vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2024-3-56-65vtio-1765Research ArticleКлиническая трансплантологияClinical TransplantologyМукормикоз у реципиентов трансплантатов внутренних органов (описание клинических случаев и обзор литературы)Mucormycosis in solid organ transplant recipients (clinical cases and literature review)ХостелидиС. Н.KhostelidiS. N.

Хостелиди Софья Николаевна - д.м.н., доцент кафедры клинической микологии, аллергологии и иммунологии 

194291, Санкт-Петербург, ул. Сантьяго-де-Куба, д. 1/28

Sofya N. Khostelidi

1/28, Santiago de Cuba str., St. Petersburg, 194291

sofianic@mail.ruКозловаО. П.KozlovaO. P.

Санкт-Петербург

St. Petersburg

ШагдилееваЕ. В.ShagdileevaE. V.

Санкт-Петербург

St. Petersburg

СеменоваЕ. В.SemenovaE. V.

Санкт-Петербург

St. Petersburg

КвиткоЭ. М.KvitkoE. M.

Казань

Kazan

БердниковаА. В.BerdnikovaA. V.

Казань

Kazan

ОсокинаР. А.OsokinaR. A.

Москва

Moscow

АвдеенкоЮ. Л.AvdeenkoYu. L.

Санкт-Петербург

St. Petersburg

ТараскинаА. Е.TaraskinaA. E.

Санкт-Петербург

St. Petersburg

ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical UniversityRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России; ГБУЗ «Ленинградская областная клиническая больница»РоссияNorth-Western State Medical University; Leningrad Regional Clinical HospitalRussian FederationГАУЗ «Детская республиканская клиническая больница Министерства здравоохранения Республики Татарстан»РоссияChildren’s Republican Clinical HospitalRussian FederationФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии имени А.Н. Бакулева» Минздрава РоссииРоссияBakulev National Medical Research Center for Cardiovascular SurgeryRussian Federation2024030520242635665Copyright © Хостелиди С.Н., Козлова О.П., Шагдилеева Е.В., Семенова Е.В., Квитко Э.М., Бердникова А.В., Осокина Р.А., Авдеенко Ю.Л., Тараскина А.Е., 20242024Хостелиди С.Н., Козлова О.П., Шагдилеева Е.В., Семенова Е.В., Квитко Э.М., Бердникова А.В., Осокина Р.А., Авдеенко Ю.Л., Тараскина А.Е.Khostelidi S.N., Kozlova O.P., Shagdileeva E.V., Semenova E.V., Kvitko E.M., Berdnikova A.V., Osokina R.A., Avdeenko Y.L., Taraskina A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1765

Мукормикоз – тяжелая микотическая инфекция, сопровождаемая высокой летальностью у иммуноком- прометированных пациентов. Частота развития мукормикоза у реципиентов трансплантатов солидных органов составляет 2–8% от всех инвазивных грибковых инфекций. В большинстве случаев мукормикоз возникает в поздний посттрансплантационный период. Факторами риска у данной когорты пациентов являются РТПХ и применение иммуносупрессивных препаратов. В статье описаны клинические случаи мукормикоза и приведен анализ литературных данных, посвященных проблеме инвазивного мукормикоза у реципиентов трансплантатов солидных органов, а также рассмотрены основные методы диагностики и лечения заболевания согласно международным рекомендациям.

Mucormycosis is a severe mycotic infection with high mortality among immunocompromised patients. Its in- cidence in solid organ transplant recipients is 2–8% of all invasive fungal infections. In most cases, it occurs in the late posttransplant period. Risk factors in this patient cohort are graft-versus-host disease (GvHD) and use of immunosuppressive drugs. The article describes clinical cases of mucormycosis and analysis of literature data on the problem of invasive mucormycosis in solid organ transplant recipients. It also reviews the main methods of diagnosis and treatment of the disease according to international guidelines.

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The authors declare that there are no conflicts of interest present.