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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2023-1-90-98</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1569</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Трансплантация сердца и вспомогательное кровообращение</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Heart Transplantation and Assisted Circulation</subject></subj-group></article-categories><title-group><article-title>Механическая поддержка кровообращения у детей: патофизиология педиатрического гемостаза и алгоритмы послеоперационного ведения</article-title><trans-title-group xml:lang="en"><trans-title>Pediatric mechanical circulatory support: pathophysiology of pediatric hemostasis and postoperative management algorithms</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колоскова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Koloskova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колоскова Надежда Николаевна - заведующая отделением кардиологии в ФГБУ НМИЦ ТИО им.ак.В.И.Шумакова МЗ РФ</p><p>123182, ул. Щукинская, д. 1. Тел. (926) 651-40-64</p></bio><bio xml:lang="en"><p>Nadezda Koloskova</p><p>1, Shchukinskaya str., Moscow, 123182. Phone: (926) 651-40-64</p></bio><email xlink:type="simple">nkrasotka@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халилулин</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalilulin</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тимур Абдулнаимович Халилулин</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">timur-medicina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябцев</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabtsev</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Вадимович Рябцев</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dvryabtsev@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попцов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Poptsov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виталий Николаевич Попцов</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">poptsov_vit@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова, Минздрав России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Shumakov National Medical Research Center of Transplantology and Artificial Organs</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова, Минздрав России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова, Минздрав России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>08</day><month>04</month><year>2023</year></pub-date><volume>25</volume><issue>1</issue><fpage>90</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Колоскова Н.Н., Халилулин Т.А., Рябцев Д.В., Попцов В.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Колоскова Н.Н., Халилулин Т.А., Рябцев Д.В., Попцов В.Н.</copyright-holder><copyright-holder xml:lang="en">Koloskova N.N., Khalilulin T.A., Ryabtsev D.V., Poptsov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1569">https://journal.transpl.ru/vtio/article/view/1569</self-uri><abstract><p>Хроническая сердечная недостаточность на фоне врожденных пороков сердца, преимущественно в раннем детском возрасте, или различных форм кардиомиопатий, чаще встречающихся в подростковом возрасте, представляет собой важную причину заболеваемости и смертности среди детского населения [1, 2]. Ввиду увеличения за последние два десятилетия количества пациентов, страдающих терминальной стадией хронической сердечной недостаточности, рефрактерной к медикаментозной терапии, и существующего дефицита донорских органов в педиатрической практике вопрос о применении длительной механической поддержки кровообращения становится все более актуальным. Ведение пациентов представляет собой мультидисциплинарную задачу, так как длительное применение антикоагулянтной и антитромбоцитарной терапии, направленной на предупреждение тромбоза искусственного желудочка сердца, имеет потенциально опасные, жизнеугрожающие осложнения, а именно острое нарушение мозгового кровообращения по геморрагическому типу и кровотечения различной степени тяжести.</p></abstract><trans-abstract xml:lang="en"><p>Chronic heart failure (CHF) against the background of congenital heart disease, mostly in early childhood, or various forms of cardiomyopathies, more common in teenage age, represents an important cause of morbidity and mortality in the pediatric population [1, 2]. Due to the increase in the number of patients suffering from refractory end-stage CHF over the last two decades, and the current shortage of donor organs in pediatric practice, the issue of long-term mechanical circulatory support (MCS) is becoming increasingly a pressing problem. Patient management is a multidisciplinary task, since prolonged use of anticoagulant and antiplatelet therapy to prevent ventricular thrombosis has potentially life-threatening complications - acute hemorrhagic stroke and bleeding of varying severity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечная недостаточность у детей</kwd><kwd>длительная механическая поддержка кровообращения</kwd><kwd>антикоагулянтная терапия</kwd><kwd>антиагрегантная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart failure in children</kwd><kwd>long-term mechanical circulatory support</kwd><kwd>anticoagulant therapy</kwd><kwd>antiplatelet therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Masarone D, Valente F, Rubino M, Vastarella R, Gra-vino R, Rea A et al. Pediatric Heart Failure: A Practical Guide to Diagnosis and Management. 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