vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2024-3-124-133vtio-1736Research ArticleКлиническая трансплантологияClinical TransplantologyВК-вирусная нефропатия при трансплантации почки (обзор литературы)BK virus nephropathy in kidney transplantation (literature reviewПоповС. В.PopovS. V.

Попов Сергей Валерьевич

Санкт-Петербург

St. Petersburg

info@lucaclinic.ruГусейновР. Г.HuseynovR. G.

Гусейнов Руслан Гусейнович

Санкт-Петербург

St. Petersburg

info@lucaclinic.ruСивакК. В.SivakK. V.

Сивак Константин Владимирович

Санкт-Петербург

St. Petersburg

kvsivak@gmail.comИсакова-СивакИ. Н.Isakova-SivakI. N.

Санкт-Петербург

St. Petersburg

info@lucaclinic.ruПерепелицаВ. В.PerepelitsaV. V.

Перепелица Виталий Владимирович

Санкт-Петербург

St. Petersburg

perepelitsa_vit@mail.ruЛелявинаТ. А.LelyavinaT. A.

Лелявина Татьяна Александровна

197341, Санкт-Петербург, ул. Аккуратова, д. 2

Tatyana A. Lelyavina

2, Akkuratova str., St. Petersburg, 197341

tatianalelyavina@mail.ruСПб ГБУЗ «Клиническая больница Святителя Луки»; ФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова»РоссияSt. Luke’s Clinical Hospital; Kirov Military Medical AcademyRussian FederationСПб ГБУЗ «Клиническая больница Святителя Луки»; ФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияSt. Luke’s Clinical Hospital; St. Petersburg State UniversityRussian FederationСПб ГБУЗ «Клиническая больница Святителя Луки»; ФГБУ «Научно-исследовательский институт гриппа имени А.А. Смородинцева» Минздрава РоссииРоссияSt. Luke’s Clinical Hospital; Smorodintsev Research Institute of InfluenzaRussian FederationСПб ГБУЗ «Клиническая больница Святителя Луки»РоссияSt. Luke’s Clinical HospitalRussian FederationСПб ГБУЗ «Клиническая больница Святителя Луки»; ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова» Минздрава РоссииРоссияSt. Luke’s Clinical Hospital; Almazov National Medical Research CentreRussian Federation202419072024263124133Copyright © Попов С.В., Гусейнов Р.Г., Сивак К.В., Исакова-Сивак И.Н., Перепелица В.В., Лелявина Т.А., 20242024Попов С.В., Гусейнов Р.Г., Сивак К.В., Исакова-Сивак И.Н., Перепелица В.В., Лелявина Т.А.Popov S.V., Huseynov R.G., Sivak K.V., Isakova-Sivak I.N., Perepelitsa V.V., Lelyavina T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1736

В статье представлен обзор литературы, посвященной актуальной проблеме современной трансплантологии – ВК-вирусной нефропатии после нефротрансплантации. Отражены факторы риска реактивации ВК-вируса у иммунокомпрометированных пациентов. Рассмотрены вопросы скрининга и диагностики ВК-вирусной инфекции у лиц с трансплантированной почкой. Подчеркивается роль ВК-вирусной нефропатии в утрате почечного трансплантата. Обсуждены клинические проявления и стратегии лечения ВК-вирусной нефропатии при трансплантации почки.

 

The article presents a review of the literature on the current problem of modern transplantology – BK viral nephropathy after nephrotransplantation. Risk factors for BK virus reactivation in immunocompromised patients are reflected. The issues of screening and diagnosis of BK viral infection in people with a transplanted kidney are considered. The role of BK viral nephropathy in renal graft loss is emphasized. The clinical manifestations and treatment strategies of BK viral nephropathy in kidney transplantation are discussed.

ВК-вирусполиомавирустрансплантация почкиВК-вирусная нефропатиядиагностикалечение.BKVpolyomaviruskidney transplantationBK viral nephropathydiagnosistreatmentReferencesHirsch HH, Mengel M, Kamar N. BK Polyomavirus Consensus. Clin Infect Dis. 2022; 75 (11): 2046–2047. doi: 10.1093/cid/ciac594.С1. Hirsch HH, Mengel M, Kamar N. BK Polyomavirus Consensus. Clin Infect Dis. 2022; 75 (11): 2046–2047. doi: 10.1093/cid/ciac594.Blackard JT, Davies SM, Laskin BL. BK polyomavirus diversity-Why viral variation matters. Rev Med Virol. 2020; 30 (4): e2102. doi: 10.1002/rmv.2102.Blackard JT, Davies SM, Laskin BL. BK polyomavirus diversity-Why viral variation matters. Rev Med Virol. 2020; 30 (4): e2102. doi: 10.1002/rmv.2102.Solis M, Gallais F, Velay A, Fafi-Kremer S. Le virus BK et physiopathologie des maladies associées [BK-virus and pathophysiology of associated diseases]. Virologie (Montrouge). 2019; 23 (1): 7–22. French. doi: 10.1684/vir.2019.0757.Solis M, Gallais F, Velay A, Fafi-Kremer S. Le virus BK et physiopathologie des maladies associées [BK-virus and pathophysiology of associated diseases]. Virologie (Montrouge). 2019; 23 (1): 7–22. French. doi: 10.1684/vir.2019.0757.Kotla SK, Kadambi PV, Hendricks AR, Rojas R. BK polyomavirus-pathogen, paradigm and puzzle. Nephrol Dial Transplant. 202; 36 (4): 587–593. doi: 10.1093/ndt/gfz273.Kotla SK, Kadambi PV, Hendricks AR, Rojas R. BK polyomavirus-pathogen, paradigm and puzzle. Nephrol Dial Transplant. 202; 36 (4): 587–593. doi: 10.1093/ndt/gfz273.Masset C, Le Turnier P, Bressollette-Bodin C, Renaudin K, Raffi F, Dantal J. Virus-Associated Nephropathies: A Narrative Review. Int J Mol Sci. 2022; 23 (19): 12014. doi: 10.3390/ijms231912014.Masset C, Le Turnier P, Bressollette-Bodin C, Renaudin K, Raffi F, Dantal J. Virus-Associated Nephropathies: A Narrative Review. Int J Mol Sci. 2022; 23 (19): 12014. doi: 10.3390/ijms231912014.Krajewski W, Kamińska D, Poterek A, Małkiewicz B, Kłak J, Zdrojowy R et al. Pathogenicity of BK virus on the urinary system. Cent European J Urol. 2020; 73 (1): 94–103. doi: 10.5173/ceju.2020.0034.Krajewski W, Kamińska D, Poterek A, Małkiewicz B, Kłak J, Zdrojowy R et al. Pathogenicity of BK virus on the urinary system. Cent European J Urol. 2020; 73 (1): 94–103. doi: 10.5173/ceju.2020.0034.Prezioso C, Pietropaolo V. BK Virus and Transplantation. Viruses. 2021; 13 (5): 733. doi: 10.3390/v13050733.Prezioso C, Pietropaolo V. BK Virus and Transplantation. Viruses. 2021; 13 (5): 733. doi: 10.3390/v13050733.Agrawal A, Ison MG, Danziger-Isakov L. Long-Term Infectious Complications of Kidney Transplantation. Clin J Am Soc Nephrol. 2022; 17 (2): 286–295. doi: 10.2215/CJN.15971020.Agrawal A, Ison MG, Danziger-Isakov L. Long-Term Infectious Complications of Kidney Transplantation. Clin J Am Soc Nephrol. 2022; 17 (2): 286–295. doi: 10.2215/CJN.15971020.Chen X-T, Yang S-C, Chen W-F, Li J, Deng S-X, Qiu J et al. Glomerular Parietal Epithelial Cells Infection Is Associated With Poor Graft Outcome in Kidney Transplant Recipients With BK Polyomavirus-Associated Nephropathy. J Infect Dis. 2019; 219: 1879–1886. doi: 10.1093/infdis/jiz022.Chen X-T, Yang S-C, Chen W-F, Li J, Deng S-X, Qiu J et al. Glomerular Parietal Epithelial Cells Infection Is Associated With Poor Graft Outcome in Kidney Transplant Recipients With BK Polyomavirus-Associated Nephropathy. J Infect Dis. 2019; 219: 1879–1886. doi: 10.1093/infdis/jiz022.Raupp FVV, Meinerz G, da Silva CK, Bianco PCD, Goldani JC, Pegas KL et al. BK Polyomavirus-associated nephropathy managed by screening policy in a reallife setting. Transpl Infect Dis. 2020; 22 (1): e13213. doi: 10.1111/tid.13213.Raupp FVV, Meinerz G, da Silva CK, Bianco PCD, Goldani JC, Pegas KL et al. BK Polyomavirus-associated nephropathy managed by screening policy in a reallife setting. Transpl Infect Dis. 2020; 22 (1): e13213. doi: 10.1111/tid.13213.Ji J, Feng S, Jiang Y, Wang W, Zhang X. Prevalence and Risk Factors of BK Viremia and Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients: A Single-Center Cross-Sectional Study. Exp Clin Transplant. 2019; 17 (6): 727–731. doi: 10.6002/ect.2018.0262.Ji J, Feng S, Jiang Y, Wang W, Zhang X. Prevalence and Risk Factors of BK Viremia and Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients: A Single-Center Cross-Sectional Study. Exp Clin Transplant. 2019; 17 (6): 727–731. doi: 10.6002/ect.2018.0262.Zakaria ZE, Elokely AM, Ghorab AA, Bakr AI, Halim MA, Gheith OA et al. Screening for BK Viremia/ Viruria and the Impact of Management of BK Virus Nephropathy in Renal Transplant Recipients. Exp Clin Transplant. 2019; 17 (Suppl 1): 83–91. doi: 10.6002/ect.MESOT2018.O17.Zakaria ZE, Elokely AM, Ghorab AA, Bakr AI, Halim MA, Gheith OA et al. Screening for BK Viremia/ Viruria and the Impact of Management of BK Virus Nephropathy in Renal Transplant Recipients. Exp Clin Transplant. 2019; 17 (Suppl 1): 83–91. doi: 10.6002/ect.MESOT2018.O17.Thorndyke A, Joyce C, Samra M, Cotiguala L, Trotter C, Aguirre O et al. Risk Factors for CMV and BK Infections in an Elderly Veteran Population Following Kidney Transplantation: Implications for Immunosuppression Induction and Management. Biomedicines. 2023; 11 (11): 3060. doi: 10.3390/biomedicines11113060.Thorndyke A, Joyce C, Samra M, Cotiguala L, Trotter C, Aguirre O et al. Risk Factors for CMV and BK Infections in an Elderly Veteran Population Following Kidney Transplantation: Implications for Immunosuppression Induction and Management. Biomedicines. 2023; 11 (11): 3060. doi: 10.3390/biomedicines11113060.Munjal RS, Munjal J, Gandhi P, Gupta N. BK Polyomavirus-Induced Nephropathy in Native Kidney. Cureus. 2023; 15 (1): e34410. doi: 10.7759/cureus.34410.Munjal RS, Munjal J, Gandhi P, Gupta N. BK Polyomavirus-Induced Nephropathy in Native Kidney. Cureus. 2023; 15 (1): e34410. doi: 10.7759/cureus.34410.Shah A, Kumar V, Palmer MB, Trofe-Clark J, Laskin B, Sawinski D et al. Native Kidney BK Virus Nephropathy, a Systematic Review. Transpl Infect Dis. 2019; 21: e13083. doi: 10.1111/tid.13083.Shah A, Kumar V, Palmer MB, Trofe-Clark J, Laskin B, Sawinski D et al. Native Kidney BK Virus Nephropathy, a Systematic Review. Transpl Infect Dis. 2019; 21: e13083. doi: 10.1111/tid.13083.Kant S, Dasgupta A, Bagnasco S, Brennan DC. BK Virus Nephropathy in Kidney Transplantation: A State-of-theArt Review. Viruses. 2022; 14 (8): 1616. doi: 10.3390/v14081616.Kant S, Dasgupta A, Bagnasco S, Brennan DC. BK Virus Nephropathy in Kidney Transplantation: A State-of-theArt Review. Viruses. 2022; 14 (8): 1616. doi: 10.3390/v14081616.Imlay H, Whitaker K, Fisher CE, Limaye AP. Clinical characteristics and outcomes of late-onset BK virus nephropathy in kidney and kidney-pancreas transplant recipients. Transpl Infect Dis. 2018; 20: e12928. doi: 10.1111/tid.12928.Imlay H, Whitaker K, Fisher CE, Limaye AP. Clinical characteristics and outcomes of late-onset BK virus nephropathy in kidney and kidney-pancreas transplant recipients. Transpl Infect Dis. 2018; 20: e12928. doi: 10.1111/tid.12928.Demey B, Tinez C, François C, Helle F, Choukroun G, Duverlie G et al. Risk factors for BK virus viremia and nephropathy after kidney transplantation: A systematic review. J Clin Virol. 2018; 109: 6–12. doi: 10.1016/j.jcv.2018.10.002.Demey B, Tinez C, François C, Helle F, Choukroun G, Duverlie G et al. Risk factors for BK virus viremia and nephropathy after kidney transplantation: A systematic review. J Clin Virol. 2018; 109: 6–12. doi: 10.1016/j.jcv.2018.10.002.Alonso M, Villanego F, OrellanaC, Vigara LA, Montiel N, Aguilera A et al. Impact of BK Polyomavirus Plasma Viral Load in Kidney Transplant Outcomes. Transplant Proc. 2022; 54 (9): 2457–2461. doi: 10.1016/j.transproceed.2022.10.012.Alonso M, Villanego F, OrellanaC, Vigara LA, Montiel N, Aguilera A et al. Impact of BK Polyomavirus Plasma Viral Load in Kidney Transplant Outcomes. Transplant Proc. 2022; 54 (9): 2457–2461. doi: 10.1016/j.transproceed.2022.10.012.Wang J, Li J, Chen Z, Xu M, Yang C, Rong R et al. A Nomogram for Predicting BK Virus Activation in Kidney Transplantation Recipients Using Clinical Risk Factors. Front Med (Lausanne). 2022; 9: 770699. doi: 10.3389/fmed.2022.770699.Wang J, Li J, Chen Z, Xu M, Yang C, Rong R et al. A Nomogram for Predicting BK Virus Activation in Kidney Transplantation Recipients Using Clinical Risk Factors. Front Med (Lausanne). 2022; 9: 770699. doi: 10.3389/fmed.2022.770699.McCaffrey J, Bhute VJ, Shenoy M. BK virus infection and outcome following kidney transplantation in childhood. Sci Rep. 2021; 11 (1): 2468. doi: 10.1038/s41598-021-82160-0.McCaffrey J, Bhute VJ, Shenoy M. BK virus infection and outcome following kidney transplantation in childhood. Sci Rep. 2021; 11 (1): 2468. doi: 10.1038/s41598-021-82160-0.Hirsch HH, Randhawa PS. AST Infectious Diseases Community of Practice BK polyomavirus in solid organ transplantation – Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019; 33: e13528. doi: 10.1111/ctr.13528.Hirsch HH, Randhawa PS. AST Infectious Diseases Community of Practice BK polyomavirus in solid organ transplantation – Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019; 33: e13528. doi: 10.1111/ctr.13528.Van Gelder T. How cyclosporine reduces mycophenolic acid exposure by 40% while other calcineurin inhibitors do not. Kidney Int. 2021; 100: 1185–1189. doi: 10.1016/j.kint.2021.06.036.Van Gelder T. How cyclosporine reduces mycophenolic acid exposure by 40% while other calcineurin inhibitors do not. Kidney Int. 2021; 100: 1185–1189. doi: 10.1016/j.kint.2021.06.036.Turgut D, Sayin B, Soy EA, Topcu Dİ, Ozdemir BH, Haberal M. Tacrolimus intrapatient variability in BK virus nephropathy and chronic calcineurin toxicity in kidney transplantation. Saudi J Kidney Dis Transpl. 2021; 32 (2): 348–354. doi: 10.4103/1319-2442.335446.Turgut D, Sayin B, Soy EA, Topcu Dİ, Ozdemir BH, Haberal M. Tacrolimus intrapatient variability in BK virus nephropathy and chronic calcineurin toxicity in kidney transplantation. Saudi J Kidney Dis Transpl. 2021; 32 (2): 348–354. doi: 10.4103/1319-2442.335446.Tan SK, Huang C, Sahoo MK, Weber J, Kurzer J, Stedman MR et al. Impact of Pretransplant Donor BK Viruria in Kidney Transplant Recipients. J Infect Dis. 2019; 220: 370–376. doi: 10.1093/infdis/jiz114.Tan SK, Huang C, Sahoo MK, Weber J, Kurzer J, Stedman MR et al. Impact of Pretransplant Donor BK Viruria in Kidney Transplant Recipients. J Infect Dis. 2019; 220: 370–376. doi: 10.1093/infdis/jiz114.Chong S, Antoni M, Macdonald A, Reeves M, Harber M, Magee CN. BK virus: Current understanding of pathogenicity and clinical disease in transplantation. Rev Med Virol. 2019; 29: e2044. doi: 10.1002/rmv.2044.Chong S, Antoni M, Macdonald A, Reeves M, Harber M, Magee CN. BK virus: Current understanding of pathogenicity and clinical disease in transplantation. Rev Med Virol. 2019; 29: e2044. doi: 10.1002/rmv.2044.Avcı B, Baskın E, Gülleroğlu K, Ecevit Z, Ayvazoğlu Soy E, Moray G et al. BK Polyomavirus Infection and Risk Factors in Pediatric Patients Undergoing Kidney Transplant. Exp Clin Transplant. 2022; 20 (Suppl 3): 105–111. doi: 10.6002/ect.PediatricSymp2022.O34.Avcı B, Baskın E, Gülleroğlu K, Ecevit Z, Ayvazoğlu Soy E, Moray G et al. BK Polyomavirus Infection and Risk Factors in Pediatric Patients Undergoing Kidney Transplant. Exp Clin Transplant. 2022; 20 (Suppl 3): 105–111. doi: 10.6002/ect.PediatricSymp2022.O34.Ramaswamy K, Madariaga HM, Zheng L, Thomas B, Lerma EV. Donor derived infections in kidney transplant. Dis Mon. 2022; 68 (12): 101330. doi: 10.1016/j.disamonth.2022.101330.Ramaswamy K, Madariaga HM, Zheng L, Thomas B, Lerma EV. Donor derived infections in kidney transplant. Dis Mon. 2022; 68 (12): 101330. doi: 10.1016/j.disamonth.2022.101330.Hall IE, Reese PP, Mansour SG, Mohan S, Jia Y, Thiessen-Philbrook HR et al. Deceased-Donor Acute Kidney Injury and BK Polyomavirus in Kidney Transplant Recipients. Clin J Am Soc Nephrol. 2021; 16 (5): 765–775. doi: 10.2215/CJN.18101120.Hall IE, Reese PP, Mansour SG, Mohan S, Jia Y, Thiessen-Philbrook HR et al. Deceased-Donor Acute Kidney Injury and BK Polyomavirus in Kidney Transplant Recipients. Clin J Am Soc Nephrol. 2021; 16 (5): 765–775. doi: 10.2215/CJN.18101120.Матвеев А, Рагимов А, Каабак М, Дашкова Н, Салимов Э, Бабенко Н, Матвеева Н. Мониторинг ВКвируса у реципиентов в течение 1-го года после аллогенной трансплантации почки. Врач. 2018; 29 (5): 84–87. doi: 10.29296/25877305-2018-05-20.Matveev A, Ragimov A, Kaabak M, Dashkova N, Salimov E, Babenko N, Matveeva N. Monitoring of BK virus in recipients within one year after allogeneic kidney transplantation. Vrach. 2018; 29 (5): 84–86. doi: 10.29296/25877305-2018-05-20. [In Russ, English abstract].Sánchez DM, García LJ, Jiménez IL, Luján IS, Soriano MG, Viñas SL et al. Renal Function Impairment in Kidney Transplantation: Importance of Early BK Virus Detection. Transplant Proc. 2018; 51: 350–352. doi: 10.1016/j.transproceed.2018.12.016.Sánchez DM, García LJ, Jiménez IL, Luján IS, Soriano MG, Viñas SL et al. Renal Function Impairment in Kidney Transplantation: Importance of Early BK Virus Detection. Transplant Proc. 2018; 51: 350–352. doi: 10.1016/j.transproceed.2018.12.016.Madden K, Janitell C, Sower D, Yang S. Prediction of BK viremia by urine viral load in renal transplant patients: An analysis of BK viral load results in paired urine and plasma samples. Transpl Infect Dis. 2018; 20: e12952. doi: 10.1111/tid.12952.Madden K, Janitell C, Sower D, Yang S. Prediction of BK viremia by urine viral load in renal transplant patients: An analysis of BK viral load results in paired urine and plasma samples. Transpl Infect Dis. 2018; 20: e12952. doi: 10.1111/tid.12952.Myint TM, Chong CHY, Wyld M, Nankivell B, Kable K, Wong G. Polyoma BK Virus in Kidney Transplant Recipients: Screening, Monitoring, and Management. Transplantation. 2022; 106 (1): e76–e89. doi: 10.1097/TP.0000000000003801.Myint TM, Chong CHY, Wyld M, Nankivell B, Kable K, Wong G. Polyoma BK Virus in Kidney Transplant Recipients: Screening, Monitoring, and Management. Transplantation. 2022; 106 (1): e76–e89. doi: 10.1097/TP.0000000000003801.Bicalho CS, Oliveira RDR, David DR, Fink MCDS, Agena F, Castro MC et al. Determination of viremia cutoff for risk to develop BKPyV-associated nephropathy among kidney transplant recipients. Transpl Infect Dis. 2018; 20: e12969. doi: 10.1111/tid.12969.Bicalho CS, Oliveira RDR, David DR, Fink MCDS, Agena F, Castro MC et al. Determination of viremia cutoff for risk to develop BKPyV-associated nephropathy among kidney transplant recipients. Transpl Infect Dis. 2018; 20: e12969. doi: 10.1111/tid.12969.Höcker B, Schneble L, Murer L, Carraro A, Pape L, Kranz B et al. Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study. Transplantation. 2019; 103: 1224–1233. doi: 10.1097/TP.0000000000002414.Höcker B, Schneble L, Murer L, Carraro A, Pape L, Kranz B et al. Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study. Transplantation. 2019; 103: 1224–1233. doi: 10.1097/TP.0000000000002414.Elfadawy N, Flechner SM. Retransplantation after nonadherence-related kidney allograft failure – forgive or forget? Transpl Int. 2019; 32 (12): 1241–1243. doi: 10.1111/tri.13531.Elfadawy N, Flechner SM. Retransplantation after nonadherence-related kidney allograft failure – forgive or forget? Transpl Int. 2019; 32 (12): 1241–1243. doi: 10.1111/tri.13531.Alcendor DJ. BK Polyomavirus Virus Glomerular Tropism: Implications for Virus Reactivation from Latency and Amplification during Immunosuppression. J Clin Med. 2019; 8 (9): 1477. doi: 10.3390/jcm8091477.Alcendor DJ. BK Polyomavirus Virus Glomerular Tropism: Implications for Virus Reactivation from Latency and Amplification during Immunosuppression. J Clin Med. 2019; 8 (9): 1477. doi: 10.3390/jcm8091477.Sirohi D, Vaske C, Sanborn Z, Smith SC, Don MD, Lindsey KG et al. Polyoma virus-associated carcinomas of the urologic tract: A clinicopathologic and molecular study. Mod Pathol. 2018; 31: 1429–1441. doi: 10.1038/s41379-018-0065-z.Sirohi D, Vaske C, Sanborn Z, Smith SC, Don MD, Lindsey KG et al. Polyoma virus-associated carcinomas of the urologic tract: A clinicopathologic and molecular study. Mod Pathol. 2018; 31: 1429–1441. doi: 10.1038/s41379-018-0065-z.Zhou X, Zhu C, Li H. BK polyomavirus: latency, reactivation, diseases and tumorigenesis. Front Cell Infect Microbiol. 2023; 13: 1263983. doi: 10.3389/fcimb.2023.1263983.Zhou X, Zhu C, Li H. BK polyomavirus: latency, reactivation, diseases and tumorigenesis. Front Cell Infect Microbiol. 2023; 13: 1263983. doi: 10.3389/fcimb.2023.1263983.Ahlenstiel-Grunow T, Pape L. Diagnostics, treatment, and immune response in BK polyomavirus infection after pediatric kidney transplantation. Pediatr Nephrol. 2020; 35 (3): 375–382. doi: 10.1007/s00467-018-4164- 3.Ahlenstiel-Grunow T, Pape L. Diagnostics, treatment, and immune response in BK polyomavirus infection after pediatric kidney transplantation. Pediatr Nephrol. 2020; 35 (3): 375–382. doi: 10.1007/s00467-018-4164- 3.Cho MH. Monitoring BK virus infection in pediatric kidney transplant recipients. Korean J Pediatr. 2019; 62 (11): 414–415. doi: 10.3345/kjp.2019.01123.Cho MH. Monitoring BK virus infection in pediatric kidney transplant recipients. Korean J Pediatr. 2019; 62 (11): 414–415. doi: 10.3345/kjp.2019.01123.Wong G, Myint TM, Lee YJ, Craig JC, Axelrod D, Kiberd B. Economic Evaluation of Screening for Polyomavirus Infection in Kidney Transplant Recipients: A CostUtility Analysis. Transplant Direct. 2022; 8 (5): e1318. doi: 10.1097/TXD.0000000000001318.Wong G, Myint TM, Lee YJ, Craig JC, Axelrod D, Kiberd B. Economic Evaluation of Screening for Polyomavirus Infection in Kidney Transplant Recipients: A CostUtility Analysis. Transplant Direct. 2022; 8 (5): e1318. doi: 10.1097/TXD.0000000000001318.Furmaga J, Kowalczyk M, Zapolski T, Furmaga O, Krakowski L, Rudzki G et al. BK Polyomavirus-Biology, Genomic Variation and Diagnosis. Viruses. 2021; 13 (8): 1502. doi: 10.3390/v13081502.Furmaga J, Kowalczyk M, Zapolski T, Furmaga O, Krakowski L, Rudzki G et al. BK Polyomavirus-Biology, Genomic Variation and Diagnosis. Viruses. 2021; 13 (8): 1502. doi: 10.3390/v13081502.Wang Y, Strassl R, Helanterä I, Aberle SW, Bond G, Hedman K et al. Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication. J Clin Virol. 2019; 120: 6–11. doi: 10.1016/j.jcv.2019.08.012.Wang Y, Strassl R, Helanterä I, Aberle SW, Bond G, Hedman K et al. Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication. J Clin Virol. 2019; 120: 6–11. doi: 10.1016/j.jcv.2019.08.012.Mineeva-Sangwo O, Martí-Carreras J, Cleenders E, Kuypers D, Maes P, Andrei G et al. Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation. Viruses. 2022; 14 (7): 1533. doi: 10.3390/v14071533.Mineeva-Sangwo O, Martí-Carreras J, Cleenders E, Kuypers D, Maes P, Andrei G et al. Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation. Viruses. 2022; 14 (7): 1533. doi: 10.3390/v14071533.Govind S, Hockley J, Morris C, Almond N. The development and establishment of the 1st WHO BKV International Standard for nucleic acid based techniques. Biologicals. 2019; 60: 75–84. doi: 10.1016/j.biologicals.2019.04.004.Govind S, Hockley J, Morris C, Almond N. The development and establishment of the 1st WHO BKV International Standard for nucleic acid based techniques. Biologicals. 2019; 60: 75–84. doi: 10.1016/j.biologicals.2019.04.004.Brochot E, Descamps V, Handala L, Faucher J, Choukroun G, Helle F et al. BK polyomavirus in the urine for follow-up of kidney transplant recipients. Clin Microbiol Infect. 2019; 25 (1): 112.e1–112.e5. doi: 10.1016/j.cmi.2018.07.027.Brochot E, Descamps V, Handala L, Faucher J, Choukroun G, Helle F et al. BK polyomavirus in the urine for follow-up of kidney transplant recipients. Clin Microbiol Infect. 2019; 25 (1): 112.e1–112.e5. doi: 10.1016/j.cmi.2018.07.027.Sekito T, Araki M, Yoshinaga K, Maruyama Y, Sadahira T, Nishimura S et al. Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients. Int J Urol. 2021; 28 (12): 1240–1246. doi: 10.1111/iju.14679.Sekito T, Araki M, Yoshinaga K, Maruyama Y, Sadahira T, Nishimura S et al. Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients. Int J Urol. 2021; 28 (12): 1240–1246. doi: 10.1111/iju.14679.D’Alessandro M, Poli L, Lai Q, Gaeta A, Nazzari C, Garofalo M et al. Automated Intelligent Microscopy for the Recognition of Decoy Cells in Urine Samples of Kidney Transplant Patients. Transplant Proc. 2019; 51 (1): 157–159. doi: 10.1016/j.transproceed.2018.05.030.D’Alessandro M, Poli L, Lai Q, Gaeta A, Nazzari C, Garofalo M et al. Automated Intelligent Microscopy for the Recognition of Decoy Cells in Urine Samples of Kidney Transplant Patients. Transplant Proc. 2019; 51 (1): 157–159. doi: 10.1016/j.transproceed.2018.05.030.Funahashi Y. Editorial Comment to Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients. Int J Urol. 2021; 28 (12): 1246. doi: 10.1111/iju.14699.Funahashi Y. Editorial Comment to Presence of decoy cells for 6 months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients. Int J Urol. 2021; 28 (12): 1246. doi: 10.1111/iju.14699.Procario MC, Sexton JZ, Halligan BS, Imperiale MJ. Single-Cell, High-Content Microscopy Analysis of BK Polyomavirus Infection. Microbiol Spectr. 2023; 11 (3): e0087323. doi: 10.1128/spectrum.00873-23.Procario MC, Sexton JZ, Halligan BS, Imperiale MJ. Single-Cell, High-Content Microscopy Analysis of BK Polyomavirus Infection. Microbiol Spectr. 2023; 11 (3): e0087323. doi: 10.1128/spectrum.00873-23.Nickeleit V, Davis VG, Thompson B, Singh HK. The Urinary Polyomavirus-Haufen Test: A Highly Predictive Non-Invasive Biomarker to Distinguish «Presumptive» from «Definitive» Polyomavirus Nephropathy: How to Use It-When to Use It-How Does It Compare to PCR Based Assays? Viruses. 2021; 13 (1): 135. doi: 10.3390/v13010135.Nickeleit V, Davis VG, Thompson B, Singh HK. The Urinary Polyomavirus-Haufen Test: A Highly Predictive Non-Invasive Biomarker to Distinguish «Presumptive» from «Definitive» Polyomavirus Nephropathy: How to Use It-When to Use It-How Does It Compare to PCR Based Assays? Viruses. 2021; 13 (1): 135. doi: 10.3390/v13010135.Kant S, Bromberg J, Haas M, Brennan D. Donor-derived Cell-free DNA and the Prediction of BK Virus-associated Nephropathy. Transplant Direct. 2020; 6: e622. doi: 10.1097/TXD.0000000000001061.Kant S, Bromberg J, Haas M, Brennan D. Donor-derived Cell-free DNA and the Prediction of BK Virus-associated Nephropathy. Transplant Direct. 2020; 6: e622. doi: 10.1097/TXD.0000000000001061.Kant S, Brennan DC. Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update. Transpl Int. 2022; 35: 115. doi: 10.3389/ti.2022.10448.Kant S, Brennan DC. Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020–2021 Update. Transpl Int. 2022; 35: 115. doi: 10.3389/ti.2022.10448.Kant S, Brennan D. Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future. Medicina. 2021; 57: 482. doi: 10.3390/medicina57050482.Kant S, Brennan D. Donor-Derived Cell-Free DNA in Kidney Transplantation: Origins, Present and a Look to the Future. Medicina. 2021; 57: 482. doi: 10.3390/medicina57050482.Nankivell BJ, Renthawa J, Shingde M, Khan A. The Importance of Kidney Medullary Tissue for the Accurate Diagnosis of BK Virus Allograft Nephropathy. Clin J Am Soc Nephrol. 2020; 15: 1015–1023. doi: 10.2215/CJN.13611119.Nankivell BJ, Renthawa J, Shingde M, Khan A. The Importance of Kidney Medullary Tissue for the Accurate Diagnosis of BK Virus Allograft Nephropathy. Clin J Am Soc Nephrol. 2020; 15: 1015–1023. doi: 10.2215/CJN.13611119.Nickeleit V, Singh HK, Randhawa P, Drachenberg CB, Bhatnagar R, Bracamonte E et al. The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations. J Am Soc Nephrol. 2018; 29: 680–693. doi: 10.1681/ASN.2017050477.Nickeleit V, Singh HK, Randhawa P, Drachenberg CB, Bhatnagar R, Bracamonte E et al. The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations. J Am Soc Nephrol. 2018; 29: 680–693. doi: 10.1681/ASN.2017050477.Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D et al. The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell – mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 2018; 18: 293–307. doi: 10.1111/ajt.14625.Haas M, Loupy A, Lefaucheur C, Roufosse C, Glotz D, Seron D et al. The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell – mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials. Am J Transplant. 2018; 18: 293–307. doi: 10.1111/ajt.14625.Yang D, Zhuang B, Wang Y, Huang G, Xu M, Lin M et al. High-Frequency US for BK Polyomavirus-associated Nephropathy after Kidney Transplant. Radiology. 2022; 304 (2): 333–341. doi: 10.1148/radiol.211855.Yang D, Zhuang B, Wang Y, Huang G, Xu M, Lin M et al. High-Frequency US for BK Polyomavirus-associated Nephropathy after Kidney Transplant. Radiology. 2022; 304 (2): 333–341. doi: 10.1148/radiol.211855.Costigliolo F, Lombardo K, Arend LJ, Rosenberg AZ, Matoso A, Carter-Monroe N et al. BK Virus RNA in Renal Allograft Biopsies. J Histochem Cytochem. 2020; 68 (5): 319–325. doi: 10.1369/0022155420922604.Costigliolo F, Lombardo K, Arend LJ, Rosenberg AZ, Matoso A, Carter-Monroe N et al. BK Virus RNA in Renal Allograft Biopsies. J Histochem Cytochem. 2020; 68 (5): 319–325. doi: 10.1369/0022155420922604.Nickeleit V, Singh HK, Dadhania D, Cornea V, El-Husseini A, Castellanos A et al. The 2018 Banff Working Group classification of definitive polyomavirus nephropathy: A multicenter validation study in the modern era. Am J Transplant. 2021; 21 (2): 669–680. doi: 10.1111/ajt.16189.Nickeleit V, Singh HK, Dadhania D, Cornea V, El-Husseini A, Castellanos A et al. The 2018 Banff Working Group classification of definitive polyomavirus nephropathy: A multicenter validation study in the modern era. Am J Transplant. 2021; 21 (2): 669–680. doi: 10.1111/ajt.16189.Kaur A, Wilhelm M, Wilk S, Hirsch HH. BK polyomavirus-specific antibody and T-cell responses in kidney transplantation: update. Curr Opin Infect Dis. 2019; 32 (6): 575–583. doi: 10.1097/QCO.0000000000000602.Kaur A, Wilhelm M, Wilk S, Hirsch HH. BK polyomavirus-specific antibody and T-cell responses in kidney transplantation: update. Curr Opin Infect Dis. 2019; 32 (6): 575–583. doi: 10.1097/QCO.0000000000000602.Cheungpasitporn W, Kremers WK, Lorenz E, Amer H, Cosio FG, Stegall MD et al. De Novo Donor-Specific Antibody Following BK Nephropathy: The Incidence and Association with Antibody-Mediated Rejection. Clin Transpl. 2018; 32: e13194. doi: 10.1111/ctr.13194.Cheungpasitporn W, Kremers WK, Lorenz E, Amer H, Cosio FG, Stegall MD et al. De Novo Donor-Specific Antibody Following BK Nephropathy: The Incidence and Association with Antibody-Mediated Rejection. Clin Transpl. 2018; 32: e13194. doi: 10.1111/ctr.13194.Sharma R, Zachariah M. BK Virus Nephropathy: Prevalence, Impact and Management Strategies. Int J Nephrol Renovasc Dis. 2020; 13: 187–192. doi: 10.2147/IJNRD.S236556.Sharma R, Zachariah M. BK Virus Nephropathy: Prevalence, Impact and Management Strategies. Int J Nephrol Renovasc Dis. 2020; 13: 187–192. doi: 10.2147/IJNRD.S236556.Matsumura S, Kato T, Taniguchi A, Kawamura M, Nakazawa S, Namba-Hamano T et al. Clinical Efficacy of Intravenous Immunoglobulin for BK Polyomavirus-Associated Nephropathy After Living Kidney Transplantation. Ther Clin Risk Manag. 2020; 16: 947–952. doi: 10.2147/TCRM.S273388.Matsumura S, Kato T, Taniguchi A, Kawamura M, Nakazawa S, Namba-Hamano T et al. Clinical Efficacy of Intravenous Immunoglobulin for BK Polyomavirus-Associated Nephropathy After Living Kidney Transplantation. Ther Clin Risk Manag. 2020; 16: 947–952. doi: 10.2147/TCRM.S273388.Velay A, Solis M, Benotmane I, Gantner P, Soulier E, Moulin B et al. Intravenous Immunoglobulin Administration Significantly Increases BKPyV Genotype-Specific Neutralizing Antibody Titers in Kidney Transplant Recipients. Antimicrob Agents Chemother. 2019; 63 (8): e00393-19. doi: 10.1128/AAC.00393-19.Velay A, Solis M, Benotmane I, Gantner P, Soulier E, Moulin B et al. Intravenous Immunoglobulin Administration Significantly Increases BKPyV Genotype-Specific Neutralizing Antibody Titers in Kidney Transplant Recipients. Antimicrob Agents Chemother. 2019; 63 (8): e00393-19. doi: 10.1128/AAC.00393-19.Rasaei N, Malekmakan L, Gholamabbas G, Abdizadeh P. Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial. Exp Clin Transplant. 2023; 21 (10): 814–819. doi: 10.6002/ect.2023.0071.Rasaei N, Malekmakan L, Gholamabbas G, Abdizadeh P. Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial. Exp Clin Transplant. 2023; 21 (10): 814–819. doi: 10.6002/ect.2023.0071.Benotmane I, Solis M, Velay A, Cognard N, Olagne J, Vargas GG et al. Intravenous immunoglobulin as a preventive strategy against BK virus viremia and BKVassociated nephropathy in kidney transplant recipients – Results from a proof-of-concept study. Am J Transplant. 2021; 21: 329–337. doi: 10.1111/ajt.16233.Benotmane I, Solis M, Velay A, Cognard N, Olagne J, Vargas GG et al. Intravenous immunoglobulin as a preventive strategy against BK virus viremia and BKVassociated nephropathy in kidney transplant recipients – Results from a proof-of-concept study. Am J Transplant. 2021; 21: 329–337. doi: 10.1111/ajt.16233.Mohammad D, Kim DY, Baracco R, Kapur G, Jain A. Treatment of BK virus with a stepwise immunosuppression reduction and intravenous immunoglobulin in pediatric kidney transplant. Pediatr Transplant. 2022; 26 (4): e14241. doi: 10.1111/petr.14241.Mohammad D, Kim DY, Baracco R, Kapur G, Jain A. Treatment of BK virus with a stepwise immunosuppression reduction and intravenous immunoglobulin in pediatric kidney transplant. Pediatr Transplant. 2022; 26 (4): e14241. doi: 10.1111/petr.14241.Patel SJ, Knight RJ, Kuten SA, Graviss EA, Nguyen DT, Moore LW et al. Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: Results of a prospective, double-blind, randomized, placebo-controlled trial. Am J Transplant. 2019; 19: 1831–1837. doi: 10.1111/ajt.15328.Patel SJ, Knight RJ, Kuten SA, Graviss EA, Nguyen DT, Moore LW et al. Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: Results of a prospective, double-blind, randomized, placebo-controlled trial. Am J Transplant. 2019; 19: 1831–1837. doi: 10.1111/ajt.15328.Mühlbacher T, Beck R, Nadalin S, Heyne N, Guthoff M. Low-dose cidofovir and conversion to mTOR-based immunosuppression in polyomavirus-associated nephropathy. Transpl Infect Dis. 2020; 22 (2): e13228. doi: 10.1111/tid.13228.Mühlbacher T, Beck R, Nadalin S, Heyne N, Guthoff M. Low-dose cidofovir and conversion to mTOR-based immunosuppression in polyomavirus-associated nephropathy. Transpl Infect Dis. 2020; 22 (2): e13228. doi: 10.1111/tid.13228.Velioglu A, Erdogan E, Tigen E, Ozgen Z, Tuglular S. Topical cidofovir-related acute kidney injury in a kidney transplant recipient. Clin Transplant. 2022; 36 (11): e14824. doi: 10.1111/ctr.14824.Velioglu A, Erdogan E, Tigen E, Ozgen Z, Tuglular S. Topical cidofovir-related acute kidney injury in a kidney transplant recipient. Clin Transplant. 2022; 36 (11): e14824. doi: 10.1111/ctr.14824.Yamazaki T, Shirai H, Tojimbara T. Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series. Am J Case Rep. 2020; 21: e927367. doi: 10.12659/AJCR.927367.Yamazaki T, Shirai H, Tojimbara T. Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series. Am J Case Rep. 2020; 21: e927367. doi: 10.12659/AJCR.927367.Schneidewind L, Neumann T, Dräger DL, Kranz J, Hakenberg OW. Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients – A systematic review. Transplant Rev (Orlando). 2020; 34 (4): 100565. doi: 10.1016/j.trre.2020.100565.Schneidewind L, Neumann T, Dräger DL, Kranz J, Hakenberg OW. Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients – A systematic review. Transplant Rev (Orlando). 2020; 34 (4): 100565. doi: 10.1016/j.trre.2020.100565.Chen SY, Teng RH, Wang M, Chen PL, Lin MC, Shen CH et al. Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells. Evid Based Complement Alternat Med. 2017; 2017: 5620867. doi: 10.1155/2017/5620867.Chen SY, Teng RH, Wang M, Chen PL, Lin MC, Shen CH et al. Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells. Evid Based Complement Alternat Med. 2017; 2017: 5620867. doi: 10.1155/2017/5620867.Leeaphorn N, Thongprayoon C, Chon WJ, Cummings LS, Mao MA, Cheungpasitporn W. Outcomes of kidney retransplantation after graft loss as a result of BK virus nephropathy in the era of newer immunosuppressant agents. Am J Transplant. 2019; 20: 1334–1340. doi: 10.1111/ajt.15723.Leeaphorn N, Thongprayoon C, Chon WJ, Cummings LS, Mao MA, Cheungpasitporn W. Outcomes of kidney retransplantation after graft loss as a result of BK virus nephropathy in the era of newer immunosuppressant agents. Am J Transplant. 2019; 20: 1334–1340. doi: 10.1111/ajt.15723.Nguyen K, Diamond A, Carlo AD, Karhadkar S. Characterization of Kidney Retransplantation Following Graft Failure Due to BK Virus Nephropathy. J Surg Res. 2022; 269: 110–118. doi: 10.1016/j.jss.2021.07.047.Nguyen K, Diamond A, Carlo AD, Karhadkar S. Characterization of Kidney Retransplantation Following Graft Failure Due to BK Virus Nephropathy. J Surg Res. 2022; 269: 110–118. doi: 10.1016/j.jss.2021.07.047.

The authors declare that there are no conflicts of interest present.