vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2024-1-26-35vtio-1652Research ArticleКлиническая трансплантологияClinical TransplantologyЛечение ишемической болезни сердца у пациентов с терминальной почечной недостаточностью на заместительной почечной терапииTreatment of ischemic heart disease in end-stage kidney disease patients on renal replacement therapyСеменоваЮ. В.SemenovaYu. V.

123182, Москва, ул. Щукинская, д. 1

1, Shchukinskaya str., Moscow, 123182

julie11.89@mail.ruМиронковБ. Л.MironkovB. L.

123182, Москва, ул. Щукинская, д. 1

1, Shchukinskaya str., Moscow, 123182

ПозЯ. Л.PozYa. L.

123182, Москва, ул. Щукинская, д. 1

1, Shchukinskaya str., Moscow, 123182

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian Federation2024131120232612635Copyright © Семенова Ю.В., Миронков Б.Л., Поз Я.Л., 20242024Семенова Ю.В., Миронков Б.Л., Поз Я.Л.Semenova Y.V., Mironkov B.L., Poz Y.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1652

Данная обзорная работа нацелена на анализ проблемы диагностики и лечения ишемической болезни сердца (ИБС) у пациентов с терминальной почечной недостаточностью (ТПН) на основании современных литературных данных. Рассматриваются вопросы стратификации риска ИБС перед включением пациентов в лист ожидания на трансплантацию почки и возможные сложности диагностики ИБС с помощью неинвазивных методов обследования у пациентов с ТПН. Проводится сравнение эффективности реваскуляризации миокарда и медикаментозной терапии, эндоваскулярной и хирургической реваскуляризации миокарда, а также рассматриваются особенности медикаментозной, в частности антиагрегантной и антигиперлипидемической, терапии в рамках лечения ИБС у диализ-зависимых пациентов и реципиентов почки.

This review paper aims to analyze the problem of diagnosis and treatment of coronary heart disease (CHD), also called ischemic heart disease (IHD), in patients with end-stage renal disease (ESRD). The analysis is based on current literature data. The issues of CHD risk stratification before patient listing for kidney transplantation (KT) and possible difficulties of diagnosing CHD using non-invasive examination methods in ESRD patients are considered. The effectiveness of myocardial revascularization and drug therapy, endovascular and surgical myocardial revascularization, is compared. The paper also discusses the peculiarities of drug therapy, particularly antiplatelet and antihyperlipidemic therapy in the treatment of CHD in dialysis-dependent patients and kidney recipients.

терминальная почечная недостаточностьтрансплантация почкиишемическая болезнь сердцареваскуляризация миокардастентирование коронарных артерийаортокоронарное шунтированиемедикаментозная терапияend-stage renal diseasekidney transplantationcoronary heart diseaseischemic heart diseasemyocardial revascularizationcoronary stentingcoronary artery bypass surgerydrug therapyReferencesThompson S, James M, Wiebe N, Hemmelgarn B, Manns B, Klarenbach S et al. Cause of Death in Patients with Reduced Kidney Function. J Am Soc Nephrol. 2015; 26 (10): 2504–2511. doi: 10.1681/ASN.2014070714.Thompson S, James M, Wiebe N, Hemmelgarn B, Manns B, Klarenbach S et al. Cause of Death in Patients with Reduced Kidney Function. J Am Soc Nephrol. 2015; 26 (10): 2504–2511. doi: 10.1681/ASN.2014070714.Sarnak MJ, Amann K, Bangalore S, Cavalcante JL, Charytan DM, Craig JC et al. Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review. 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The authors declare that there are no conflicts of interest present.