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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2009-2-25-28</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-178</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая трансплантология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Transplantology</subject></subj-group></article-categories><title-group><article-title>ПРИМЕНЕНИЕ ПЛАЗМАФЕРЕЗА В ЛЕЧЕНИИ БОЛЕЗНИ КОРОНАРНЫХ АРТЕРИЙ ПЕРЕСАЖЕННОГО СЕРДЦА И ОЦЕНКА ЕГО ЭФФЕКТИВНОСТИ</article-title><trans-title-group xml:lang="en"><trans-title>THE USE OF PLASMAPHERESIS IN THE TREATMENT OF CORONARY ARTERY DISEASE OF TRANSPLANTED HEART AND EVALUATION OF ITS EFFECTIVENESS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мебония</surname><given-names>Н.З.</given-names></name><name name-style="western" xml:lang="en"><surname>Meboniya</surname><given-names>N.Z.</given-names></name></name-alternatives><email xlink:type="simple">pompi2506@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозов</surname><given-names>Б.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozov</surname><given-names>B.N.</given-names></name></name-alternatives><email xlink:type="simple">1@ru.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Остроумов</surname><given-names>Е.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostroumov</surname><given-names>E.N.</given-names></name></name-alternatives><email xlink:type="simple">1@ru.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куприянова</surname><given-names>А.Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kupriyanova</surname><given-names>A.G.</given-names></name></name-alternatives><email xlink:type="simple">1@ru.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимова</surname><given-names>Н.А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimova</surname><given-names>N.A.</given-names></name></name-alternatives><email xlink:type="simple">1@ru.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ «Федеральный научный центр трансплантологии и искусственных органов&#13;
имени академика В.И. Шумакова» Минздравсоцразвития РФ, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2009</year></pub-date><volume>11</volume><issue>2</issue><fpage>25</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мебония Н., Морозов Б., Остроумов Е., Куприянова А., Максимова Н., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Мебония Н., Морозов Б., Остроумов Е., Куприянова А., Максимова Н.</copyright-holder><copyright-holder xml:lang="en">Meboniya N., Morozov B., Ostroumov E., Kupriyanova A., Maksimova N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/178">https://journal.transpl.ru/vtio/article/view/178</self-uri><abstract><p>В работе представлен опыт применения плазмаферезов в лечении БКА наряду с медикаментозной терапией. 19 реципиентам в разные сроки после трансплантации сердца с БКА, подтвержденной ангиографически, проводили курсы лечебного плазмафереза. Эффективность последнего оценивали радиоизотопными, иммуноморфологическими и лабораторными методами. После проведенного курса отмечались увеличение региональной и локальной сократимости миокарда, рост ФВ левого желудочка, снижение внутрижелудочковой асинхронии, разрешение иммунокомплексного синдрома и отсутствие локального внутрисосудистого свертывания крови. Плазмаферез рассматривается как перспективный метод воздействия на факторы, способствующие ускоренному характеру развития поражения коронарных артерий в трансплантированном сердце.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents the experience with plasmapheresis in the treatment of сoronary artery disease with drug therapy. 19 recipients at different time after cardiac transplantation with coronary artery disease confi rmed by angiography were treated by therapeutic plasmapheresis courses. The effectiveness was estimated by radioisotope, immunomorphological and laboratory methods. After the course there were increase of regional and local myocardium contractility, increase in left ventricle ejection fraction, reducing intraventricular asynchrony, permission immunocomplex syndrome and lack of local intravascular blood coagulation. Plasmapheresis is considered as a promising method for the impact on the factors contributing to the accelerated nature of the development of coronary arteries lesions in transplanted heart.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантат сердца</kwd><kwd>болезнь коронарных артерий (БКА)</kwd><kwd>плазмаферез (ПФ)</kwd><kwd>сцинтиграфия миокарда</kwd><kwd>иммунокомплексный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>transplanted heart</kwd><kwd>coronary artery disease</kwd><kwd>plasmapheresis</kwd><kwd>myocardium scintigraphy</kwd><kwd>immunocomplex syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шумаков В.И., Остроумов Е.Н., Сонин С.А. и др. Радионуклидная вентрикулография в оценке функции</mixed-citation><mixed-citation xml:lang="en">Шумаков В.И., Остроумов Е.Н., Сонин С.А. и др. 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