vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2009-2-6-15vtio-153Research ArticleКлиническая трансплантологияClinical TransplantologyВЛИЯНИЕ ПОСТТРАНСПЛАНТАЦИОННЫХ ФАКТОРОВ НА ДЛИТЕЛЬНОСТЬ ВЫЖИВАНИЯ РЕЦИПИЕНТОВ ПОСЛЕ ТРАНСПЛАНТАЦИИ СЕРДЦАTHE INFLUENCE OF POSTTRANSPLANT FACTORS ON THE LONG-TERM SURVIVAL AFTER HEART TRANSPLANTATIONЗахаревичВ.М.ZakharevichV.M.1@ru.ruФГУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздравсоцразвития РФ, МоскваРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs, MoscowRussian Federation200923092009112615Copyright © Захаревич В., 20092009Захаревич В.Zakharevich V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/153

В настоящее исследование включен 71 пациент – 61 мужчина и 10 женщин, которым в период с 1987-го по 2006 г. в НИИТиИО выполнена ортотопическая трансплантация сердца. Возраст пациентов на момент выполнения операции составлял от 14 до 57 лет (средний возраст 34,5 года). В исследование включены только реципиенты сердца, выписанные из стационара. Для оценки влияния на выживаемость указанных факторов был использован пакет статистических методов, включавший сравнительный анализ актуриальной выживаемости, анализ относительных рисков и отношения шансов, пропорциональный регрессионный анализ Кокса. Среди посттрансплантационных факторов, включенных в анализ, болезнь коронарных артерий пересаженного сердца идентифицирована как предиктор риска, достоверно ухудшающий прогноз отдаленной выживаемости. Наличие типов В1, В2 и С артериопатии трансплантата является особенно неблагоприятным фактором прогноза. Проведение чрескожного коронарного вмешательства у больных с типом поражения А достоверно улучшает актуриальную выживаемость по сравнению с больными с дистальным поражением (тип В1, В2 и С), которым не могло быть выполнено чрескожное вмешательство.

In this study 71 patients (61 male and 10 female) were included, who have been operated in our institute from 1987 to 2006. All of them were undergoing orthotopic heart transplantation. The age of patients was from 14 to 57 years (the mean age 34,5). Only patients who were discharged from the hospital were included in the study. For statistical analysis Kaplan-Mayer survival analysis, relative risks (RR) and ODDR, proportional hazard risks regression of Cox were used. Coronary arteries disease was identifi ed as risk factor for long-term survival prognosis. Types B1, B2 and C arteriopathy are very unfavorable for long-term survival prognosis.

Percutaneus coronary intervention for type A improves long-term survival prognosis in comparison with types B and C.

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The authors declare that there are no conflicts of interest present.