vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2023-1-106-112vtio-1600Research ArticleТрансплантация сердца и вспомогательное кровообращениеHeart Transplantation and Assisted CirculationГемодинамическая оценка устройства генерации пульсирующего потока в системах обхода левого желудочка сердцаHemodynamic evaluation of pulsatile-flow generating device in left ventricular assist devicesБучневА. С.BuchnevA. S.

Бучнев Александр Сергеевич - лаборатория биотехнических систем.

123182, Москва, ул. Щукинская, д. 1. Тел (926) 470-09-88

Alexander Buchnev

1, Shchukinskaya str., Moscow, 123182. Phone: (926) 470-09-88

labbts@mail.ruКулешовА. П.KuleshovA. P.

Москва

Moscow

ЕсиповаО. Ю.EsipovaO. Yu.

Москва

Moscow

ДробышевА. А.DrobyshevA. A.

Москва

Moscow

ГрудининН. В.GrudininN. V.

Москва

Moscow

ФГБУ Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова, Минздрав РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian Federation202308042023251106112Copyright © Бучнев А.С., Кулешов А.П., Есипова О.Ю., Дробышев А.А., Грудинин Н.В., 20232023Бучнев А.С., Кулешов А.П., Есипова О.Ю., Дробышев А.А., Грудинин Н.В.Buchnev A.S., Kuleshov A.P., Esipova O.Y., Drobyshev A.A., Grudinin N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1600Цель работы

Цель работы: исследование эффективности устройства генерации пульсирующего потока крови при работе осевого насоса с постоянной скоростью вращения для использования в системе обхода левого желудочка сердца.

Материалы и методы

Материалы и методы. Устройство генерации пульсирующего потока, именуемое в дальнейшем «пульсатор», состоит из переменного гидравлического сопротивления, выполненного в виде корпуса с установленной внутри него трубкой из эластичного биосовместимого материала с внутренним диаметром 11 мм. В систолической фазе левого желудочка сердца за счет систолического давления эластичная трубка полностью раскрывается, минимизируя сопротивление выброса крови. В диастолической фазе за счет присасывающего действия насоса, работающего в режиме постоянных оборотов, эластичная трубка частично смыкается, создавая потоку крови дополнительное гидравлическое сопротивление, что приводит к уменьшению диастолического аортального давления. Сравнительная оценка работы осевого насоса в пульсирующем и непульсирующем режиме проводилась на гидродинамическом стенде, имитирующем сердечно-сосудистую систему с расчетом индексов: пульсации артериального давления (Ip), внутринасосной пульсации потока (AQ), энергии эквивалентного давления (ЕЕР) и избыточной гемодинамической энергии (SHE).

Результаты

Результаты. При сравнении работы осевого насоса в пульсирующем и непрерывном режиме индекс пульсации артериального давления увеличивался в 2,13 ± 0,2 раза, индекс внутринасосной пульсации увеличивался в 3,2 ± 0,2 раза, индекс SHE увеличивался в 2,7 ± 0,15 раза, индекс ЕЕР оставался без изменения.

Objective

Objective: to investigate the efficiency of a device that generates pulsatile flow during constant-speed axial-flow pump operation for use in left ventricular assist devices.

Materials and methods

Materials and methods. The pulsatile flow-generating device, hereinafter referred to as «pulsator», consists of a variable hydraulic resistance made in the form of a hull. A tube of elastic biocompatible material featuring an inner diameter of 11 mm is installed inside it. In the systolic phase of the left ventricle, due to systolic pressure, the elastic tube is fully opened, minimizing resistance to blood ejection. In the diastolic phase, due to suction action of the flow pump operating in constant revolutions, the elastic tube partially closes, creating additional hydraulic resistance to blood flow, which leads to reduced diastolic aortic pressure. Comparative assessment of axial-flow pump operation in pulsating and non-pulsating modes was carried out on a hydrodynamic stand that simulated the cardiovascular system. The following indices were calculated: arterial pressure pulsation (Ip), in-pump flow pulsation (AQ), energy equivalent pressure (EEP) and surplus hemodynamic energy (SHE).

Results

Results. When comparing axial-flow pump operation in pulsatile and continuous mode, arterial pressure pulsation index, in-pump pulsation index, and SHE index increased by 2.13 ± 0.2, 3.2 ± 0.2, and 2.7 ± 0.15 times, respectively, while EER index remained unchanged.

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The authors declare that there are no conflicts of interest present.