<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2022-3-94-101</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1541</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Трансплантомика</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Transplantomics</subject></subj-group></article-categories><title-group><article-title>Биомаркеры фиброза трансплантированной почки</article-title><trans-title-group xml:lang="en"><trans-title>Biomarkers of renal transplant fibrosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быстрова</surname><given-names>О. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bystrova</surname><given-names>O. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Быстрова Ольга Романовна</p><p>Адрес: 123182, Москва, ул. Щукинская, д. 1Тел. (963) 757-08-91</p></bio><bio xml:lang="en"><p>Olga Bystrova</p><p>Address: 1, Shchukinskaya str., Moscow, 123182Phone: (963) 757-08-91</p></bio><email xlink:type="simple">bystrova.olga@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стаханова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stakhanova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильчук</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilchuk</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Улыбышева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ulybysheva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гичкун</surname><given-names>О. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Gichkun</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сайдулаев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Saydulaev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевченко</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevchenko</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Shumakov National Medical Research Center of Transplantology and Artificial Organs</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>24</day><month>08</month><year>2022</year></pub-date><volume>24</volume><issue>3</issue><fpage>94</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Быстрова О.Р., Стаханова Е.А., Ильчук М.И., Улыбышева А.А., Гичкун О.Е., Сайдулаев Д.А., Шевченко О.П., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Быстрова О.Р., Стаханова Е.А., Ильчук М.И., Улыбышева А.А., Гичкун О.Е., Сайдулаев Д.А., Шевченко О.П.</copyright-holder><copyright-holder xml:lang="en">Bystrova O.R., Stakhanova E.A., Ilchuk M.I., Ulybysheva A.A., Gichkun O.E., Saydulaev D.A., Shevchenko O.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1541">https://journal.transpl.ru/vtio/article/view/1541</self-uri><abstract><p>Фиброз является одной из причин потери аллотрансплантата почки, особенно в поздние сроки после трансплантации (частота встречаемости – до 65% через 2 года). Целью данного обзора литературы является анализ исследований, изучающих методы неинвазивного мониторинга развития фиброза почечного трансплантата.</p></abstract><trans-abstract xml:lang="en"><p>Fibrosis is one of the causes of kidney allograft loss, especially late after transplantation (up to 65% incidence after 2 years). The purpose of this literature review is to analyze studies examining noninvasive monitoring techniques for renal graft fibrosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фиброз</kwd><kwd>трансплантация почки</kwd><kwd>биомаркеры</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fibrosis</kwd><kwd>kidney transplantation</kwd><kwd>biomarkers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nankivell BJ, Borrows RJ, Fung CL, O’Connell PJ, Chapman JR, Allen RD. Delta analysis of posttransplantation tubulointerstitial damage. Transplantation. 2004; 78 (3): 434–441.</mixed-citation><mixed-citation xml:lang="en">Nankivell BJ, Borrows RJ, Fung CL, O’Connell PJ, Chapman JR, Allen RD. Delta analysis of posttransplantation tubulointerstitial damage. Transplantation. 2004; 78 (3): 434–441.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Stolyarevich ES, Tomilina NA. Understanding evolution on the causes of late renal allograft dysfunction. Russian Journal of Transplantology and Artificial Organs. 2015; 17 (2): 113–115.</mixed-citation><mixed-citation xml:lang="en">Stolyarevich ES, Tomilina NA. Understanding evolution on the causes of late renal allograft dysfunction. Russian Journal of Transplantology and Artificial Organs. 2015; 17 (2): 113–115.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Granata S, Benedetti C, Gambaro G, Zaza G. Kidney allograft fibrosis: what we learned from latest translational research studies. Journal of Nephrology. 2020; 33 (6): 1201–1211.</mixed-citation><mixed-citation xml:lang="en">Granata S, Benedetti C, Gambaro G, Zaza G. Kidney allograft fibrosis: what we learned from latest translational research studies. Journal of Nephrology. 2020; 33 (6): 1201–1211.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Boor P, Floege J. Renal allograft fibrosis: Biology and therapeutic targets. American Journal of Transplantation. 2015; 15 (4): 863–886.</mixed-citation><mixed-citation xml:lang="en">Boor P, Floege J. Renal allograft fibrosis: Biology and therapeutic targets. American Journal of Transplantation. 2015; 15 (4): 863–886.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Saritas T, Kramann R. Kidney Allograft Fibrosis: Diagnostic and Therapeutic Strategies. Transplantation. 2021; 105 (10): e114–e130.</mixed-citation><mixed-citation xml:lang="en">Saritas T, Kramann R. Kidney Allograft Fibrosis: Diagnostic and Therapeutic Strategies. Transplantation. 2021; 105 (10): e114–e130.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mannon RB, Matas AJ, Grande J, Leduc R, Connett J, Kasiske B et al. Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure. Am J Transplant. 2010; 10 (9): 2066–2073.</mixed-citation><mixed-citation xml:lang="en">Mannon RB, Matas AJ, Grande J, Leduc R, Connett J, Kasiske B et al. Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure. Am J Transplant. 2010; 10 (9): 2066–2073.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Modena BD, Kurian SM, Gaber LW, Waalen J, Su AI, Gelbart T et al. Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes. Am J Transplant. 2016; 16 (7): 1982–1998.</mixed-citation><mixed-citation xml:lang="en">Modena BD, Kurian SM, Gaber LW, Waalen J, Su AI, Gelbart T et al. Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes. Am J Transplant. 2016; 16 (7): 1982–1998.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D. Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol. 2008; 83 (6): 1323–1333.</mixed-citation><mixed-citation xml:lang="en">Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D. Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol. 2008; 83 (6): 1323–1333.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bontha SV, Maluf DG, Archer KJ, Dumur CI, Dozmorov MG, King AL et al. Effects of DNA Methylation on Progression to Interstitial Fibrosis and Tubular Atrophy in Renal Allograft Biopsies: A Multi-Omics Approach. Am J Transplant. 2017; 17 (12): 3060–3075.</mixed-citation><mixed-citation xml:lang="en">Bontha SV, Maluf DG, Archer KJ, Dumur CI, Dozmorov MG, King AL et al. Effects of DNA Methylation on Progression to Interstitial Fibrosis and Tubular Atrophy in Renal Allograft Biopsies: A Multi-Omics Approach. Am J Transplant. 2017; 17 (12): 3060–3075.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lipphardt M, Song JW, Matsumoto K, Dadafarin S, Dihazi H, Muller G, Goligorsky MS. The third path of tubulointerstitial fibrosis: aberrant endothelial secretome. Kidney Int. 2017; 92 (3): 558–568.</mixed-citation><mixed-citation xml:lang="en">Lipphardt M, Song JW, Matsumoto K, Dadafarin S, Dihazi H, Muller G, Goligorsky MS. The third path of tubulointerstitial fibrosis: aberrant endothelial secretome. Kidney Int. 2017; 92 (3): 558–568.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Melk A, Schmidt BM, Vongwiwatana A, Rayner DC, Halloran PF. Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney. Am J Transplant. 2005; 5 (6): 1375–1382.</mixed-citation><mixed-citation xml:lang="en">Melk A, Schmidt BM, Vongwiwatana A, Rayner DC, Halloran PF. Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney. Am J Transplant. 2005; 5 (6): 1375–1382.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenberger C, Eckardt KU. Oxygenation of the Transplanted Kidney. Semin Nephrol. 2019; 39 (6): 554–566.</mixed-citation><mixed-citation xml:lang="en">Rosenberger C, Eckardt KU. Oxygenation of the Transplanted Kidney. Semin Nephrol. 2019; 39 (6): 554–566.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Land W, Schneeberger H, Schleibner S, Illner WD, Abendroth D, Rutili G et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation. 1994; 57 (2): 211–217.</mixed-citation><mixed-citation xml:lang="en">Land W, Schneeberger H, Schleibner S, Illner WD, Abendroth D, Rutili G et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation. 1994; 57 (2): 211–217.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sun YB, Qu X, Caruana G, Li J. The origin of renal fibroblasts/ myofibroblasts and the signals that trigger fibrosis. Differentiation. 2016; 92 (3): 102–107.</mixed-citation><mixed-citation xml:lang="en">Sun YB, Qu X, Caruana G, Li J. The origin of renal fibroblasts/ myofibroblasts and the signals that trigger fibrosis. Differentiation. 2016; 92 (3): 102–107.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolic-Paterson DJ, Wang S, Lan HY. Macrophages promote renal fibrosis through direct and indirect mechanisms. Kidney Int Suppl. 2014; 4 (1): 34–38.</mixed-citation><mixed-citation xml:lang="en">Nikolic-Paterson DJ, Wang S, Lan HY. Macrophages promote renal fibrosis through direct and indirect mechanisms. Kidney Int Suppl. 2014; 4 (1): 34–38.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Тoki D, Zhang W, Hor KL, Liuwantara D, Alexander SI, Yi Z et al. The role of macrophages in the development of human renal allograft fibrosis in the first year after transplantation. Am J Transplant. 2014; 14 (9): 2126–2136.</mixed-citation><mixed-citation xml:lang="en">Тoki D, Zhang W, Hor KL, Liuwantara D, Alexander SI, Yi Z et al. The role of macrophages in the development of human renal allograft fibrosis in the first year after transplantation. Am J Transplant. 2014; 14 (9): 2126–2136.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res. 2005; 97 (6): 512–523.</mixed-citation><mixed-citation xml:lang="en">Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res. 2005; 97 (6): 512–523.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Goodall KJ, Poon IK, Phipps S, Hulett MD. Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. PLoS One. 2014; 9 (10): e109596.</mixed-citation><mixed-citation xml:lang="en">Goodall KJ, Poon IK, Phipps S, Hulett MD. Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. PLoS One. 2014; 9 (10): e109596.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA et al. Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell. 2015; 16 (1): 51–66.</mixed-citation><mixed-citation xml:lang="en">Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA et al. Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell. 2015; 16 (1): 51–66.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Quaglia M, Merlotti G, Guglielmetti G, Castellano G, Cantaluppi V. Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction. Int J Mol Sci. 2020; 21 (15): 5404.</mixed-citation><mixed-citation xml:lang="en">Quaglia M, Merlotti G, Guglielmetti G, Castellano G, Cantaluppi V. Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction. Int J Mol Sci. 2020; 21 (15): 5404.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sotomayor CG, Te Velde-Keyzer CA, Diepstra A, van Londen M, Pol RA, Post A et al. Galectin-3 and Risk of Late Graft Failure in Kidney Transplant Recipients: A 10-year Prospective Cohort Study. Transplantation. 2021; 105 (5): 1106–1115.</mixed-citation><mixed-citation xml:lang="en">Sotomayor CG, Te Velde-Keyzer CA, Diepstra A, van Londen M, Pol RA, Post A et al. Galectin-3 and Risk of Late Graft Failure in Kidney Transplant Recipients: A 10-year Prospective Cohort Study. Transplantation. 2021; 105 (5): 1106–1115.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Djamali A. Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts. Am J Physiol Renal Physiol. 2007; 293 (2): F445–455.</mixed-citation><mixed-citation xml:lang="en">Djamali A. Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts. Am J Physiol Renal Physiol. 2007; 293 (2): F445–455.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gottmann U, Oltersdorf J, Schaub M, Knoll T, Back WE, van der Woude FJ et al. Oxidative stress in chronic renal allograft nephropathy in rats: effects of long-term treatment with carvedilol, BM 91.0228, or alpha-tocopherol. J Cardiovasc Pharmacol. 2003; 42 (3): 442–450.</mixed-citation><mixed-citation xml:lang="en">Gottmann U, Oltersdorf J, Schaub M, Knoll T, Back WE, van der Woude FJ et al. Oxidative stress in chronic renal allograft nephropathy in rats: effects of long-term treatment with carvedilol, BM 91.0228, or alpha-tocopherol. J Cardiovasc Pharmacol. 2003; 42 (3): 442–450.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Celie JW, Rutjes NW, Keuning ED, Soininen R, Heljasvaara R, Pihlajaniemi T et al. Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion. Am J Pathol. 2007; 170 (6): 1865–1878.</mixed-citation><mixed-citation xml:lang="en">Celie JW, Rutjes NW, Keuning ED, Soininen R, Heljasvaara R, Pihlajaniemi T et al. Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion. Am J Pathol. 2007; 170 (6): 1865–1878.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Carew RM, Wang B, Kantharidis P. The role of EMT in renal fibrosis. Cell Tissue Res. 2012; 347 (1): 103–116.</mixed-citation><mixed-citation xml:lang="en">Carew RM, Wang B, Kantharidis P. The role of EMT in renal fibrosis. Cell Tissue Res. 2012; 347 (1): 103–116.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Garsen M, Rops ALWMM, Rabelink TJ, Berden JHM, van der Vlag J. The role of heparanase and the endothelial glycocalyx in the development of proteinuria. Nephrol Dial Transplant. 2014; 29 (1): 49–55.</mixed-citation><mixed-citation xml:lang="en">Garsen M, Rops ALWMM, Rabelink TJ, Berden JHM, van der Vlag J. The role of heparanase and the endothelial glycocalyx in the development of proteinuria. Nephrol Dial Transplant. 2014; 29 (1): 49–55.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys MMRF et al. Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. J Clin Med. 2020; 9 (1): 253.</mixed-citation><mixed-citation xml:lang="en">Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys MMRF et al. Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. J Clin Med. 2020; 9 (1): 253.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Salvadori M, Rosso G, Bertoni E. Update on ischemiareperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant. 2015; 5 (2): 52.</mixed-citation><mixed-citation xml:lang="en">Salvadori M, Rosso G, Bertoni E. Update on ischemiareperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant. 2015; 5 (2): 52.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bedi S, Vidyasagar A, Djamali A. Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev (Orlando). 2008; 22 (1): 1–5.</mixed-citation><mixed-citation xml:lang="en">Bedi S, Vidyasagar A, Djamali A. Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev (Orlando). 2008; 22 (1): 1–5.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Richter K, Kietzmann T. Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res. 2016; 365 (3): 591–605.</mixed-citation><mixed-citation xml:lang="en">Richter K, Kietzmann T. Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res. 2016; 365 (3): 591–605.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol. 2011; 7 (12): 684–696.</mixed-citation><mixed-citation xml:lang="en">Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol. 2011; 7 (12): 684–696.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 2010; 16 (5): 535–543.</mixed-citation><mixed-citation xml:lang="en">Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 2010; 16 (5): 535–543.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Desvignes C, Dabadie A, Aschero A, Ruocco A, Garaix F, Daniel L et al. Technical feasibility and correlations between shear-wave elastography and histology in kidney fibrosis in children. Pediatr Radiol. 2021; 51 (10): 1879–1888.</mixed-citation><mixed-citation xml:lang="en">Desvignes C, Dabadie A, Aschero A, Ruocco A, Garaix F, Daniel L et al. Technical feasibility and correlations between shear-wave elastography and histology in kidney fibrosis in children. Pediatr Radiol. 2021; 51 (10): 1879–1888.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ma MK, Law HK, Tse KS, Chan KW, Chan GC, Yap DY et al. Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis. Int J Urol. 2018; 25 (5): 450–455.</mixed-citation><mixed-citation xml:lang="en">Ma MK, Law HK, Tse KS, Chan KW, Chan GC, Yap DY et al. Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis. Int J Urol. 2018; 25 (5): 450–455.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">McArthur C, Geddes CC, Baxter GM. Early measurement of pulsatility and resistive indexes: correlation with long-term renal transplant function. Radiology. 2011; 259 (1): 278–285.</mixed-citation><mixed-citation xml:lang="en">McArthur C, Geddes CC, Baxter GM. Early measurement of pulsatility and resistive indexes: correlation with long-term renal transplant function. Radiology. 2011; 259 (1): 278–285.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Полещук ЛА. Характеристика почечной гемодинамики у детей с заболеваниями почек (обзор литературы). Нефрология и диализ. 2006; 8 (3): 225–231.</mixed-citation><mixed-citation xml:lang="en">Poleshchuk LA. Kharakteristika pochechnoy gemodinamiki u detey s zabolevaniyami pochek (obzor literatury). Nefrologiya i dializ. 2006; 8 (3): 225–231.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Пыков МИ, Эктов ДБ, Васильев КГ, Кушнир БЛ, Мартыненкова АВ. Параметры гемодинамики почечного трансплантата с разной степенью интерстициального фиброза и тубулярной атрофии в отдаленном посттрансплантационном периоде у детей. Вестник Российского научного центра рентгенорадиологии. 2021; 21 (4): 138–154.</mixed-citation><mixed-citation xml:lang="en">Pykov MI, Ektov DB, Vasil’yev KG, Kushnir BL, Martynenkova AV. Parametry gemodinamiki pochechnogo transplantata s raznoy stepen’yu interstitsial’nogo fibroza i tubulyarnoy atrofii v otdalennom posttransplantatsionnom periode u detey. Vestnik Rossiyskogo nauchnogo tsentra rentgenoradiologii. 2021; 21 (4): 138–154.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Vanhove T, Goldschmeding R, Kuypers D. Kidney fibrosis: origins and interventions. Transplantation. 2017; 101 (4): 713–726.</mixed-citation><mixed-citation xml:lang="en">Vanhove T, Goldschmeding R, Kuypers D. Kidney fibrosis: origins and interventions. Transplantation. 2017; 101 (4): 713–726.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Servais A, Meas-Yedid V, Noel LH, Martinez F, Panterne C, Kreis H et al. Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. Am J Transplant. 2011; 11 (7): 1456–1463.</mixed-citation><mixed-citation xml:lang="en">Servais A, Meas-Yedid V, Noel LH, Martinez F, Panterne C, Kreis H et al. Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis. Am J Transplant. 2011; 11 (7): 1456–1463.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Vahed SZ, Samadi N, Ardalan M. Transplantation diagnosis of interstitial fibrosis and tubular atrophy in kidney allograft implementation of MicroRNAs. Iranian Journal of Kidney Diseases. 2014; 8 (1): 4–12.</mixed-citation><mixed-citation xml:lang="en">Vahed SZ, Samadi N, Ardalan M. Transplantation diagnosis of interstitial fibrosis and tubular atrophy in kidney allograft implementation of MicroRNAs. Iranian Journal of Kidney Diseases. 2014; 8 (1): 4–12.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P. The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis? Fibrogenesis Tissue Repair. 2014; 7 (1): 1–4.</mixed-citation><mixed-citation xml:lang="en">Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P. The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis? Fibrogenesis Tissue Repair. 2014; 7 (1): 1–4.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hartono C, Muthukumar T, Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts. Current Opinion in Organ Transplantation. 2010; 15: 35–41.</mixed-citation><mixed-citation xml:lang="en">Hartono C, Muthukumar T, Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts. Current Opinion in Organ Transplantation. 2010; 15: 35–41.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Saritas T, Kramann R. Kidney allograft fibrosis: diagnostic and therapeutic strategies. Transplantation. 2021; 105 (10): e114–e130.</mixed-citation><mixed-citation xml:lang="en">Saritas T, Kramann R. Kidney allograft fibrosis: diagnostic and therapeutic strategies. Transplantation. 2021; 105 (10): e114–e130.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Nankivell BJ, P’Ng ChH, O’Connell PhJ, Chapman JR. Calcineurin inhibitor nephrotoxicity through the lens of longitudinal histology: comparison of cyclosporine and tacrolimus eras. Transplantation. 2016; 100 (8): 1723– 1731.</mixed-citation><mixed-citation xml:lang="en">Nankivell BJ, P’Ng ChH, O’Connell PhJ, Chapman JR. Calcineurin inhibitor nephrotoxicity through the lens of longitudinal histology: comparison of cyclosporine and tacrolimus eras. Transplantation. 2016; 100 (8): 1723– 1731.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Manfro RC, Aquino-Dias EC, Joelsons G, Nogare AL, Carpio VN, Goncalves LF. Noninvasive Tim-3 messenger RNA evaluation in renal transplant recipients with graft dysfunction. Transplantation. 2008; 86 (12): 1869–1874.</mixed-citation><mixed-citation xml:lang="en">Manfro RC, Aquino-Dias EC, Joelsons G, Nogare AL, Carpio VN, Goncalves LF. Noninvasive Tim-3 messenger RNA evaluation in renal transplant recipients with graft dysfunction. Transplantation. 2008; 86 (12): 1869–1874.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Isaka Y. Targeting TGF-β Signaling in Kidney Fibrosis. Int J Mol Sci. 2018; 19 (9): 2532. doi: 10.3390/ijms19092532.</mixed-citation><mixed-citation xml:lang="en">Isaka Y. Targeting TGF-β Signaling in Kidney Fibrosis. Int J Mol Sci. 2018; 19 (9): 2532. doi: 10.3390/ijms19092532.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolova PN, Ivanova MI, Mihailova S, Mihaylova A, Baltadjieva D, Simeonov PL et al. Cytokine gene polymorphism in kidney transplantation – Impact of TGF-β1, TNF-α and IL-6 on graft outcome. Transplant immunology. 2008; 18 (4): 344–348.</mixed-citation><mixed-citation xml:lang="en">Nikolova PN, Ivanova MI, Mihailova S, Mihaylova A, Baltadjieva D, Simeonov PL et al. Cytokine gene polymorphism in kidney transplantation – Impact of TGF-β1, TNF-α and IL-6 on graft outcome. Transplant immunology. 2008; 18 (4): 344–348.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Mu HJ, Xie P, Chen JY, Gao F, Zou J, Zhang J, Zhang B. Association of TNF-α, TGF-β1, IL-10, IL-6, and IFN-γ gene polymorphism with acute rejection and infection in lung transplant recipients. Clin Transplant. 2014; 28 (9): 1016–1024.</mixed-citation><mixed-citation xml:lang="en">Mu HJ, Xie P, Chen JY, Gao F, Zou J, Zhang J, Zhang B. Association of TNF-α, TGF-β1, IL-10, IL-6, and IFN-γ gene polymorphism with acute rejection and infection in lung transplant recipients. Clin Transplant. 2014; 28 (9): 1016–1024.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Курабекова РМ, Гичкун ОЕ, Мещеряков СВ, Шевченко ОП. Роль полиморфизма гена трансформирующего фактора роста β1 в развитии осложнений после трансплантации солидных органов. Вестник трансплантологии и искусственных органов. 2021; 23 (3): 180–185.</mixed-citation><mixed-citation xml:lang="en">Kurabekova RM, Gichkun OE, Meshcheryakov SV, Shevchenko OP. Rol’ polimorfizma gena transformiruyushchego faktora rosta β1 v razvitii oslozhneniy posle transplantatsii solidnykh organov. Vestnik transplantologii i iskusstvennykh organov. 2021; 23 (3): 180–185.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Guan Q, Li S, Gao S, Chen H, Nguan CY, Du C. Reduction of chronic rejection of renal allografts by anti-transforming growth factor-β antibody therapy in a rat model. Am J Physiol Renal Physiol. 2013; 305 (2): F199–207.</mixed-citation><mixed-citation xml:lang="en">Guan Q, Li S, Gao S, Chen H, Nguan CY, Du C. Reduction of chronic rejection of renal allografts by anti-transforming growth factor-β antibody therapy in a rat model. Am J Physiol Renal Physiol. 2013; 305 (2): F199–207.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Djamali A, Vidyasagar A, Yagci G, Huang LJ, Reese S. Mycophenolic acid may delay allograft fibrosis by inhibiting transforming growth factor-beta1-induced activation of Nox-2 through the nuclear factor-kappaB pathway. Transplantation. 2010; 90 (4): 387–393.</mixed-citation><mixed-citation xml:lang="en">Djamali A, Vidyasagar A, Yagci G, Huang LJ, Reese S. Mycophenolic acid may delay allograft fibrosis by inhibiting transforming growth factor-beta1-induced activation of Nox-2 through the nuclear factor-kappaB pathway. Transplantation. 2010; 90 (4): 387–393.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Garber K. Companieswaver in efforts to target transforming growth factor beta in cancer. Journal of the National Cancer Institute. 2009; 101: 1664–1667.</mixed-citation><mixed-citation xml:lang="en">Garber K. Companieswaver in efforts to target transforming growth factor beta in cancer. Journal of the National Cancer Institute. 2009; 101: 1664–1667.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Khanna AK, Cairns VR, Becker CG, Hosenpud JD. Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine. Transplantation. 1999; 67: 882–889.</mixed-citation><mixed-citation xml:lang="en">Khanna AK, Cairns VR, Becker CG, Hosenpud JD. Transforming growth factor (TGF)-beta mimics and anti-TGF-beta antibody abrogates the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-beta in immunosuppression and nephrotoxicity of cyclosporine. Transplantation. 1999; 67: 882–889.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Шевченко ОП, Улыбышева АА, Гичкун ОЕ, Можейко НП, Стаханова ЕА, Кван ВС и др. Галектин-3 при отторжении и фиброзе трансплантированного сердца. Вестник трансплантологии и искусственных органов. 2019; 21 (3): 145–150.</mixed-citation><mixed-citation xml:lang="en">Shevchenko OP, Ulybysheva AA, Gichkun OE, Mozheyko NP, Stakhanova EA, Kvan VS i dr. Galektin-3 pri ottorzhenii i fibroze transplantirovannogo serdtsa. Vestnik transplantologii i iskusstvennykh organov. 2019; 21 (3): 145–150.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Chen SC, Kuo PL. The role of galectin-3 in the kidneys. International Journal of Molecular Sciences. 2016; 17 (4): 565.</mixed-citation><mixed-citation xml:lang="en">Chen SC, Kuo PL. The role of galectin-3 in the kidneys. International Journal of Molecular Sciences. 2016; 17 (4): 565.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Gyamdzhyan KA, Kukes VG, Maksimov ML. Clinical value of determining galectin-3 in patients with chronic heart failure. Medical Council. Remedium. 2017; 7: 63–68.</mixed-citation><mixed-citation xml:lang="en">Gyamdzhyan KA, Kukes VG, Maksimov ML. Clinical value of determining galectin-3 in patients with chronic heart failure. Medical Council. Remedium. 2017; 7: 63–68.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Ostendorf T, Eitner F, Floege J. The PDGF family in renal fibrosis. Journal of Pediatric Nephrology. 2012; 27: 1041–1050.</mixed-citation><mixed-citation xml:lang="en">Ostendorf T, Eitner F, Floege J. The PDGF family in renal fibrosis. Journal of Pediatric Nephrology. 2012; 27: 1041–1050.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Boor P, Ostendorf T, Floege J. PDGF and the progression of renal disease. Nephrology Dialysis Transplantation. 2014; 29 (Suppl 1): I45–I54.</mixed-citation><mixed-citation xml:lang="en">Boor P, Ostendorf T, Floege J. PDGF and the progression of renal disease. Nephrology Dialysis Transplantation. 2014; 29 (Suppl 1): I45–I54.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Ortiz A. PDGFR-β and kidney fibrosis. EMBO Mol Med. 2020; 12 (3): e11729. doi: 10.15252/emmm.201911729.</mixed-citation><mixed-citation xml:lang="en">Ortiz A. PDGFR-β and kidney fibrosis. EMBO Mol Med. 2020; 12 (3): e11729. doi: 10.15252/emmm.201911729.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Киселева ЕП, Крылов АВ, Старикова ЭА, Кузнецова СА. Фактор роста сосудистого эндотелия и иммунная система. Успехи современной биологии. 2009; 129 (4): 1–12.</mixed-citation><mixed-citation xml:lang="en">Kiseleva YeP, Krylov AV, Starikova EA, Kuznetsova SA. Faktor rosta sosudistogo endoteliya i immunnaya sistema. Uspekhi sovremennoy biologii. 2009; 129 (4): 1–12.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Taimeh Z, Loughran J, Birks EJ, Bolli R. Vascular endothelial growth factor in heart failure. Nature Reviews Cardiology. 2013; 10: 519–530.</mixed-citation><mixed-citation xml:lang="en">Taimeh Z, Loughran J, Birks EJ, Bolli R. Vascular endothelial growth factor in heart failure. Nature Reviews Cardiology. 2013; 10: 519–530.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Kinashi H, Ito Y, Sun T, Katsuno T, Takei Y. Roles of the TGF-β–VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis. Int J Mol Sci. 2018; 19 (9): 2487. doi: 10.3390/ijms19092487.</mixed-citation><mixed-citation xml:lang="en">Kinashi H, Ito Y, Sun T, Katsuno T, Takei Y. Roles of the TGF-β–VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis. Int J Mol Sci. 2018; 19 (9): 2487. doi: 10.3390/ijms19092487.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Zhang C, Li L, Liang X, Cheng P, Li Q et al. Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization. Cell Death Dis. 2021; 12 (1): 109. doi: 10.1038/s41419-020-03385-x.</mixed-citation><mixed-citation xml:lang="en">Zhang Y, Zhang C, Li L, Liang X, Cheng P, Li Q et al. Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization. Cell Death Dis. 2021; 12 (1): 109. doi: 10.1038/s41419-020-03385-x.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev. 2011; 91 (3): 827–887.</mixed-citation><mixed-citation xml:lang="en">Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev. 2011; 91 (3): 827–887.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Shevchenko O., Sharapchenko S., Gichkun O., Velikiy D., Tsirulnikova O., Gautier S. et al. Mir-339 and galectin-3: diagnostic value in patients with airway obstruction after lung transplantation. Transplant International. 2021; 3 (9): 1733–1739.</mixed-citation><mixed-citation xml:lang="en">Shevchenko O., Sharapchenko S., Gichkun O., Velikiy D., Tsirulnikova O., Gautier S. et al. Mir-339 and galectin-3: diagnostic value in patients with airway obstruction after lung transplantation. Transplant International. 2021; 3 (9): 1733–1739.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Perez-Carrillo L, Sanchez-Lazaro I, Trivino JC, Feijoo-Bandin S, Lago F, Gonzalez-Juanatey JR et al. Diagnostic value of serum miR-144-3p for the detection of acute cellular rejection in heart transplant patients. J Heart Lung Transplant. 2022; 41 (2): 137–147.</mixed-citation><mixed-citation xml:lang="en">Perez-Carrillo L, Sanchez-Lazaro I, Trivino JC, Feijoo-Bandin S, Lago F, Gonzalez-Juanatey JR et al. Diagnostic value of serum miR-144-3p for the detection of acute cellular rejection in heart transplant patients. J Heart Lung Transplant. 2022; 41 (2): 137–147.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Budding K, Rossato M, van de Graaf EA, Kwakkel-van Erp JM, Radstake TRDJ, Otten HG. Serum miRNAs as potential biomarkers for the bronchiolitis obliterans syndrome after lung transplantation. Transpl Immunol. 2017; 42: 1–4. doi: 10.1016/j.trim.2017.04.002.</mixed-citation><mixed-citation xml:lang="en">Budding K, Rossato M, van de Graaf EA, Kwakkel-van Erp JM, Radstake TRDJ, Otten HG. Serum miRNAs as potential biomarkers for the bronchiolitis obliterans syndrome after lung transplantation. Transpl Immunol. 2017; 42: 1–4. doi: 10.1016/j.trim.2017.04.002.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Liang J, Tang Y, Liu Z, Wang X, Tang L, Zou Z et al. Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model. Life Sci. 2019; 227: 51–57.</mixed-citation><mixed-citation xml:lang="en">Liang J, Tang Y, Liu Z, Wang X, Tang L, Zou Z et al. Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model. Life Sci. 2019; 227: 51–57.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S et al. Genome sequencing in the clinic: the past, present, and future of genomic medicine. Physiol Genomics. 2018; 50 (8): 563–579.</mixed-citation><mixed-citation xml:lang="en">Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S et al. Genome sequencing in the clinic: the past, present, and future of genomic medicine. Physiol Genomics. 2018; 50 (8): 563–579.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012; 4 (121): 121ra18. doi: 10.1126/scitranslmed.3003205.</mixed-citation><mixed-citation xml:lang="en">Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012; 4 (121): 121ra18. doi: 10.1126/scitranslmed.3003205.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Denby L, Ramdas V, Lu R, Conway BR, Grant JS, Dickinson B et al. MicroRNA-214 antagonism protects against renal fibrosis. J Am Soc Nephrol. 2014; 25 (1): 65–80.</mixed-citation><mixed-citation xml:lang="en">Denby L, Ramdas V, Lu R, Conway BR, Grant JS, Dickinson B et al. MicroRNA-214 antagonism protects against renal fibrosis. J Am Soc Nephrol. 2014; 25 (1): 65–80.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Chung AC, Huang XR, Meng X, Lan HY. MiR-192 mediates TGFbeta/Smad3-driven renal fibrosis. Journal of the American Society of Nephrology. 2010; 21: 1317–1325.</mixed-citation><mixed-citation xml:lang="en">Chung AC, Huang XR, Meng X, Lan HY. MiR-192 mediates TGFbeta/Smad3-driven renal fibrosis. Journal of the American Society of Nephrology. 2010; 21: 1317–1325.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Wang B, Komers R, Carew R, Winbanks CE, Xu B, Herman-Edelstein M et al. Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis. J Am Soc Nephrol. 2012; 23 (2): 252–265.</mixed-citation><mixed-citation xml:lang="en">Wang B, Komers R, Carew R, Winbanks CE, Xu B, Herman-Edelstein M et al. Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis. J Am Soc Nephrol. 2012; 23 (2): 252–265.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Oba S, Kumano S, Suzuki E, Nishimatsu H, Takahashi M, Takamori H et al. miR-200b precursor can ameliorate renal tubulointerstitial fibrosis. PLoS One. 2010; 5 (10): e13614. doi: 10.1371/journal.pone.0013614.</mixed-citation><mixed-citation xml:lang="en">Oba S, Kumano S, Suzuki E, Nishimatsu H, Takahashi M, Takamori H et al. miR-200b precursor can ameliorate renal tubulointerstitial fibrosis. PLoS One. 2010; 5 (10): e13614. doi: 10.1371/journal.pone.0013614.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang L, Qiu W, Zhou Y, Wen P, Fang L, Cao H et al. A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. Kidney Int. 2013; 84 (2): 285–296.</mixed-citation><mixed-citation xml:lang="en">Jiang L, Qiu W, Zhou Y, Wen P, Fang L, Cao H et al. A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. Kidney Int. 2013; 84 (2): 285–296.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Li R, Chung AC, Dong Y, Yang W, Zhong X, Lan HY. The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway. Kidney Int. 2013; 84 (6): 1129–1144.</mixed-citation><mixed-citation xml:lang="en">Li R, Chung AC, Dong Y, Yang W, Zhong X, Lan HY. The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway. Kidney Int. 2013; 84 (6): 1129–1144.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
