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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2024-3-111-116</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1805</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая трансплантология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Transplantology</subject></subj-group></article-categories><title-group><article-title>Ранние и отдаленные исходы трансплантации почек от посмертных доноров реципиентам 70 лет и старше</article-title><trans-title-group xml:lang="en"><trans-title>Early and long-term outcomes of deceased-donor kidney transplant in recipients 70 years of age and older</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-9621-520X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смирнова Виктория Владимировна</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Victoria V. Smirnova</p><p>3, Bol’shaya Sukharevskaya ploshchad, Moscow, 129090</p></bio><email xlink:type="simple">smirnovavv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмарина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmarina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шмарина Нонна Валерьевна</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Shmarinanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитриев Илья Викторович</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dmitrieviv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балкаров</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Balkarov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балкаров Аслан Галиевич</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Balkarovag@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загородникова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagorodnikova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загородникова Наталья Валерьевна</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Zagorodnikovanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виноградов</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinogradov</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виноградов Владимир Евгеньевич</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">tori_9_7@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минина</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Minina</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минина Марина Генадьевна</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">minmar50@yahoo.com</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sklifosovsky Research Institute of Emergency Care</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения города Москвы»;&#13;
ФДПО ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sklifosovsky Research Institute of Emergency Care;&#13;
Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения города Москвы»;&#13;
ФДПО ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России;&#13;
ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sklifosovsky Research Institute of Emergency Care;&#13;
Pirogov Russian National Research Medical University;&#13;
Research Institute for Healthcare Organization and Medical Management</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента Департамента здравоохранения города Москвы»;&#13;
ГБУЗ города Москвы «Городская клиническая больница № 52 Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Healthcare Organization and Medical Management;&#13;
State Budgetary Healthcare Institution City Clinical Hospital 52 of Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>БУЗ «Городская клиническая больница имени С.П. Боткина Департамента здравоохранения города Москвы», Московский городской координационный центр органного донорства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Botkin Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>14</day><month>06</month><year>2024</year></pub-date><volume>26</volume><issue>3</issue><fpage>111</fpage><lpage>116</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смирнова В.В., Шмарина Н.В., Дмитриев И.В., Балкаров А.Г., Загородникова Н.В., Виноградов В.Е., Минина М.Г., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Смирнова В.В., Шмарина Н.В., Дмитриев И.В., Балкаров А.Г., Загородникова Н.В., Виноградов В.Е., Минина М.Г.</copyright-holder><copyright-holder xml:lang="en">Smirnova V.V., Shmarina N.V., Dmitriev I.V., Balkarov A.G., Zagorodnikova N.V., Vinogradov V.E., Minina M.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1805">https://journal.transpl.ru/vtio/article/view/1805</self-uri><abstract><sec><title>Введение</title><p>Введение. Высокая распространенность хронической болезни почек оказывает отрицательное влияние на продолжительность и качество жизни пациентов, особенно в старшей возрастной группе. Прогрессирование заболевания до уровня терминальной стадии почечной недостаточности приводит к необходимости проведения диализных методов заместительной почечной терапии. У возрастных пациентов с сопутствующей коморбидной патологией диализная терапия имеет свои особенности и сложности, зачастую продлевая жизнь на непродолжительный период. Рост числа обращений пациентов 70 лет и старше с целью постановки в лист ожидания трансплантации почки (ЛОТП) ГБУЗ «НИИ скорой помощи имени Н.В. Склифосовского ДЗМ» привел к необходимости оценки результатов трансплантаций почки у данной категории больных.</p></sec><sec><title>Цель</title><p>Цель: провести анализ ранних и отдаленных исходов трансплантаций почки от посмертных доноров у реципиентов 70 лет и старше.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В ретроспективное исследование были включены 23 реципиента почки в возрасте 70 лет и старше, которым в период с 2014-го по 2023 г. в отделении трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи имени Н.В. Склифосовского ДЗМ» выполнили трансплантацию почки от посмертного донора. Выживаемость реципиентов рассчитывали по методу Каплана–Майера.</p></sec><sec><title>Результаты</title><p>Результаты. Первичную функцию трансплантата почки отметили у 16 реципиентов (69,6%), отсроченную – у 7 реципиентов (30,4%). Снижение креатинина крови менее 200 мкмоль/л после трансплантации почки отметили у 19 реципиентов (82,6%). Госпитальная, 1- и 3-летняя выживаемость реципиентов составила 96% (n = 22), 84,8% [95% ДИ 72–95] и 79% [95% ДИ 65–92] соответственно; 1- и 3-летняя выживаемость трансплантатов почки составила 84,8 [95% ДИ 72–95] и 73% [95% ДИ 59–87] соответственно.</p></sec><sec><title>Заключение</title><p>Заключение. Трансплантация почки пациентам возрастной группы 70 лет и старше является возможным методом лечения хронической болезни почек 5-й стадии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The high prevalence of chronic kidney disease (CKD) has a negative impact on the length and quality of life of patients, especially in the older age group. Renal replacement therapy is required when the disease progresses to end-stage renal failure. In elderly patients with comorbidities, dialysis therapy has its own peculiarities and challenges, often prolonging life for a short period. The increase in the number of patients aged ≥70 years requesting to be placed in the kidney transplant waitlist (KTWL) at Sklifosovsky Research Institu- te of Emergency Care has led to the need to evaluate kidney transplant (KT) outcomes in this patient cohort.</p></sec><sec><title>Objective</title><p>Objective. To analyze the early and long-term outcomes of deceased-donor KT in recipients aged ≥70 years.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The retrospective study included 23 kidney recipients aged ≥70 years who underwent a deceased-donor KT in the period from 2014 to 2023 at the Kidney and Pancreas Transplantation Department, Sklifosovsky Research Institute of Emergency Care. Recipient survival was computed using the Kaplan–Meier estimate.</p></sec><sec><title>Results</title><p>Results. Sixteen recipients (69.6%) had primary function and 7 (30.4%) had delayed function. Nineteen recipients (82.6%) showed a drop in blood creatinine below 200 μmol/L after KT. Hospital, 1- and 3-year survival were 96% (n = 22), 84.8% [95% CI 72–95] and 79% [95% CI 65–92], respectively; 1- and 3-year graft survival were 84.8 [95% CI 72–95] and 73% [95% CI 59–87], respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. KT for patients aged ≥70 is a feasible treatment option for CKD stage 5.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация почки</kwd><kwd>реципиенты почки 70 лет и старше</kwd><kwd>выживаемость реципиентов</kwd><kwd>выживаемость почечных трансплантатов</kwd><kwd>исходы трансплантации почки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>transplantation</kwd><kwd>kidney recipients aged ≥70</kwd><kwd>recipient survival</kwd><kwd>kidney graft survival</kwd><kwd>kidney transplant outcomes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The top 10 causes of death. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death [Accessed January 10, 2024].</mixed-citation><mixed-citation xml:lang="en">The top 10 causes of death. 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