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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2022-3-42-50</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1514</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая трансплантология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Transplantology</subject></subj-group></article-categories><title-group><article-title>Использование эндоскопического лигирования варикозных узлов в комбинации с неселективными β-блокаторами, или самостоятельно, в профилактике кровотечений у больных с асцитом, включенных в лист ожидания трансплантации печени</article-title><trans-title-group xml:lang="en"><trans-title>Use of endoscopic band ligation alone and in combination with nonselective beta blockers for prevention of variceal bleeding in ascites patients on the liver transplant waiting list</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коробка</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Korobka</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пасечников</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Pasetchnikov</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пасечников Виктор Дмитриевич</p><p>Адрес: 355017, Ставрополь, ул. Авиационная, 21Тел. (962) 447-75-13</p></bio><bio xml:lang="en"><p>Victor Pasetchnikov</p><p>Address: 21, Aviatsionnaya str., Stavropol, 355017Phone: (962) 447-75-13</p></bio><email xlink:type="simple">passetchnikov@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коробка</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korobka</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пак</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pak</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаповалов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapovalov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ Ростовской области «Ростовская областная клиническая больница»; ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Regional Clinical Hospital; Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУ Ростовской области «Ростовская областная клиническая больница»; ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Regional Clinical Hospital; Stavropol State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУ Ростовской области «Ростовская областная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>23</day><month>08</month><year>2022</year></pub-date><volume>24</volume><issue>3</issue><fpage>42</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коробка В.Л., Пасечников В.Д., Коробка Р.В., Пак Е.С., Шаповалов А.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Коробка В.Л., Пасечников В.Д., Коробка Р.В., Пак Е.С., Шаповалов А.М.</copyright-holder><copyright-holder xml:lang="en">Korobka V.L., Pasetchnikov V.D., Korobka R.V., Pak E.S., Shapovalov A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1514">https://journal.transpl.ru/vtio/article/view/1514</self-uri><abstract><p>Цель: проведение сравнительного анализа эффективности двух методов: ЭЛВУ и ЭЛВУ в комбина- ции с НСББ, используемых в целях профилактики кровотечений из ВУ, оценка их влияния на показа- тели выживаемости пациентов с выраженным асцитом в период долгосрочного пребывания в ЛОТП. Материалы и методы. Проведено ретроспективное сравнительное исследование двух групп пациентов с декомпенсированными заболеваниями печени, наличием асцита и ВУ, включенных в ЛОТП, получавших ЭЛВУ (n = 41, первая группа) и комбинацию ЭЛВУ и НСББ (n = 45, вторая группа). Результаты. Сравниваемые группы не различались по демографическим, клиническим параметрам, показателям MELD и классов Child–Turcotte–Pugh. Не было отмечено значимых различий в частоте выраженного асцита, и в частности асцита, резистентного к диуретикам. Исследуемые группы пациентов не различались по частоте варикозных узлов среднего и большого размера. Частота развития кровотечений не различалась в обеих сравниваемых группах. Общая летальность в группе больных, получавших ЭЛВУ + НСББ, была значимо выше, чем в группе ЭЛВУ. Выживаемость пациентов была ниже, а риск развития смертельного исхода – выше у пациентов в группе ЭЛВУ + НСББ. В группе, получавшей комбинированную терапию, обнаруживалось значимо большее количество ОПП, чем в группе, получавшей только эндоскопическое лечение. Заключение. Сравниваемые методы обладают одинаковой эффективностью в предупреждении кровотечений из ВУ у больных с декомпенсированным циррозом при долгосрочном пребывании в листе ожидания. Выживаемость значимо ниже, а летальность значимо выше в группе пациентов, получавших комбинацию ЭЛВУ и НСББ, чем в группе пациентов, подвергшихся только ЭЛВУ.</p></abstract><trans-abstract xml:lang="en"><p>Objective: to conduct a comparative analysis of the effectiveness of two methods – endoscopic band ligation (EBL) alone and in combination with nonselective beta blockers (NSBB) – used for prevention of variceal bleeding (VB); to evaluate their impact on patient survival in severe ascites during long-term stay on the liver transplant waiting list (LTWL). Materials and methods. A retrospective comparative study of two groups of patients with decompensated liver disease, ascites and varices included in the LTWL, who received EBL (n = 41, group 1) and EBL + NSBB (n = 45, group 2). Results. The groups being compared did not differ in demographics, clinical parameters, MELD and Child–Turcotte–Pugh scores. There were no significant differences in the incidence of severe ascites, particularly diuretic-resistant ascites. The study groups did not differ in the incidence of mediumand large-sized varices. Incidence of bleeding did not differ in both groups. Overall mortality was significantly higher in the EBL + NSBB group than in the EBL group. Patient survival was lower, while mortality was higher in the EBL + NSBB group. The combined therapy group had a significantly higher number of acute kidney injury (AKI) than the EBL group. Conclusion. The compared methods are equivalently effective in preventing VB in patients with decompensated cirrhosis with a prolonged stay on the waiting list. Survival rate is significantly lower, while mortality is significantly higher in the EBL + NSBB group than in the EBL group.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лист ожидания трансплантации печени</kwd><kwd>асцит</kwd><kwd>кровотечения</kwd><kwd>неселективные β-блокаторы</kwd><kwd>эндоскопическое лигирование варикозных узлов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver transplant waiting list</kwd><kwd>ascites</kwd><kwd>bleeding</kwd><kwd>nonselective beta blockers</kwd><kwd>endoscopic band ligation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lee J, Lee JG, Jung I, Joo DJ, Kim SI, Kim MS. Advisory Committee on Improving Liver Allocation. 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