vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2023-3-38-49vtio-1636Research ArticleКлиническая трансплантологияClinical TransplantologyРазвитие реакции «трансплантат против хозяина» у реципиента печени. Клинические наблюдения и обзор литературыDevelopment of graft-versus-host disease in a liver recipient. Clinical observations and literature reviewВосканянС. Э.VoskanyanS. E.

Кафедра пропедевтики внутренних болезней, ведение листа ожидания трансплантации печени Ростовской Области,

Москва

Moscow

voskanyan_se@mail.ruКоробкаВ. Л.KorobkaV. L.

Ростов-на-Дону

Rostov-on-Don

vyacheslavkorobka@gmail.comСюткинВ. Е.SyutkinV. E.

Москва

Moscow

vladsyutkin@gmail.comМонаховА. Р.MonakhovA. R.

Москва

Moscow

a.r.monakhov@gmail.ruМальцеваА. П.MaltsevaA. P.

Москва

Moscow

Ahveska@gmail.comПакЕ. С.PakE. S.

Пак Екатерина Сергеевна,

344015, Ростов-на-Дону, ул. Благодатная, д. 170

Rostov-on-Don

Katya_pack-k@mail.ruКоробкаР. В.KorobkaR. V.

Ростов-на-Дону

Rostov-on-Don

roman_korobka@icloud.ruКолодяжныйЕ. И.KolodyazhnyE. I.

Ростов-на-Дону

Rostov-on-Don

kolodevgenij@yandex.ruЗубенкоС. И.ZubenkoS. I.

Москва

Moscow

zubenko_transpl@yahoo.comВосканянЮ. В.VoskanyanYu. V.

Москва

Moscow

voskanyan_yv@mail.ruКоцияевВ. Ю.KotsiyaevV. Yu.

Ростов-на-Дону

Rostov-on-Don

kvu.08@mail.ruФГБУ «Государственный научный центр РФ – Федеральный медицинский биофизический центр имени А.И. Бурназяна» ФМБА РоссииРоссияBurnazyan State Medical Research CenterRussian FederationГБУ РО «Ростовская областная клиническая больница»; ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov Regional Clinical Hospital; Rostov State Medical UniversityRussian FederationФГБУ «Государственный научный центр РФ – Федеральный медицинский биофизический центр имени А.И. Бурназяна» ФМБА России; ГБУЗ «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения Москвы»РоссияBurnazyan State Medical Research Center; Sklifosovsky Research Institute for Emergency MedicineRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationГБУ РО «Ростовская областная клиническая больница»РоссияRostov Regional Clinical HospitalRussian FederationГБУ РО «Патологоанатомическое бюро»РоссияPathological Anatomy BureauRussian Federation2023170720232533849Copyright © Восканян С.Э., Коробка В.Л., Сюткин В.Е., Монахов А.Р., Мальцева А.П., Пак Е.С., Коробка Р.В., Колодяжный Е.И., Зубенко С.И., Восканян Ю.В., Коцияев В.Ю., 20232023Восканян С.Э., Коробка В.Л., Сюткин В.Е., Монахов А.Р., Мальцева А.П., Пак Е.С., Коробка Р.В., Колодяжный Е.И., Зубенко С.И., Восканян Ю.В., Коцияев В.Ю.Voskanyan S.E., Korobka V.L., Syutkin V.E., Monakhov A.R., Maltseva A.P., Pak E.S., Korobka R.V., Kolodyazhny E.I., Zubenko S.I., Voskanyan Y.V., Kotsiyaev V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1636

Реакция «трансплантат против хозяина» (РТПХ) после трансплантации печени (ТП) наблюдается у 0,2–0,3% реципиентов. Каждый случай характеризуется индивидуальными особенностями клинической картины. Не существует стандартов или клинических рекомендаций профессиональных сообществ по лечению РТПХ у реципиентов солидных органов, а летальность этих больных остается очень высокой. Мы представляем два клинических наблюдения верифицированной РТПХ, развившейся в ранние сроки после ТП, и предлагаем краткий обзор современного состояния изучения этой проблемы.

Graft-versus-host disease (GvHD) after liver transplantation (LT) occurs in 0.2–0.3% of liver transplant recipients. Each case is characterized by individual peculiarities of the clinical picture. There are no standards or clinical guidelines for the treatment of GvHD in solid organ recipients; mortality remains very high among these patients. We present two clinical cases of verified GvHD that developed early after LT, and we offer a brief review of the current state of the art in the study of this problem.

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The authors declare that there are no conflicts of interest present.