vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2023-2-148-157vtio-1645Research ArticleТрансплантомикаTransplantomicsДиагностический и терапевтический потенциал трансформирующего фактора роста β1 при трансплантации солидных органов: результаты последних исследованийDiagnostic and therapeutic potential of transforming growth factor beta 1 in solid organ transplantation: recent research findingsШарапченкоС. О.SharapchenkoS. O.

Шарапченко Софья Олеговна

123182, Москва, ул. Щукинская, д. 1. Тел. (499) 193-87-62

Sofya Sharapchenko

1, Shchukinskaya str., Moscow, 123182, Phone: (499) 193-87-62

Nyashka1512@yandex.ruМамедоваА. А.MamedovaA. A.

Анастасия Алексеевна Мамедова

Москва

Moscow

doc.mamedovaaa@gmail.comШевченкоО. П.ShevchenkoO. P.

Шевченко Ольга Павловна

Москва

Moscow

transplant2009@mail.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityRussian Federation202316072023252148157Copyright © Шарапченко С.О., Мамедова А.А., Шевченко О.П., 20232023Шарапченко С.О., Мамедова А.А., Шевченко О.П.Sharapchenko S.O., Mamedova A.A., Shevchenko O.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1645

Клинические результаты трансплантации солидных органов зависят от многих факторов, и главным среди них остается риск развития посттрансплантационных осложнений, ограничивающих выживаемость аллотрансплантата и реципиента. Концепция многофакторности повреждения органа при развитии посттрансплантационных осложнений и поиск диагностических и прогностических индикаторов патологии способствовали изучению и отбору широкого спектра протеомных и молекулярно-генетических биомаркеров, показавших эффективность при трансплантации солидных органов. Применение биомаркеров открывает дополнительные возможности для оценки риска осложнений и ранней диагностики последних, что потенциально способствует сокращению частоты инвазивных диагностических процедур. Трансформирующий фактор роста-β1 (TGF-β1) регулирует множество биологических процессов, обладает противовоспалительным и иммуносупрессивным действием, участвует в развитии иммунного ответа, а также играет ключевую роль в синтезе белков внеклеточного матрикса, дисрегуляция которого приводит к гиперпролиферации фибробластов и повышенному синтезу коллагена, и как следствие к фиброзу тканей. Вариативность диагностического и прогностического потенциала TGF-β1 показана в результатах исследований реципиентов различных солидных органов. Целью настоящего обзора стал анализ последних данных о роли TGF-β1 в развитии посттрансплантационных осложнений, а также оценка перспективы его применения как маркера патологии трансплантата или в качестве мишени для терапии.

Federation Clinical outcomes of solid organ transplantation depend on many factors. One of the main factors is the risk of post-transplant complications, which affect allograft and recipient survival. Multifactorial organ damage in post-transplant complications and the search for diagnostic and prognostic indicators of the condition have contributed to the study and selection of a wide range of proteomic and molecular genetic biomarkers, which have shown to be effective in solid organ transplantation. The use of biomarkers opens up additional possibilities for assessing the risk of complications and their early diagnosis. This potentially reduces the frequency of invasive diagnostic procedures. Transforming growth factor beta 1 (TGF-β1) regulates many biological processes, has anti-inflammatory and immunosuppressive effects, participates in immune response, and plays a key role in extracellular matrix (ECM) protein synthesis. ECM dysregulation leads to fibroblast hyperproliferation and increased collagen synthesis and, consequently, tissue fibrosis. The variability of the diagnostic and prognostic potential of TGF-β1 has been demonstrated in studies on recipients of various solid organs. The objective of this review is to analyze recent evidence on the role of TGF-β1 in the development of post-transplant complications and to assess its prospects as a marker of graft pathology or as a target for therapy.

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The authors declare that there are no conflicts of interest present.