vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2023-3-31-37vtio-1673Research ArticleКлиническая трансплантологияClinical TransplantologyИспользование криотехнологий в трансплантации легких и сердечно-легочного комплексаCryotechnology in lung and heart-lung transplantationБековМ. Т.BekovM. T.

Беков Максат Турдумаматович,

123182, Москва, ул. Щукинская, д. 1

Moscow

doctorbekov@gmail.comПашковИ. В.PashkovI. V.

Москва

Moscow

МожейкоН. П.MozheikoN. P.

Москва

Moscow

ЛатыповР. А.LatypovR. A.

Москва

Moscow

ОлешкевичД. О.OleshkevichD. O.

Москва

Moscow

СмирновК. С.SmirnovK. S.

Москва

Moscow

ШигаевЕ. Ф.ShigaevE. F.

Москва

Moscow

ЯкунинЯ. С.YakuninYa. S.

Москва

Moscow

ГотьеС. В.GautierS. V.

Москва

Moscow

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityRussian Federation2023200720232533137Copyright © Беков М.Т., Пашков И.В., Можейко Н.П., Латыпов Р.А., Олешкевич Д.О., Смирнов К.С., Шигаев Е.Ф., Якунин Я.С., Готье С.В., 20232023Беков М.Т., Пашков И.В., Можейко Н.П., Латыпов Р.А., Олешкевич Д.О., Смирнов К.С., Шигаев Е.Ф., Якунин Я.С., Готье С.В.Bekov M.T., Pashkov I.V., Mozheiko N.P., Latypov R.A., Oleshkevich D.O., Smirnov K.S., Shigaev E.F., Yakunin Y.S., Gautier S.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1673

Бронхиальные осложнения наряду с развитием и прогрессированием хронической дисфункции на фоне хронического отторжения являются факторами, снижающими качество и продолжительность жизни реципиентов легких и сердечно-легочного комплекса, а также увеличивающими частоту госпитализаций. В основе применения криотехнологий лежит контактное воздействие чрезвычайно низких температур на органы и ткани с помощью криозонда. В данной статье демонстрируется опыт применения криотехнологий в диагностике и лечении осложнений у реципиентов легких и сердечно-легочного комплекса.

Bronchial complications, along with development and progression of chronic dysfunction on the background of chronic rejection, are factors that reduce the quality and life of lung and heart-lung recipients. They also increase the frequency of hospitalizations. Application of cryotechnology is based on the contact effect of extremely low temperatures on organs and tissues using a cryoprobe. This article demonstrates the experience of using cryotechnology in the diagnosis and treatment of complications in lung and heart-lung recipients.

трансплантация легкихтрансплантация сердечно-легочного комплексабронхиальные осложнениякриотехнологиикриоабляциякриобиопсиякриоадгезияэкстракция инородных тел из дыхательных путейlung transplantationheart-lung transplantationbronchial complicationscryotechnologycryoablationcryobiopsycryoadhesionextraction of airway foreign bodiesReferences10 ведущих причин смерти в мире. Всемирная организация здравоохранения: официальный сайт. https://www.who.int/ru/news-room/fact-sheets/detail/the-top10-causes-of-death.10 vedushchikh prichin smerti v mire. Vsemirnaya organizatsiya zdravookhraneniya: ofitsial’nyy sayt. https://www.who.int/ru/news-room/fact-sheets/detail/the-top10-causes-of-death.Трансплантология и искусственные органы / Под ред. С.В. Готье. М.: Лаборатория знаний, 2018; 319.Transplantologiya i iskusstvennye organy / Pod red. S.V. Gautier. M.: Laboratoriya znaniy, 2018; 319.Hardy JD, Webb WR, Dalton MR jr and Walker GR. Lung Homotransplantation in Man: Report of the Initial Case. JAMA. 1963 Dec 21; 186: 1065–1074. doi: 10.1001/jama.1963.63710120001010.Hardy JD, Webb WR, Dalton MR jr and Walker GR. Lung Homotransplantation in Man: Report of the Initial Case. JAMA. 1963 Dec 21; 186: 1065–1074. doi: 10.1001/jama.1963.63710120001010.Awori Hayanga JW, Aboagye JK, Shigemura N, Hayanga HK, Murphy E, Khaghani A, D’Cunha J. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant. 2016 Oct; 35 (10): 1206–1211. doi: 10.1016/j.healun.2016.04.019.Awori Hayanga JW, Aboagye JK, Shigemura N, Hayanga HK, Murphy E, Khaghani A, D’Cunha J. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant. 2016 Oct; 35 (10): 1206–1211. doi: 10.1016/j.healun.2016.04.019.Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis. Proc Am Thorac Soc. 2009 Jan 15; 6 (1): 79–93. doi: 10.1513/pats.200808-094GO.Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis. Proc Am Thorac Soc. 2009 Jan 15; 6 (1): 79–93. doi: 10.1513/pats.200808-094GO.Machuzak M, Santacruz JF, Gildea T, Murthy SC. Airway complications after lung transplantation. Thorac Surg Clin. 2015; 25 (1): 55–75. doi: 10.1016/j.thorsurg.2014.09.008.Machuzak M, Santacruz JF, Gildea T, Murthy SC. Airway complications after lung transplantation. Thorac Surg Clin. 2015; 25 (1): 55–75. doi: 10.1016/j.thorsurg.2014.09.008.Khush KK, Cherikh WS, Chambers DC, Harhay MO, Hayes D Jr, Hsich E et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report – 2019; focus theme: Donor and recipient size match. J Heart Lung Transplant. 2019 Oct; 38 (10): 1056–1066. doi: 10.1016/j.healun.2019.08.004.Khush KK, Cherikh WS, Chambers DC, Harhay MO, Hayes D Jr, Hsich E et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report – 2019; focus theme: Donor and recipient size match. J Heart Lung Transplant. 2019 Oct; 38 (10): 1056–1066. doi: 10.1016/j.healun.2019.08.004.Noppen M, Meysman M, Van Herreweghe R, Lamote J, D’Haese J, Vincken W. Bronchoscopic cryotherapy: preliminary experience. Acta Clin Belg. 2001 Mar-Apr; 56 (2): 73–77. doi: 10.1179/acb.2001.013.Noppen M, Meysman M, Van Herreweghe R, Lamote J, D’Haese J, Vincken W. Bronchoscopic cryotherapy: preliminary experience. Acta Clin Belg. 2001 Mar-Apr; 56 (2): 73–77. doi: 10.1179/acb.2001.013.Homasson JP et al. Cryotherapy in chest medicine. Springer Science & Business Media, 2012.Homasson JP et al. Cryotherapy in chest medicine. Springer Science & Business Media, 2012.Colt HG. Bronchoscopic cryotechniques in adults. Uptodate, review. 2017. https://www.medilib.ir/uptodate/show/4407.Colt HG. Bronchoscopic cryotechniques in adults. Uptodate, review. 2017. https://www.medilib.ir/uptodate/show/4407.Herth FJ, Mayer M, Thiboutot J, Kapp CM, Sun J, Zhang X et al. Safety and Performance of Transbronchial Cryobiopsy for Parenchymal Lung Lesions. Chest. 2021 Oct; 160 (4): 1512–1519. doi: 10.1016/j.chest.2021.04.063.Herth FJ, Mayer M, Thiboutot J, Kapp CM, Sun J, Zhang X et al. Safety and Performance of Transbronchial Cryobiopsy for Parenchymal Lung Lesions. Chest. 2021 Oct; 160 (4): 1512–1519. doi: 10.1016/j.chest.2021.04.063.Schumann C, Hetzel J, Babiak AJ, Merk T, Wibmer T, Möller P et al. Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions. J Thorac Cardiovasc Surg. 2010 Aug; 140 (2): 417–421. doi: 10.1016/j.jtcvs.2009.12.028.Schumann C, Hetzel J, Babiak AJ, Merk T, Wibmer T, Möller P et al. Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions. J Thorac Cardiovasc Surg. 2010 Aug; 140 (2): 417–421. doi: 10.1016/j.jtcvs.2009.12.028.Ussavarungsi K, Kern RM, Roden AC, Ryu JH, Edell ES. Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease: Retrospective Analysis of 74 Cases. Chest. 2017 Feb; 151 (2): 400–408. doi: 10.1016/j.chest.2016.09.002.Ussavarungsi K, Kern RM, Roden AC, Ryu JH, Edell ES. Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease: Retrospective Analysis of 74 Cases. Chest. 2017 Feb; 151 (2): 400–408. doi: 10.1016/j.chest.2016.09.002.Bango-Álvarez A, Ariza-Prota M, Torres-Rivas H, Fernández-Fernández L, Prieto A, Sánchez I et al. Transbronchial cryobiopsy in interstitial lung disease: experience in 106 cases - how to do it. ERJ Open Res. 2017 Mar 22; 3 (1): 00148-2016. doi: 10.1183/23120541.00148-2016.Bango-Álvarez A, Ariza-Prota M, Torres-Rivas H, Fernández-Fernández L, Prieto A, Sánchez I et al. Transbronchial cryobiopsy in interstitial lung disease: experience in 106 cases - how to do it. ERJ Open Res. 2017 Mar 22; 3 (1): 00148-2016. doi: 10.1183/23120541.00148-2016.Mohanka M, Banga A. Alterations in Pulmonary Physiology with Lung Transplantation. Compr Physiol. 2023 Jan 30; 13 (1): 4269–4293. doi: 10.1002/cphy.c220008.Mohanka M, Banga A. Alterations in Pulmonary Physiology with Lung Transplantation. Compr Physiol. 2023 Jan 30; 13 (1): 4269–4293. doi: 10.1002/cphy.c220008.Lequia L et al. Post-transplant bronchial stenosis: A single center retrospective study Chest. 2022; 162 (4): A2582–A2583.Lequia L et al. Post-transplant bronchial stenosis: A single center retrospective study Chest. 2022; 162 (4): A2582–A2583.Kim HH, Jo KW, Shim TS, Ji W, Ahn JH, Oh DK et al. Incidence, risk factors, and clinical characteristics of airway complications after lung transplantation. Sci Rep. 2023 Jan 12; 13 (1): 667. doi: 10.1038/s41598-023-27864-1.Kim HH, Jo KW, Shim TS, Ji W, Ahn JH, Oh DK et al. Incidence, risk factors, and clinical characteristics of airway complications after lung transplantation. Sci Rep. 2023 Jan 12; 13 (1): 667. doi: 10.1038/s41598-023-27864-1.Delbove A, Senage T, Gazengel P, Tissot A, Lacoste P, Cellerin L et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis. 2022 Jan-Dec; 16: 17534666221110354. doi: 10.1177/17534666221110354.Delbove A, Senage T, Gazengel P, Tissot A, Lacoste P, Cellerin L et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis. 2022 Jan-Dec; 16: 17534666221110354. doi: 10.1177/17534666221110354.Santillana EC et al. A Case Report of Progressive Segmental Stenosis in a Transplant Patient. C44. Case Reports: Pulmonary Potpourri. Am Thor Soc. 2022: A4218– A4218.Santillana EC et al. A Case Report of Progressive Segmental Stenosis in a Transplant Patient. C44. Case Reports: Pulmonary Potpourri. Am Thor Soc. 2022: A4218– A4218.Marulli G, Loy M, Rizzardi G, Calabrese F, Feltracco P, Sartori F, Rea F. Surgical treatment of posttransplant bronchial stenoses: case reports. Transplant Proc. 2007 Jul-Aug; 39 (6): 1973–1975. doi: 10.1016/j.transproceed.2007.05.021.Marulli G, Loy M, Rizzardi G, Calabrese F, Feltracco P, Sartori F, Rea F. Surgical treatment of posttransplant bronchial stenoses: case reports. Transplant Proc. 2007 Jul-Aug; 39 (6): 1973–1975. doi: 10.1016/j.transproceed.2007.05.021.Puchalski J, Lee HJ, Sterman DH. Airway complications following lung transplantation. Clin Chest Med. 2011 Jun; 32 (2): 357–366. doi: 10.1016/j.ccm.2011.03.001.Puchalski J, Lee HJ, Sterman DH. Airway complications following lung transplantation. Clin Chest Med. 2011 Jun; 32 (2): 357–366. doi: 10.1016/j.ccm.2011.03.001.Gage AA, Guest K, Montes M, Caruana JA, Whalen DA Jr. Effect of varying freezing and thawing rates in experimental cryosurgery. Cryobiology. 1985 Apr; 22 (2): 175–182. doi: 10.1016/0011-2240(85)90172-5.Gage AA, Guest K, Montes M, Caruana JA, Whalen DA Jr. Effect of varying freezing and thawing rates in experimental cryosurgery. Cryobiology. 1985 Apr; 22 (2): 175–182. doi: 10.1016/0011-2240(85)90172-5.Smith JJ, Fraser J. An estimation of tissue damage and thermal history in the cryolesion. Cryobiology. 1974 Apr; 11 (2): 139–147. doi: 10.1016/0011-2240(74)90303-4.Smith JJ, Fraser J. An estimation of tissue damage and thermal history in the cryolesion. Cryobiology. 1974 Apr; 11 (2): 139–147. doi: 10.1016/0011-2240(74)90303-4.Miller RH, Mazur P. Survival of frozen-thawed human red cells as a function of cooling and warming velocities. Cryobiology. 1976 Aug; 13 (4): 404–414. doi: 10.1016/0011-2240(76)90096-1.Miller RH, Mazur P. Survival of frozen-thawed human red cells as a function of cooling and warming velocities. Cryobiology. 1976 Aug; 13 (4): 404–414. doi: 10.1016/0011-2240(76)90096-1.Русаков МА. Эндоскопическая криохирургия трахеи и бронхов (экспериментально-клиническое исследование): автореф. дис. … канд. мед. наук. М., 1983: 18.Rusakov MA. Endoskopicheskaya kriokhirurgiya trakhei i bronkhov (eksperimental’no-klinicheskoe issledovanie): avtoref. dis. … kand. med. nauk. M., 1983: 18.Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Respir J. 2006 Jul; 28 (1): 200–218. doi: 10.1183/09031936.06.00014006.Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Respir J. 2006 Jul; 28 (1): 200–218. doi: 10.1183/09031936.06.00014006.Maiwand MO, Zehr KJ, Dyke CM, Peralta M, Tadjkarimi S, Khagani A, Yacoub MH. The role of cryotherapy for airway complications after lung and heart-lung transplantation. Eur J Cardiothorac Surg. 1997 Oct; 12 (4): 549–554. doi: 10.1016/s1010-7940(97)00208-x.Maiwand MO, Zehr KJ, Dyke CM, Peralta M, Tadjkarimi S, Khagani A, Yacoub MH. The role of cryotherapy for airway complications after lung and heart-lung transplantation. Eur J Cardiothorac Surg. 1997 Oct; 12 (4): 549–554. doi: 10.1016/s1010-7940(97)00208-x.Rafanan AL, Mehta AC. Adult airway foreign body removal. What’s new? Clin Chest Med. 2001 Jun; 22 (2): 319–330. doi: 10.1016/s0272-5231(05)70046-0.Rafanan AL, Mehta AC. Adult airway foreign body removal. What’s new? Clin Chest Med. 2001 Jun; 22 (2): 319–330. doi: 10.1016/s0272-5231(05)70046-0.De Weerdt S, Noppen M, Remels L, Vanherreweghe R, Meysman M, Vincken W. Successful removal of a massive endobronchial blood clot by means of cryotherapy. J Bronchol Int Pulmonol. 2005; 12 (1): 23–24.De Weerdt S, Noppen M, Remels L, Vanherreweghe R, Meysman M, Vincken W. Successful removal of a massive endobronchial blood clot by means of cryotherapy. J Bronchol Int Pulmonol. 2005; 12 (1): 23–24.Hewlett JC, Rickman OB, Lentz RJ, Prakash UB, Maldonado F. Foreign body aspiration in adult airways: therapeutic approach. J Thorac Dis. 2017 Sep; 9 (9): 3398– 3409. doi: 10.21037/jtd.2017.06.137.Hewlett JC, Rickman OB, Lentz RJ, Prakash UB, Maldonado F. Foreign body aspiration in adult airways: therapeutic approach. J Thorac Dis. 2017 Sep; 9 (9): 3398– 3409. doi: 10.21037/jtd.2017.06.137.Fruchter O, Fridel L, Rosengarten D, Raviv Y, Rosanov V, Kramer MR. Transbronchial cryo-biopsy in lung transplantation patients: first report. Respirology. 2013 May; 18 (4): 669–673. doi: 10.1111/resp.12037.Fruchter O, Fridel L, Rosengarten D, Raviv Y, Rosanov V, Kramer MR. Transbronchial cryo-biopsy in lung transplantation patients: first report. Respirology. 2013 May; 18 (4): 669–673. doi: 10.1111/resp.12037.Tong R, Zhao L, Guo LJ, Zhou GW, Liang CY, Hou G et al. Application of transbronchial cryobiopsy in the diagnosis of postoperative complications after lung transplantation: a report of 6 cases. Chin J Tub Resp Dis. 2023 Jan 12; 46 (1): 34–39. doi: 10.3760/cma.j.cn112147-20220411-00301.Tong R, Zhao L, Guo LJ, Zhou GW, Liang CY, Hou G et al. Application of transbronchial cryobiopsy in the diagnosis of postoperative complications after lung transplantation: a report of 6 cases. Chin J Tub Resp Dis. 2023 Jan 12; 46 (1): 34–39. doi: 10.3760/cma.j.cn112147-20220411-00301.Mahajan AK, Folch E, Khandhar SJ, Channick CL, Santacruz JF, Mehta AC, Nathan SD. The Diagnosis and Management of Airway Complications Following Lung Transplantation. Chest. 2017 Sep; 152 (3): 627–638. doi: 10.1016/j.chest.2017.02.021.Mahajan AK, Folch E, Khandhar SJ, Channick CL, Santacruz JF, Mehta AC, Nathan SD. The Diagnosis and Management of Airway Complications Following Lung Transplantation. Chest. 2017 Sep; 152 (3): 627–638. doi: 10.1016/j.chest.2017.02.021.Mathur PN, Wolf KM, Busk MF, Briete WM, Datzman M. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996 Sep; 110 (3): 718–723. doi: 10.1378/chest.110.3.718.Mathur PN, Wolf KM, Busk MF, Briete WM, Datzman M. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996 Sep; 110 (3): 718–723. doi: 10.1378/chest.110.3.718.

The authors declare that there are no conflicts of interest present.