vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2024-4-201-211vtio-1801Research ArticleСмежные дисциплиныRelated DisciplinesСпособ численной оценки влияния кальцификаций на биомеханику ксеноперикардиальных протезов клапанов сердцаNumerical assessment of the effect of xenopericardial bioprosthetic heart valve calcifications on its biomechanicshttps://orcid.org/0000-0003-2404-2873ОнищенкоП. С.OnishchenkoP. S.

Онищенко Павел Сергеевич

650002, Кемерово, б-р им. акад. Л.С. Барбараша, д. 6.

Тел. (3842) 34-55-86

Pavel Onishchenko

6, Barbarash boulevard, Kemerovo, 650002

onis.pavel@gmail.comhttps://orcid.org/0000-0003-3211-1250КлышниковК. Ю.KlyshnikovK. Yu.

Кемерово

Kemerovo

klyshku@kemcardio.ruХромовА. А.KhromovA. A.

Кемерово

Kemerovo

hromaa@kemcardio.ruhttps://orcid.org/0000-0001-6099-0315КостюнинА. Е.KostyuninA. E.

Кемерово

Kemerovo

kostae@kemcardio.ruhttps://orcid.org/0000-0003-4890-0393ГлушковаТ. В.GlushkovaT. V.

Кемерово

Kemerovo

glushtv@kemcardio.ruhttps://orcid.org/0000-0002-0033-9376АкентьеваТ. Н.AkentievaT. N.

Кемерово

Kemerovo

akentn@kemcardio.ruhttps://orcid.org/0000-0001-7477-3979ОвчаренкоЕ. А.OvcharenkoE. A.

Кемерово

Kemerovo

ovchea@kemcardio.ruФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian FederationГБУЗ «Кузбасский клинический кардиологический диспансер имени академика Л.С. Барбараша»РоссияKuzbass Cardiology CenterRussian Federation202428082024264201211Copyright © Онищенко П.С., Клышников К.Ю., Хромов А.А., Костюнин А.Е., Глушкова Т.В., Акентьева Т.Н., Овчаренко Е.А., 20252025Онищенко П.С., Клышников К.Ю., Хромов А.А., Костюнин А.Е., Глушкова Т.В., Акентьева Т.Н., Овчаренко Е.А.Onishchenko P.S., Klyshnikov K.Y., Khromov A.A., Kostyunin A.E., Glushkova T.V., Akentieva T.N., Ovcharenko E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1801Цель

Цель: провести пилотное исследование влияния кальцификации створчатого аппарата биопротеза клапана сердца на биомеханику и выявить взаимосвязь «напряжение в материале – дисфункция».

Материалы и методы

Материалы и методы. Объектом исследования выступили два коммерческих биопротеза митрального клапана «ЮниЛайн» 26-го и 30-го типоразмеров (ЗАО «НеоКор», Россия). Для реконструкции объемов кальция образцы подвергли микрокомпьютерному томографическому сканированию. Полученные трехмерные модели были соотнесены с протезами соответствующих размеров, и в программе инженерного анализа Abaqus CAE (Dassault Systemes, Франция) произвели проекцию на объем запирающего элемента.

Результаты

Результаты. Численное моделирование показывает значительное увеличение максимальных принципиальных напряжений в образцах до 90,8 МПа, качественное снижение открытия, а также возросшее воздействие на каркас протеза. Сопоставление эпюр напряжений численного моделирования с образцами демонстрирует связь пиковых значений амплитуд с локализацией разрывов и истончений в створчатом аппарате.

Заключение

Заключение. В представленной работе нами были продемонстрированы результаты пилотного исследования взаимосвязи биомеханики в пациент-специфическом кальцинированном митральном протезе клапана сердца «ЮниЛайн» с макроскопическим описанием эксплантированных образцов. Сравнительный этап продемонстрировал влияние величин напряжения с локализацией дисфункций створчатого аппарата.

Objective

Objective: to conduct a pilot study of the effect of bioprosthetic heart valve leaflet calcification on biomechanics and to identify the «stress in the material – dysfunction» relationship.

Materials and methods

Materials and methods. The study’s focus was on two commercially available UniLine bioprosthetic mitral valves sized 26 and 30 (NeoCor, Russia). The samples were subjected to microcomputer tomographic scanning in order to reconstruct calcium volumes. The resulting 3D models were correlated with prostheses of corresponding sizes and projected to the volume of the locking element in the Abaqus/CAE engineering analysis software (Dassault Systemes, France).

Results

Results. According to numerical modeling, the maximum principal stresses increased significantly to 90.8 MPa in the samples, the opening decreased qualitatively, and impact on the prosthetic frame increased. Comparison of stress diagrams of numerical simulation with samples demonstrates the relationship between peak amplitude and rupture and thinning localizations in the flap apparatus.

Conclusion

Conclusion. The work presented demonstrated the findings of a pilot study of the connection between biomechanics in a patient-specific calcified mitral prosthetic heart valve UniLine and macroscopic characterization of explanted samples. The comparative stage showed that stress values correlate with localization of leaflet dysfunction.

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The authors declare that there are no conflicts of interest present.