vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2024-1-47-54vtio-1740Research ArticleКлиническая трансплантологияClinical TransplantologyИзготовление стента с лекарственным покрытием эверолимусом из термопластического полиуретана и полилактида с применением технологии 3D-печатиFabrication of a 3D printed everolimus-eluting stent made of thermoplastic polyurethane and polylactideБековМ. Т.BekovM. T.

123182, Москва, ул. Щукинская, д. 1

1, Shcukinskaya str., Moscow, 123182

doctorbekov@gmail.comПашковИ. В.PashkovI. V.

123182, Москва, ул. Щукинская, д. 1

1, Shcukinskaya str., Moscow, 123182

СмирновК. С.SmirnovK. S.

123182, Москва, ул. Щукинская, д. 1

1, Shcukinskaya str., Moscow, 123182

ЯкунинЯ. С.YakuninYa. S.

123182, Москва, ул. Щукинская, д. 1

1, Shcukinskaya str., Moscow, 123182

ШилкинД. Н.ShilkinD. N.

Москва

Moscow

ЧащинИ. С.ChashchinI. S.

Москва

Moscow

ИвановаН. М.IvanovaN. M.

Москва

Moscow

ЦирульниковаО. М.TsirulnikovaO. M.

123182, Москва, ул. Щукинская, д. 1

1, Shcukinskaya str., Moscow, 123182

ГотьеС. В.GautierS. V.

123182, Москва, ул. Щукинская, д. 1

1, Shcukinskaya str., Moscow, 123182

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр сердечно-сосудистой хирургии имени А.Н. Бакулева» Минздрава РоссииРоссияBakulev Scientific Center of Cardiovascular SurgeryRussian FederationФГБУН «Институт элементоорганических соединений имени А.Н. Несмеянова» Российской академии наукРоссияNesmeyanov Institute of Organoelement CompoundsRussian FederationФГБУН «Институт органической химии имени Н.Д. Зелинского» Российской академии наукРоссияZelinsky Institute of Organic ChemistryRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityRussian Federation2024220120242614754Copyright © Беков М.Т., Пашков И.В., Смирнов К.С., Якунин Я.С., Шилкин Д.Н., Чащин И.С., Иванова Н.М., Цирульникова О.М., Готье С.В., 20242024Беков М.Т., Пашков И.В., Смирнов К.С., Якунин Я.С., Шилкин Д.Н., Чащин И.С., Иванова Н.М., Цирульникова О.М., Готье С.В.Bekov M.T., Pashkov I.V., Smirnov K.S., Yakunin Y.S., Shilkin D.N., Chashchin I.S., Ivanova N.M., Tsirulnikova O.M., Gautier S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1740

Бронхиальные стенозы являются одним из самых частых бронхиальных осложнений, возникающих у реципиентов легких в послеоперационном периоде. Одним из основных методов восстановления проходимости дыхательных путей является стентирование бронхиального дерева. Однако стентирование бронхов сопряжено с рядом осложнений, таких как миграция стента, рост грануляционных тканей по проксимальному и дистальному краям, обтурация просвета мокротой. В данной статье продемонстрирована возможность изготовления стента с лекарственным покрытием эверолимусом из термопластического полиуретана и полилактида с применением технологии 3D-печати.

Bronchial stenoses are one of the most common airways complications after lung transplantation. One of the main methods to restore airway patency is bronchial stenting. However, bronchial stenting is associated with a number of complications, such as stent migration, granulation tissue formation along the proximal and distal edges, and mucus obstruction of the lumen. This article demonstrates the possibility of manufacturing an everolimus-eluting stent from thermoplastic polyurethane and polylactide using 3D printing.

трансплантация легкихбронхиальные осложнениябронхиальные стенозыстентирование бронховсиликоновые стентыметаллические стентыбиодеградируемые стенты3D-печатьстенты с лекарственным покрытиемlung transplantationairways complicationsbronchial stenosisbronchial stentingsilicone stentsmetal stentsbioresorbable stents3D printingdrug-eluting stentsАвторы благодарят отдел структурных исследований ИОХ РАН за исследование образцов методом электронной микроскопии.ReferencesMahajan AK, Folch E, Khandhar SJ, Channick CL, Santacruz JF, Mehta AC, Nathan SD. The diagnosis and management of airway complications following lung transplantation. Chest. 2017 Sep; 152 (3): 627–638. doi: 10.1016/j.chest.2017.02.021.Mahajan AK, Folch E, Khandhar SJ, Channick CL, Santacruz JF, Mehta AC, Nathan SD. The diagnosis and management of airway complications following lung transplantation. 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The authors declare that there are no conflicts of interest present.