID: 33131123.Pilch NA, Bowman LJ, Taber DJ. Immunosuppression trends in solid organ transplantation: the future of individualization, monitoring, and management. Pharmacotherapy. 2021; 41 (1): 119–131. doi: 10.1002/phar.2481. PMID: 33131123.Готье СВ. Иммуносупрессия при трансплантации солидных органов. М.–Тверь: Триада, 2011; 472.Готье СВ. Иммуносупрессия при трансплантации солидных органов. М.–Тверь: Триада, 2011; 472. Gautier SV. Immunosupressija pri transplantacii solidnyh organov. М.–Tver’: Triada, 2011; 472.Hajkova M, Hermankova B, Javorkova E, Bohacova P, Zajicova A, Holan V et al. Mesenchymal stem cells attenuate the adverse effects of immunosuppressive drugs on distinct T cell subopulations. Stem Cell Rev Rep. 2017; 13 (1): 104–115. doi: 10.1007/s12015-016-9703-3. PMID: 27866327.Hajkova M, Hermankova B, Javorkova E, Bohacova P, Zajicova A, Holan V et al. Mesenchymal stem cells attenuate the adverse effects of immunosuppressive drugs on distinct T cell subopulations. Stem Cell Rev Rep. 2017; 13 (1): 104–115. doi: 10.1007/s12015-016-9703-3. PMID: 27866327.Eggenhofer E, Renner P, Soeder Y, Popp FC, Hoogduijn MJ, Geissler EK et al. Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model. Transpl Immunol. 2011; 25 (2–3): 141–147. doi: 10.1016/j.trim.2011.06.002. PMID: 21704160.Eggenhofer E, Renner P, Soeder Y, Popp FC, Hoogduijn MJ, Geissler EK et al. Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model. Transpl Immunol. 2011; 25 (2–3): 141–147. doi: 10.1016/j.trim.2011.06.002. PMID: 21704160.Tatum R, O’Malley TJ, Bodzin AS, Tchantchaleishvili V. Machine perfusion of donor organs for transplantation. Artif Organs. 2021; 45 (7): 682–695. doi: 10.1111/aor.13894. PMID: 33349946.Tatum R, O’Malley TJ, Bodzin AS, Tchantchaleishvili V. Machine perfusion of donor organs for transplantation. Artif Organs. 2021; 45 (7): 682–695. doi: 10.1111/aor.13894. PMID: 33349946.Weissenbacher A, Vrakas G, Nasralla D, Ceresa CDL. The future of organ perfusion and re-conditioning. Transpl Int. 2019; 32 (6): 586–597. doi: 10.1111/tri.13441. PMID: 30980772.Weissenbacher A, Vrakas G, Nasralla D, Ceresa CDL. The future of organ perfusion and re-conditioning. Transpl Int. 2019; 32 (6): 586–597. doi: 10.1111/tri.13441. PMID: 30980772.Готье СВ, Цирульникова ОМ, Пашков ИВ, Олешкевич ДО, Филатов ИА, Богданов ВК и др. Нормотермическая ex vivo перфузия изолированных легких в эксперименте с использованием отечественного перфузионного аппаратного комплекса. Вестник трансплантологии и искусственных органов. 2022; 24 (2): 94–101. doi: 10.15825/1995-1191-2022-2-94-101.Gautier SV, Tsirulnikova OM, Pashkov IV, Oleshkevich DO, Filatov IA, Bogdanov VK et al. Normothermic ex vivo perfusion of isolated lungs in an experiment using a russian-made perfusion system. Russian Journal of Transplantology and Artificial Organs. 2022; 24 (2): 94–101. [In Russ, English abstract]. doi: 10.15825/1995-1191-2022-2-94-101.Almeida S, Snyder W, Shah M, Fisher J, Marsh C, Hawkes A et al. Revolutionizing deceased donor transplantation: how new approaches to machine perfusion broadens the horizon for organ donation. Transplantation Reports. 2024; 9 (3): 100160. doi: 10.1016/j.tpr.2024.100160.Almeida S, Snyder W, Shah M, Fisher J, Marsh C, Hawkes A et al. Revolutionizing deceased donor transplantation: how new approaches to machine perfusion broadens the horizon for organ donation. Transplantation Reports. 2024; 9 (3): 100160. doi: 10.1016/j.tpr.2024.100160.Iske J, Schroeter A, Knoedler S, Nazari-Shafti TZ, Wert L, Roesel MJ et al. Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view. Front Cardiovasc Med. 2023; 10: 1272945. doi: 10.3389/fcvm.2023.1272945. PMID: 37900569.Iske J, Schroeter A, Knoedler S, Nazari-Shafti TZ, Wert L, Roesel MJ et al. Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view. Front Cardiovasc Med. 2023; 10: 1272945. doi: 10.3389/fcvm.2023.1272945. PMID: 37900569.Brasile L, Henry N, Orlando G, Stubenitsky B. Potentiating renal regeneration using mesenchymal stem cells. Transplantation. 2019; 103 (2): 307–313. doi: 10.1097/TP.0000000000002455. PMID: 30234788.Brasile L, Henry N, Orlando G, Stubenitsky B. Potentiating renal regeneration using mesenchymal stem cells. Transplantation. 2019; 103 (2): 307–313. doi: 10.1097/TP.0000000000002455. PMID: 30234788.Sun D, Yang L, Zheng W, Cao H, Wu L, Song H. Protective effects of bone marrow mesenchymal stem cells (BMMSCS) combined with normothermic machine perfusion on liver grafts donated after circulatory death via reducing the ferroptosis of hepatocytes. Med Sci Monit. 2021; 27: e930258. doi: 10.12659/MSM.930258. PMID: 34112750.Sun D, Yang L, Zheng W, Cao H, Wu L, Song H. Protective effects of bone marrow mesenchymal stem cells (BMMSCS) combined with normothermic machine perfusion on liver grafts donated after circulatory death via reducing the ferroptosis of hepatocytes. Med Sci Monit. 2021; 27: e930258. doi: 10.12659/MSM.930258. PMID: 34112750.Nakajima D, Watanabe Y, Ohsumi A, Pipkin M, Chen M, Mordant P et al. Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation. J Heart Lung Transplant. 2019; 38 (11): 1214–1223. doi: 10.1016/j.healun.2019.07.006. PMID: 31474491.Nakajima D, Watanabe Y, Ohsumi A, Pipkin M, Chen M, Mordant P et al. Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation. J Heart Lung Transplant. 2019; 38 (11): 1214–1223. doi: 10.1016/j.healun.2019.07.006. PMID: 31474491.Bogensperger C, Hofmann J, Messner F, Resch T, Meszaros A, Cardini B et al. Ex vivo mesenchymal stem cell therapy to regenerate machine perfused organs. Int J Mol Sci. 2021; 22 (10): 5233. doi: 10.3390/ijms22105233. PMID: 34063399.Bogensperger C, Hofmann J, Messner F, Resch T, Meszaros A, Cardini B et al. Ex vivo mesenchymal stem cell therapy to regenerate machine perfused organs. Int J Mol Sci. 2021; 22 (10): 5233. doi: 10.3390/ijms22105233. PMID: 34063399.Shravage BV, Turksen K. Autophagy in stem cell maintenance and differentiation. 1st ed. Cham, Switzerland: Springer; 2022.Shravage BV, Turksen K. Autophagy in stem cell maintenance and differentiation. 1st ed. Cham, Switzerland: Springer; 2022.Sbrana FV, Cortini M, Avnet S, Perut F, Columbaro M, De Milito A et al. The role of autophagy in the maintenance of stemness and differentiation of mesenchymal stem cells. Stem Cell Rev Rep. 2016; 12: 621–633. doi: 10.1007/s12015-016-9690-4. PMID: 27696271.Sbrana FV, Cortini M, Avnet S, Perut F, Columbaro M, De Milito A et al. The role of autophagy in the maintenance of stemness and differentiation of mesenchymal stem cells. Stem Cell Rev Rep. 2016; 12: 621–633. doi: 10.1007/s12015-016-9690-4. PMID: 27696271.Hou J, Han ZP, Jing YY, Yang X, Zhang SS, Sun K et al. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis. 2013; 4 (10): e844. doi: 10.1038/cddis.2013.338. PMID: 24113178.Hou J, Han ZP, Jing YY, Yang X, Zhang SS, Sun K et al. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis. 2013; 4 (10): e844. doi: 10.1038/cddis.2013.338. PMID: 24113178.El Nashar EM, Alghamdi MA, Alasmari WA, Hussein MMA, Hamza E, Taha RI et al. Autophagy promotes the survival of adipose mesenchymal stem/stromal cells and enhances their therapeutic effects in cisplatin-induced liver injury via modulating TGF-β1/Smad and PI3K/ AKT signaling pathways. Cells. 2021; 10 (9): 2475. doi: 10.3390/cells10092475. PMID: 34572126.El Nashar EM, Alghamdi MA, Alasmari WA, Hussein MMA, Hamza E, Taha RI et al. Autophagy promotes the survival of adipose mesenchymal stem/stromal cells and enhances their therapeutic effects in cisplatin-induced liver injury via modulating TGF-β1/Smad and PI3K/ AKT signaling pathways. Cells. 2021; 10 (9): 2475. doi: 10.3390/cells10092475. PMID: 34572126.Sevastianov VI, Basok YuB. Biomimetics of extracellular matrices for cell and tissue engineered medical products. Newcastle upon Tyne, UK: Cambridge Scholars Publishing; 2023.Sevastianov VI, Basok YuB. Biomimetics of extracellular matrices for cell and tissue engineered medical products. Newcastle upon Tyne, UK: Cambridge Scholars Publishing; 2023.

The authors declare that there are no conflicts of interest present.