vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2024-4-46-60vtio-1795Research ArticleКлиническая трансплантологияClinical TransplantologyПериоперационная профилактика ишемически‑реперфузионного повреждения почкиPerioperative prophylaxis of renal ischemia‑reperfusion injuryПоповС. В.PopovS. V.

Санкт-Петербург

St. Petersburg

info@lucaclinic.ruГусейновР. Г.GuseinovR. G.

Санкт-Петербург

St. Petersburg

info@lucaclinic.ruСивакК. В.SivakK. V.

Санкт-Петербург

St. Petersburg

kvsivak@gmail.comПерепелицаВ. В.PerepelitsaV. V.

Санкт-Петербург

St. Petersburg

perepelitsa_vit@mail.ruБештоевА.BeshtoevA.

Санкт-Петербург

St. Petersburg

info@lucaclinic.ruЛелявинаТ. А.LelyavinaT.

Лелявина Татьяна Александровна

197341, Санкт-Петербург, ул. Аккуратова, д. 2

Тел. (981) 908-90-18

Tatiana Lelyavina

2, Akkuratova str., St. Petersburg, 197341

Phone: (981) 908-90-18

tatianalelyavina@mail.ruФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава РоссииРоссияAlmazov National Medical Research CentreRussian Federation2024280820242644660Copyright © Попов С.В., Гусейнов Р.Г., Сивак К.В., Перепелица В.В., Бештоев А., Лелявина Т.А., 20252025Попов С.В., Гусейнов Р.Г., Сивак К.В., Перепелица В.В., Бештоев А., Лелявина Т.А.Popov S.V., Guseinov R.G., Sivak K.V., Perepelitsa V.V., Beshtoev A., Lelyavina T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1795

Работа посвящена обзору обсуждаемых и предлагаемых в современной литературе способов коррекции ишемически-реперфузионного повреждения (ИРП) почек при операциях и трансплантации. Рассмотрены патофизиологические механизмы ИРП и широкий спектр предлагаемых методов уменьшения степени выраженности повреждения. Применение в комбинации таких методов, как сочетание ишемического, фармакологического пре- и посткондиционирования, продолжают разрабатываться. Отмечен высокий интерес авторов к иммунологическим и биологическим (стволовые клетки) методам коррекции как к перспективному направлению для уменьшения степени выраженности ИРП.

This paper reviews the strategies for correcting ischemia-reperfusion injury (IRI) in kidneys during surgeries and transplantation, discussed and proposed in the current literature. The pathophysiological mechanisms of IRI and a wide range of proposed methods for reducing the severity of injury are considered. The use of such techniques as the combination of ischemic, pharmacological pre- and postconditioning is still being studied. It was observed that researchers were very interested in immunological and biological (stem cell) therapeutic strategies as a potential avenue to lessen the severity of IRI.

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Нефропротективное влияние комбинации пептида, имитирующего альфа-спираль эритропоэтина-бета, и инфликсимаба при ишемически-реперфузионном повреждении почек. Вестник Волгоградского государственного медицинского университета. 2022; 19 (3): 121–127.Netrebenko AS, Elagin VV, Kostina DA, Gureev VV, Pokrovsky MV, Yakushev VI et al. Nephroprotective effect of a combination of the peptide mimicking the α-spatial structure of the β erythropoietin chain and infliximab in renal ischemia-reperfusion injury. Journal of Volgograd State Medical University. 2022; 19 (3): 121–127. doi: 10.19163/1994-9480-2022-19-3-121-127. EDN KFX-WUC.Нетребенко АС, Гуреев ВВ, Корокин МВ, Покровский МВ, Солдатов ВО, Покровская ТГ и др. Патент № 2751413 C1 РФ, МПК A61K 38/08, A61P 13/12. Способ коррекции нарушений микроциркуляции в почке пептидом, имитирующим альфа-спираль β эритропоэтина, при ишемически-реперфузионном повреждении: № 2021106163: заявл. 10.03.2021: опубл. 13.07.2021; заявитель ФГАОУ ВО «Белгородский государственный национальный исследовательский университет».Netrebenko AS, Gureev VV, Korokin MV, Pokrovskij MV, Soldatov VO, Pokrovskaya TG et al. Patent № 2751413 C1 RF, MPK A61K 38/08, A61P 13/12. Method for correcting microcirculation disorders in kidney with peptide that mimics alphahelix β of erythropoietin in ischemia-reperfusion injury: № 2021106163: applied. 10.03.2021: publ. 13.07.2021; applicant FGAOU VO «Belgorod State National Research University». EDN XYVRJJ.Костина ДА, Покровская ТГ, Покровский МВ, Гуреев ВВ, Якушев ВИ, Пересыпкина АА, Колесниченко ПД. Патент № 2678768 C1 РФ, МПК A61K 38/16, A61K 38/18, C07K 14/505. Способ профилактики ишемически-реперфузионных повреждений почек карбамилированным дарбэпоэтином в эксперименте: № 2018133675: заявл. 25.09.2018: опубл. 01.02.2019; заявитель ФГАОУ ВО «Белгородский государственный национальный исследовательский университет».Kostina DA, Pokrovskaya TG, Pokrovskij MV, Gureev VV, Yakushev VI, Peresypkina AA, Kolesnichenko PD. Patent № 2678768 C1 RF, MPK A61K 38/16, A61K 38/18, C07K 14/505. Method for preventing renal ischemia reperfusion injury by carbamylated darbepoetin in experiment: № 2018133675: applied. 25.09.2018: publ. 01.02.2019; applicant FGAOU VO «Belgorod State National Research University». EDN NVYUFM.Елагин ВВ, Братчиков ОИ, Покровский МВ, Покровская ТГ, Костина ДА, Гуреев ВВ и др. Патент № 2695333 C1 РФ, МПК A61K 38/43, A61P 13/12. 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Sochi: Plekhanovets, 2019: 184. EDN NTGBKJ.Гончаров РГ, Новоселов ВИ, Шарапов МГ. Патент № 2747121 C1 РФ, МПК A61P 39/06, C12N 15/11, C12N 15/64. Способ применения средства на основе модифицированного пероксиредоксина 2 человека для коррекции последствий ишемически-реперфузионного поражения почек: № 2020121240: заявл. 26.06.2020: опубл. 28.04.2021; заявитель Федеральный исследовательский центр «Пущинский научный центр биологических исследований Российской академии наук».Goncharov RG, Novoselov VI, Sharapov MG. Patent № 2747121 C1 RF, MPK A61P 39/06, C12N 15/11, C12N 15/64. Method of agent application based on human modified peroxyredoxin 2 for correcting consequences of ischemic-reperfusive kidney damage: № 2020121240: applied. 26.06.2020: publ. 28.04.2021; applicant Federal Research Center «Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences». EDN HXPFKH.Гордеева АЕ, Курганова ЭА, Новоселов ВИ. 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The authors declare that there are no conflicts of interest present.