vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2022-2-65-70vtio-1501Research ArticleТрансплантомикаTransplantomicsВлияние системы гормона роста / ИФР-1 на функцию трансплантата и иммунный ответ у детей – реципиентов печениImpact of the growth hormone and IGF-1 on graft function and immune response in pediatric liver recipientsКурабековаР. М.KurabekovaR. M.

Курабекова Ривада Мусабековна

123182, Москва, ул. Щукинская, д. 1Тел. (499) 190-53-44

Rivada Kurabekova

1, Shchukinskaya str., Moscow, 123182Phone: (499) 190-53-44

transplant2009@mail.ruЦирульниковаО. М.TsirulnikovaO. M.

Москва

Moscow

tsiroulnikova@mail.ruОлешкевичС. Ю.OleshkevichS. Yu.

Москва

Moscow

prockuratova.sonechka@gmail.comПашковаИ. Е.PashkovaI. E.

Москва

Moscow

irish7@inbox.ruОлефиренкоГ. А.OlefirenkoG. A.

Москва

Moscow

olefirenkoga@mail.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityRussian Federation2022040520222426570Copyright © Курабекова Р.М., Цирульникова О.М., Олешкевич С.Ю., Пашкова И.Е., Олефиренко Г.А., 20222022Курабекова Р.М., Цирульникова О.М., Олешкевич С.Ю., Пашкова И.Е., Олефиренко Г.А.Kurabekova R.M., Tsirulnikova O.M., Oleshkevich S.Y., Pashkova I.E., Olefirenko G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1501

Гормон роста (ГР) и инсулиноподобный фактор роста 1 (ИФР-1) – важнейшие регуляторы роста, регенерации и метаболизма. Влияние гормона роста и ИФР-1 на результаты трансплантации печени детям опосредовано через регуляцию роста и массы тела, специфические эффекты на функцию гепатоцитов, активность иммунной системы. Последние годы показана связь содержания этих факторов в крови с продолжительностью жизни, как здоровых лиц, так и реципиентов печени. У детей – реципиентов печени нейрогуморальная регуляция функции трансплантата, как и других функций растущего организма, исследованы недостаточно. Результаты исследований содержания и динамики гормона роста и ИФР-1 в крови у реципиентов печени могут служить основой для оценки состояния трансплантата с помощью новых малоинвазивных методов и выявления терапевтических мишеней для персонифицированной терапии. В настоящем обзоре суммированы современные представления о значении гормонов системы ГР/ИФР-1 при заболеваниях гепатобилиарной системы и трансплантации печени детям.

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are the most important regulators of growth, regeneration and metabolism. The influence of GH and IGF-1 on pediatric liver transplant outcomes is mediated through growth and body weight regulation, specific effects on hepatocyte function and immune system activity. In recent years, the blood levels of these factors and life expectancy, both in healthy individuals and liver recipients, have been shown to be correlated. In pediatric liver recipients, neurohumoral regulation of graft function and other functions of the growing organism, has not been studied enough. The results of studies on the levels and dynamics of GH and IGF-1 in the blood of liver recipients can serve as a basis for assessing the state of graft using new minimally invasive methods and identifying therapeutic targets for personalized therapy. This review summarizes the current understanding of the significance of GH/IGF-1 hormones in hepatobiliary diseases and pediatric liver transplantation (LTx).

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The authors declare that there are no conflicts of interest present.