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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2023-4-22-31</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1677</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая трансплантология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Transplantology</subject></subj-group></article-categories><title-group><article-title>Лечение сосудистых осложнений  после ортотопической трансплантации печени.  Опыт регионального центра</article-title><trans-title-group xml:lang="en"><trans-title>Treatment of vascular complications following  orthotopic liver transplantation. The experience  of a regional cente</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коробка</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Korobka</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">rokb@aaanet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кострыкин</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostrykin</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кострыкин Михаил Юрьевич</p><p>344015, Ростов-на-Дону, Благодатная ул., д. 170</p><p>Тел. (918) 554-16-28</p></bio><bio xml:lang="en"><p>Michael Kostrykin</p><p>170, Blagodatnaya str., Rostov-on-Don, 344015</p><p>Phone: (918) 554-16-28</p></bio><email xlink:type="simple">michael_cs@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малеванный</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Malevanny</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">rokb@aaanet.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котов</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">angiolegkotov@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коробка</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korobka</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">rokb@aaanet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пак</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pak</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">rokb@aaanet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хоронько</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khoronko</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">okt@rostgmu.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сапронова</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sapronova</surname><given-names>N.  G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">okt@rostgmu.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суханов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhanov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">rokb@aaanet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хоронько</surname><given-names>Р. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Khoronko</surname><given-names>R. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">rokb@aaanet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ РО "Ростовская областная клиническая больница"; ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Regional Clinical Hospital; Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУ РО "Ростовская областная клиническая больница"</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>11</month><year>2023</year></pub-date><volume>25</volume><issue>4</issue><fpage>22</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коробка В.Л., Кострыкин М.Ю., Малеванный М.В., Котов О.В., Коробка Р.В., Пак Е.С., Хоронько Ю.В., Сапронова Н.Г., Суханов И.А., Хоронько Р.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Коробка В.Л., Кострыкин М.Ю., Малеванный М.В., Котов О.В., Коробка Р.В., Пак Е.С., Хоронько Ю.В., Сапронова Н.Г., Суханов И.А., Хоронько Р.Ю.</copyright-holder><copyright-holder xml:lang="en">Korobka V.L., Kostrykin M.Y., Malevanny M.V., Kotov O.V., Korobka R.V., Pak E.S., Khoronko Y.V., Sapronova N.G., Sukhanov I.A., Khoronko R.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1677">https://journal.transpl.ru/vtio/article/view/1677</self-uri><abstract><sec><title>Цели</title><p>Цели: сосудистые осложнения после трансплантации печени могут представлять существенную угрозу жизни реципиента, так как при нарушении кровотока в трансплантате значительно увеличивается риск потери донорской печени. Диагностика и своевременное лечение сосудистых осложнений представляется актуальной проблемой трансплантологии. Целью этого исследования была оценка заболеваемости, лечения и исхода сосудистых осложнений пациентов после ортотопической трансплантации печени в центре хирургии и координации донорства Ростовской областной клинической больницы.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В период с июля 2015 года по апрель 2023 года было выполнено 100 ортотопических трансплантаций печени. Ретро спективно идентифицированы и проанализированы сосудистые осложнения у реципиентов.</p></sec><sec><title>Результаты</title><p>Результаты. Общая частота возникновения сосудистых осложнений составила 24% (n = 24), из них: стеноз печеночной артерии – 5% (n = 5), внутрибрюшные кровотечения – 6% (n = 6), диссекции стенки ПА – 2% (n = 2), внутрипеченочные венозные тромбозы (синдром Бадда–Киари) – 2% (n = 2), тромбоз воротной вены 1% (n = 1), тромбоз нижней полой вены/илеофеморальный венозный тромбоз – 2% (n = 2), стеноз нижней полой вены – 1% (n = 1), стеноз печеночной вены – 1% (n = 1), повторный стеноз/тромбоз ПА – 2% (n = 2), тромбоз брыжеечных вен – 2% (n = 2).</p></sec><sec><title>Вывод</title><p>Вывод. Большинство сосудистых осложнений после ортотопиче ской трансплантации печени возникают в раннем послеоперационном периоде и могут привести к высокому риску дисфункции трансплантата и смерти пациента. Раннее распознавание, диагностика и лечение осложнений после ортотопической трансплантации печени имеют решающее значение для успешного краткосрочного и долгосрочного функционирования трансплантата и выживаемости пациентов, даже у пациентов с бессимптомным течением осложнения. Варианты лечения обычно включают хирургическую реваскуляризацию, чрескожный тромболизис, чрескожную ангиопластику, ретрансплантацию или реже консервативный подход.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: vascular complications (VCs) following liver transplantation (LT) can pose a significant threat to the recipient’s life – as the risk of graft loss increases significantly when blood flow in the graft is impaired. Diagnosis and early treatment of VCs seems to be a pressing issue in transplantology. The aim of this study is to evaluate the incidence, treatment and outcome of VCs in patients after orthotopic LT at the Center for Surgery and Donor Coordination, Rostov Regional Clinical Hospital.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Between July 2015 and April 2023, 100 orthotopic LTs were performed. VCs were retrospectively identified and analyzed.</p></sec><sec><title>Results</title><p>Results. The overall incidence of VCs was 24% (n = 24): hepatic artery stenosis, 5% (n = 5); intra-abdominal bleeding, 6% (n = 6); hepatic artery dissection, 2% (n = 2); intrahepatic venous thrombosis Budd–Chiari syndrome), 2% (n = 2); portal vein thrombosis, 1% (n = 1); inferior vena cava thrombosis/iliofemoral deep vein thrombosis, 2% (n = 2); inferior vena cava stenosis, 1% (n = 1); hepatic vein stenosis, 1% (n = 1); recurrent hepatic artery stenosis/thrombosis, 2% (n = 2); mesenteric vein thrombosis, 2% (n = 2).</p></sec><sec><title>Conclusion</title><p>Conclusion. Most VCs following orthotopic LT occur in the early postoperative period and can lead to a high risk of graft dysfunction and patient death. Early recognition, diagnosis, and treatment of post-LT complications are critical to successful short- and long-term graft function and patient survival, even in patients with asymptomatic complications. Treatment options typically include surgical revascularization, percutaneous thrombolysis, percutaneous angioplasty, retransplantation, or, less commonly, a conservative approach.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация печени</kwd><kwd>сосудистые осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver transplantation</kwd><kwd>vascular complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Stange BJ, Glanemann M, Nuessler NC, Settmacher U, Steinmüller T, Neuhaus P. Hepatic artery thrombosis after adult liver transplantation. Liver Transpl. 2003 Jun; 9 (6): 612–620. Текст: электронный. 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