References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2012-2-86-97

vtio-168

Research Article

Обзор литературы

Literature Reviews

БАЛАНС ВЗАИМОДЕЙСТВИЯ ЭФФЕКТОРНЫХ И РЕГУЛЯТОРНЫХ КЛЕТОК ПАМЯТИ КАК ОСНОВА ВЫРАБОТКИ УСТОЙЧИВОЙ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ПЕРЕСАДКЕ ОРГАНОВ (АНАЛИЗ ПРОБЛЕМЫ НА ПРИМЕРЕ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ)

THE BALANCE OF EFFECTORY AND REGULATORY MEMORY CELL INTERACTIONS AS A BASE FOR PRODUCING OF STEADY IMMUNE TOLERANCE STATE AFTER ORGAN TRANSPLANTATION (ANALYSIS OF PROBLEM AT THE LIVER TRANSPLANTATION EXAMPLE)

Артамонов

С. Д.

Artamonov

S. D.

Великий

Д. А.

Velikiy

D. A.

Онищенко

Н. А.

Onischenko

N. A.

Башкина

Л. В.

Bashkina

L. V.

Никольская

А. О.

Nikolskaya

A. O.

Крашенинников

М. Е.

Krasheninnikov

M. E.

Иванов

И. М.

Ivanov

I. M.

ФГБУ «ФНЦ трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздравсоцразвития России, г. МоскваAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow

2012

28052014

142

ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XIV No 2–2012

8697

2012

Артамонов С.Д., Великий Д.А., Онищенко Н.А., Башкина Л.В., Никольская А.О., Крашенинников М.Е., Иванов И.М.

Artamonov S.D., Velikiy D.A., Onischenko N.A., Bashkina L.V., Nikolskaya A.O., Krasheninnikov M.E., Ivanov I.M.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/168

В статье представлен анализ механизмов и способов выработки иммунной толерантности в организме при воздействии антигенных нагрузок различной природы. Показано, что состояние устойчивой толерантности достигается путем воссоздания баланса взаимодей- ствия эффекторных и регуляторных клеток во врожденной и адаптивной иммунной системе. Однако из- за высокого риска отторжения трансплантата при разных способах выработки толерантности возникает необходимость разработки надежных диагностических и прогностических методов контроля уровня и степени индивидуальной устойчивости толерантности.

In this article the main mechanisms and methods of immune tolerance producing under influence of different antigenic loads in organism were considered. It was shown that the state of steady tolerance was produced by making the balance of effectory and regulatory cell interactions into innate and adaptive immunities. But because of a high risk of transplant rejection at different methods of tolerance producing it is necessary to work out safe diagnostic and prognostic methods for controlling of an individual level and power tolerance stability.

острое и хроническое отторжениеиммунная толерантностьаллотрансплантация

acute and chronic rejectionimmune toleranceallotransplantation

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The authors declare that there are no conflicts of interest present.