vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2012-3-24-30vtio-186Research ArticleКлиническая трансплантологияClinical TransplantologyHBV-ИНФЕКЦИЯ DE NOVO У ПАЦИЕНТОВ ПОСЛЕ ОРТОТОПИЧЕСКОЙ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ: КЛИНИЧЕСКАЯ И ВИРУСОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА ПАЦИЕНТОВ, ОЦЕНКА ЭФФЕКТИВНОСТИ ПРОТИВОВИРУСНОЙ ТЕРАПИИHBV-INFECTION DE NOVO AFTER ORTHOTOPIC LIVER TRANSPLANTATION: CLINICAL AND VIROLOGICAL CHARACTERISTICS, ASSESSMENT OF ANTIVIRUS THERAPY EFFECTIVENESSМаломужО. И.MalomuzhO. I.ЧеклецоваЕ. В.ChekletsovaE. V.ХизроевХ. М.КhizroyevX. M.ПецВ. А.PetsV. A.ФокинC. В.FokinS. V.ТарановВ. А.TaranovV. A.ЦирульниковаО. М.TsirulniкovaO. M.ГотьеС. В.GautierS. V.ФГБУ «ФНЦ трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, г. МоскваAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowФГБУ «ФНЦ трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, г. Москва201228052014143ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XIV No 3–20122430Copyright © Маломуж О.И., Чеклецова Е.В., Хизроев Х.М., Пец В.А., Фокин C.В., Таранов В.А., Цирульникова О.М., Готье С.В., 20122012Маломуж О.И., Чеклецова Е.В., Хизроев Х.М., Пец В.А., Фокин C.В., Таранов В.А., Цирульникова О.М., Готье С.В.Malomuzh O.I., Chekletsova E.V., Кhizroyev X.M., Pets V.A., Fokin S.V., Taranov V.A., Tsirulniкova O.M., Gautier S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/186

Изучены 11 случаев НВV-инфекции de novo, возникшей у пациентов после ортотопической транспланта- ции печени, оперированных по поводу цирроза печени невирусной этиологии. У всех обследованных ре- ципиентов при вирусологическом исследовании выявлялся НBeAg в сыворотке крови (дикий штамм ви- руса). Клиническое течение НВV-вирусной инфекции в большинстве случаев было доброкачественным. Лечение энтекавиром оказалось эффективным и привело к элиминации НВsAg (у 4 пациентов); на фоне лечения ламивудином у всех пациентов было зарегистрировано снижение уровня вирусной нагрузки, в одном случае достигнута элиминация НВsAg из сыворотки крови. 

We studied 11 cases of HBV-infection de novo in patients after orthotopic liver transplantation performed because of non-viral cirrhosis. Serum НBeAg, was revedled in all patients. In most cases clinical course of HBV-infection was benign. Treatment with entecavir was more effective than lamivudin, and brought to НBsAg elimination in 4 patients. Treatment with lamivudin led to descrease viral load in all patients and HBsAg elimination in one case. 

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The authors declare that there are no conflicts of interest present.