vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2022-4-54-59vtio-1568Research ArticleТрансплантация сердца и вспомогательное кровообращениеHeart Transplantation and Assisted CirculationМеханическая поддержка лимфоциркуляции в условиях острой декомпенсированной сердечной недостаточности. Исследование на гидродинамическом стендеMechanized lymphatic drainage in acute decompensated heart failure. A study on a hydrodynamic test benchБучневА. С.BuchnevA. S.

Бучнев Александр Сергеевич

123182, Москва, ул. Щукинская, д. 1

Тел. (926) 470-09-88

Alexander Buchnev

1, Shchukinskaya str., Moscow, 123182, Russian Federation

Phone: (926) 470-09-88

labbts@mail.ruИткинГ. П.ItkinG. P.

 Москва

Moscow

ДробышевА. А.DrobyshevA. A.

 Москва

Moscow

КулешовА. П.KuleshovA. P.

 Москва

Moscow

ЕсиповаО. Ю.EsipovaO. Yu.

 Москва

Moscow

СырбуА. И.SyrbuA. I.

 Москва

Moscow

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Московский физико-технический институт (национальный исследовательский университет)»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Moscow Institute of Physics and TechnologyRussian Federation2022201020222445459Copyright © Бучнев А.С., Иткин Г.П., Дробышев А.А., Кулешов А.П., Есипова О.Ю., Сырбу А.И., 20222022Бучнев А.С., Иткин Г.П., Дробышев А.А., Кулешов А.П., Есипова О.Ю., Сырбу А.И.Buchnev A.S., Itkin G.P., Drobyshev A.A., Kuleshov A.P., Esipova O.Y., Syrbu A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1568Цель работы

Цель работы. Исследование эффективности нового метода механической поддержки лимфоциркуляции в условиях моделирования острой декомпенсированной сердечной недостаточности (ОДСН) за счет локального снижения венозного давления в области выхода лимфы из грудного потока.

Материалы и методы

Материалы и методы. Основные компоненты устройства: катетер со встроенными входным и выходным механическими клапанами, предназначенный для введения в левую плечеголовную вену через левую внутреннюю яремную вену, с экстракорпоральной системой привода, выполненной в виде бесклапанного насоса-пульсатора с ударным выбросом 10 мл и контроллером, обеспечивающим заданную частоту и скважность импульсов разрежения/давления. Принцип действия устройства основан на локальном снижении венозного давления в зоне выхода лимфы из грудного протока (в зоне слияния левых внутренней яремной и подключичной вен).

Результаты

Результаты. При моделировании на гидродинамическом стенде гемодинамики, соответствующей условиям ОДСН, верхний венозный поток через левую плечеголовную вену составлял 0,4 л/мин, давление в области выхода лимфы из грудного потока за счет работы устройства механической поддержки снижалось с 20–25 до 0–5 мм рт. ст. при соотношении длительности фазы всасывания/нагнетания 0,2/0,8 при частоте работы насоса-пульсатора от 30 до 60 уд/мин.

Objective

Objective: to investigate the effectiveness of a new mechanized lymphatic drainage method in acute decompensated heart failure (ADHF) modeling through local reduction in venous pressure in the site of lymphatic drainage from the thoracic duct.

Materials and methods

Materials and methods. Main components of the device are a catheter with built-in inlet and outlet mechanical valves designed for insertion into the left brachiocephalic vein through the left internal jugular vein. It comes with an extracorporeal drive system made as a valveless pulsator pump with a 10 ml shock discharge and a controller ensuring preset frequency and pressure/rarefaction duty cycle. The operating principle of the device is based on local reduction of venous pressure in the site of lymphatic drainage from the thoracic duct (in the junction of the left internal jugular and subclavian veins).

Results

Results. When modeling hydrodynamics under ADHF conditions on a hydrodynamic test bench, the upper venous flow through the left brachiocephalic vein was 0.4 l/min, the pressure in the site of lymphatic drainage from the thoracic duct, was decreased from 20–25 mmHg to 0–5 mmHg due to operation of the mechanized drainage device with suction/injection phase duration ratio 0.2/0.8 and pulsator pump operating frequency from 30 to 60 beats/min.

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The authors declare that there are no conflicts of interest present.