vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2022-2-51-57vtio-1484Research ArticleТрансплантация сердца и вспомогательное кровообращениеHeart Transplantation and Assisted CirculationРоль синдрома физического истощения (frailty) при отборе пациентов на трансплантацию сердцаThe role of frailty in selecting patients for heart transplantationКолосковаН. Н.KoloskovaN. N.

Колоскова Надежда Николаевна

123182, Москва, ул. Щукинская, д. 1Тел. (926) 651-40-64

Nadezhda Koloskova

1, Shchukinskaya str., Moscow, 123182Phone: (926) 651-40-64

nkrasotka@mail.ruШевченкоА. О.ShevchenkoA. O.

Москва

Moscow

alxxshevchenko@aol.comФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет); ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University; Pirogov Russian National Research Medical UniversityRussian Federation2022250420222425157Copyright © Колоскова Н.Н., Шевченко А.О., 20222022Колоскова Н.Н., Шевченко А.О.Koloskova N.N., Shevchenko A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1484

Роль синдрома физического истощения при сердечно-сосудистых заболеваниях становится все более очевидной. У пациентов с хронической сердечной недостаточностью данный синдром диагностируется примерно в 79% случаев, а наличие данного синдрома связано со снижением качества жизни и неблагоприятным прогнозом выживаемости. В этом обзоре обобщена доступная литература, касающаяся синдрома физического истощения, а также его значение при отборе пациентов на трансплантацию сердца.

The role of frailty in cardiovascular disease is becoming increasingly recognized. Up to 79% of patients with heart failure are frail. Frailty is associated with reduced quality of life and poor prognosis. This review summarizes the available literature on frailty and its key role in waitlisting patients for heart transplantation.

сердечная недостаточностьтрансплантация сердцасиндром общей слабостиheart failureheart transplantationfrailtyReferencesMehra MR, Canter CE, Hannan MM, Semigran MJ, Uber PA, Baran DA et al. The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant. 2016; 35: 1–23.Mehra MR, Canter CE, Hannan MM, Semigran MJ, Uber PA, Baran DA et al. The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant. 2016; 35: 1–23.Daneshvar DA, Czer LS, Phan A, Trento A, Schwarz ER. Heart transplantation in the elderly: why cardiac transplantation does not need to be limited to younger patients but can be safely performed in patients above 65 years of age. Ann Transplant. 2010; 15: 110–119.Daneshvar DA, Czer LS, Phan A, Trento A, Schwarz ER. Heart transplantation in the elderly: why cardiac transplantation does not need to be limited to younger patients but can be safely performed in patients above 65 years of age. Ann Transplant. 2010; 15: 110–119.Мареев ВЮ, Агеев ФТ, Арутюнов ГП и др. Национальные рекомендации ОССН, РКО и РНМОТ по диагностике и лечению ХСН (четвертый пересмотр). Распространенность хронической сердечной недостаточности в Европейской части Российской Федерации – данные ЭПОХА-ХСН. Сердечная недостаточность. 2006; 7 (1): 112–115.Mareev VYu, Ageev FT, Arutyunov GP i dr. Natsional’nye rekomendatsii OSSN, RKO i RNMOT po diagnostike i lecheniyu KhSN (chetvertyy peresmotr). Rasprostranennost’ khronicheskoy serdechnoy nedostatochnosti v Evropeyskoy chasti Rossiyskoy Federatsii – dannye EPOKhA-KhSN. Serdechnaya nedostatochnost’. 2006; 7 (1): 112–115.Колоскова НН. Медикаментозная терапия у реципиентов трансплантированного сердца: дис. … д-ра мед. наук. М., 2020. 212.Koloskova NN. Medikamentoznaya terapiya u retsipientov transplantirovannogo serdtsa: dis. … d-ra med. nauk. M., 2020. 212.Попцов ВН, Золотова ЕН. Трансплантация сердца у реципиентов с сахарным диабетом. Вестник трансплантологии и искусственных органов. 2018; XX (1): 120–126.Poptsov VN, Zolotova EN. Transplantatsiya serdtsa u retsipientov s sakharnym diabetom. Vestnik transplantologii i iskusstvennykh organov. 2018; XX(1): 120–126.Xue Q-L. The Frailty Syndrome: Definition and Natural History. Clin Geriatr Med. 2011; 27 (1): 1–15.Xue Q-L. The Frailty Syndrome: Definition and Natural History. Clin Geriatr Med. 2011; 27 (1): 1–15.Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013; 381: 752–762.Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013; 381: 752–762.Kobashigawa J, Dadhania D, Bhorade S, Adey D, Berger J, Bhat G et al. Report from the American Society of Transplantation on frailty in solid organ transplantation. Am J Transplant. 2019; 19 (4): 984–994.Kobashigawa J, Dadhania D, Bhorade S, Adey D, Berger J, Bhat G et al. Report from the American Society of Transplantation on frailty in solid organ transplantation. Am J Transplant. 2019; 19 (4): 984–994.Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell. 2017; 16 (3): 444–450.Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell. 2017; 16 (3): 444–450.Wang J, Maxwell CA, Yu F. Biological Processes and Biomarkers Related to Frailty in Older Adults: A Stateof-the-Science Literature Review. Biol Res Nurs. 2018; 21: 80–106.Wang J, Maxwell CA, Yu F. Biological Processes and Biomarkers Related to Frailty in Older Adults: A Stateof-the-Science Literature Review. Biol Res Nurs. 2018; 21: 80–106.Yao X, Li H, Leng SX. Inflammation and Immune System Alterations in Frailty. Clin Geriatr Med. 2011; 27 (1): 79–87.Yao X, Li H, Leng SX. Inflammation and Immune System Alterations in Frailty. Clin Geriatr Med. 2011; 27 (1): 79–87.Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nature Aging. 2021; 1: 36–46.Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nature Aging. 2021; 1: 36–46.Ng TP, Lu Y, Choo RWM, Tan CTY, Nyunt MSZ, Gao Q et al. Dysregulated homeostatic pathways in sarcopenia among frailolder adults. Aging Cell. 2018; 17: e12842.Ng TP, Lu Y, Choo RWM, Tan CTY, Nyunt MSZ, Gao Q et al. Dysregulated homeostatic pathways in sarcopenia among frailolder adults. Aging Cell. 2018; 17: e12842.Jha SR, Hannu MK, Gore K, Chang S, Newton P, Wilhelm K et al. Cognitive impairment improves the predictive validity of physical frailty for mortality in patients with advanced heart failure referred for heart transplantation. J Heart Lung Transplant. 2016; 35: 1092–1100.Jha SR, Hannu MK, Gore K, Chang S, Newton P, Wilhelm K et al. Cognitive impairment improves the predictive validity of physical frailty for mortality in patients with advanced heart failure referred for heart transplantation. J Heart Lung Transplant. 2016; 35: 1092–1100.Wilson ME, Vakil AP, Kandel P, Undavalli C, Dunlay SM, Kennedy CC. Pretransplant frailty is associated with decreased survival after lung transplantation. J Heart Lung Transplant. 2016; 35 (2): 173–178.Wilson ME, Vakil AP, Kandel P, Undavalli C, Dunlay SM, Kennedy CC. Pretransplant frailty is associated with decreased survival after lung transplantation. J Heart Lung Transplant. 2016; 35 (2): 173–178.Готье СВ. Иммуносупрессия при трансплантации солидных органов. М.: Триада, 2011: 200–205.Gautier SV. Immunosupressiya pri transplantatsii solidnykh organov. M.: Triada, 2011: 200–205.Wilson D, Jackson T, Sapey E, Lord JM. Frailty and Sarcopenia: The potential role of an aged immune system. Ageing Res Rev. 2017; 36: 1–10.Wilson D, Jackson T, Sapey E, Lord JM. Frailty and Sarcopenia: The potential role of an aged immune system. Ageing Res Rev. 2017; 36: 1–10.Goldwater D, Altman NL. Frailty and heart failure. American College of Cardiology, 5 August 2016. https://www.acc.org/latest-in-cardiology/articles/2016/08/05/08/40/frailty-and-heart-failure/.Goldwater D, Altman NL. Frailty and heart failure. American College of Cardiology, 5 August 2016. https://www.acc.org/latest-in-cardiology/articles/2016/08/05/08/40/frailty-and-heart-failure/.Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56 (3): 146–156.Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56 (3): 146–156.Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA et al. The Cardiovascular Health Study: design and rationale. Epidemiol. 1991; 1 (3): 263–276.Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA et al. The Cardiovascular Health Study: design and rationale. Epidemiol. 1991; 1 (3): 263–276.Gorodeski EZ, Goyal P, Hummel SL, Krishnaswami A, Goodlin SJ, Hart LL et al. Domain management approach to heart failure in the geriatric patient: present and future. J Am Coll Cardiol. 2018; 71: 1921–1936.Gorodeski EZ, Goyal P, Hummel SL, Krishnaswami A, Goodlin SJ, Hart LL et al. Domain management approach to heart failure in the geriatric patient: present and future. J Am Coll Cardiol. 2018; 71: 1921–1936.Rodríguez-Pascual C, Paredes-Galán E, Ferrero-Martínez AI, Gonzalez-Guerrero JL, Hornillos-Calvo M, Menendez-Colino R et al. The frailty syndrome is associated with adverse health outcomes in very old patients with stable heart failure: A prospective study in six Spanish hospitals. Int J Cardiol. 2017 Jun 1; 236: 296–303.Rodríguez-Pascual C, Paredes-Galán E, Ferrero-Martínez AI, Gonzalez-Guerrero JL, Hornillos-Calvo M, Menendez-Colino R et al. The frailty syndrome is associated with adverse health outcomes in very old patients with stable heart failure: A prospective study in six Spanish hospitals. Int J Cardiol. 2017 Jun 1; 236: 296–303.Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009 Jun 1; 103 (11):1616–1621.Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009 Jun 1; 103 (11):1616–1621.Butrous H, Hummel SL. Heart Failure in Older Adults. Can J Cardiol. 2016 Sep; 32 (9): 1140–1147.Butrous H, Hummel SL. Heart Failure in Older Adults. Can J Cardiol. 2016 Sep; 32 (9): 1140–1147.Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007; 62: 722–727.Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007; 62: 722–727.Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994; 49: 85–94.Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994; 49: 85–94.Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995; 332: 556–561.Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995; 332: 556–561.Lupón J, González B, Santaeugenia S, Altimir S, Urrutia A, Más D et al. Prognostic implication of frailty and depressive symptoms in an outpatient population with heart failure. Rev Esp Cardiol. 2008; 61: 835–842.Lupón J, González B, Santaeugenia S, Altimir S, Urrutia A, Más D et al. Prognostic implication of frailty and depressive symptoms in an outpatient population with heart failure. Rev Esp Cardiol. 2008; 61: 835–842.Khan H, Kalogeropoulos AP, Georgiopoulou VV, Newman AB, Harris TB, Rodondi N et al. Frailty and risk for heart failure in older adults: the health, aging, and body composition study. Am Heart J. 2013; 166: 887–894.Khan H, Kalogeropoulos AP, Georgiopoulou VV, Newman AB, Harris TB, Rodondi N et al. Frailty and risk for heart failure in older adults: the health, aging, and body composition study. Am Heart J. 2013; 166: 887–894.Pandey A, Kitzman D, Reeves G. Frailty Is Intertwined With Heart Failure: Mechanisms, Prevalence, Prognosis, Assessment, and Management. JACC Heart Fail. 2019; 7 (12): 1001–1011.Pandey A, Kitzman D, Reeves G. Frailty Is Intertwined With Heart Failure: Mechanisms, Prevalence, Prognosis, Assessment, and Management. JACC Heart Fail. 2019; 7 (12): 1001–1011.Vidán MT, Blaya-Novakova V, Sánchez E, Ortiz J, SerraRexach JA, Bueno H. Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure. Eur J Heart Fail. 2016; 18(7): 869–875.Vidán MT, Blaya-Novakova V, Sánchez E, Ortiz J, SerraRexach JA, Bueno H. Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure. Eur J Heart Fail. 2016; 18(7): 869–875.Volpato S, Cavalieri M, Guerra G, Sioulis F, Ranzini M, Maraldi C et al. Performance-based functional assessment in older hospitalized patients: feasibility and clinical correlates. J Gerontol A Biol Sci Med Sci. 2008; 63: 1393–1398.Volpato S, Cavalieri M, Guerra G, Sioulis F, Ranzini M, Maraldi C et al. Performance-based functional assessment in older hospitalized patients: feasibility and clinical correlates. J Gerontol A Biol Sci Med Sci. 2008; 63: 1393–1398.Vitale C, Uchmanowicz I. Frailty in patients with heart failure. Eur Heart J Suppl. 2019; 21: 12–16.Vitale C, Uchmanowicz I. Frailty in patients with heart failure. Eur Heart J Suppl. 2019; 21: 12–16.Jha SR, Hannu MK, Chang S, Montgomery E, Harkess M, Wilhelm K et al. The Prevalence and Prognostic Significance of Frailty in Patients With Advanced Heart Failure Referred for Heart Transplantation. Transplantation. 2016; 100 (2): 429–436.Jha SR, Hannu MK, Chang S, Montgomery E, Harkess M, Wilhelm K et al. The Prevalence and Prognostic Significance of Frailty in Patients With Advanced Heart Failure Referred for Heart Transplantation. Transplantation. 2016; 100 (2): 429–436.Dunlay SM, Park SJ, Joyce LD, Daly RC, Stulak JM, McNallan SM et al. Frailty and outcomes after implantation of left ventricular assist device as destination therapy. J Heart Lung Transplant. 2014; 33 (4): 359–365.Dunlay SM, Park SJ, Joyce LD, Daly RC, Stulak JM, McNallan SM et al. Frailty and outcomes after implantation of left ventricular assist device as destination therapy. J Heart Lung Transplant. 2014; 33 (4): 359–365.Jha SR, Hannu MK, Newton PJ, Wilhelm K, Hayward CS, Jabbour A et al. Reversibility of Frailty After Bridge-to-Transplant Ventricular Assist Device Implantation or Heart Transplantation. Transplant Direct. 2017 May 30; 3 (7): e167.Jha SR, Hannu MK, Newton PJ, Wilhelm K, Hayward CS, Jabbour A et al. Reversibility of Frailty After Bridge-to-Transplant Ventricular Assist Device Implantation or Heart Transplantation. Transplant Direct. 2017 May 30; 3 (7): e167.Macdonald PS, Gorrie N, Brennan X, Aili SR, De Silva R, Jha SR et al. The impact of frailty on mortality after heart transplantation. J Heart Lung Transplant. 2021; 40: 87–94.Macdonald PS, Gorrie N, Brennan X, Aili SR, De Silva R, Jha SR et al. The impact of frailty on mortality after heart transplantation. J Heart Lung Transplant. 2021; 40: 87–94.McAdams-DeMarco MA, Olorundare IO, Ying H, Warsame F, Haugen CE, Hall R et al. Frailty and postkidney transplant health-related quality of life. Transplantation. 2018; 102: 291–299.McAdams-DeMarco MA, Olorundare IO, Ying H, Warsame F, Haugen CE, Hall R et al. Frailty and postkidney transplant health-related quality of life. Transplantation. 2018; 102: 291–299.Flint KM, Matlock DD, Lindenfeld J, Allen LA. Frailty and the selection of patients for destination therapy left ventricular assist device. Circ Heart Fail. 2012; 5: 286–293.Flint KM, Matlock DD, Lindenfeld J, Allen LA. Frailty and the selection of patients for destination therapy left ventricular assist device. Circ Heart Fail. 2012; 5: 286–293.Maurer MS, Horn E, Reyentovich A, Dickson VV, Pinney S, Goldwater D et al. Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty? J Am Geriatr Soc. 2017; 65: 2383–2390.Maurer MS, Horn E, Reyentovich A, Dickson VV, Pinney S, Goldwater D et al. Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty? J Am Geriatr Soc. 2017; 65: 2383–2390.Jha S, Newton P, Montgomery E, Hayward C, Jabbour A, Muthiah K et al. Frailty Predicts Mortality after Heart Transplantation. Transplantation. 2018; 102: S62.Jha S, Newton P, Montgomery E, Hayward C, Jabbour A, Muthiah K et al. Frailty Predicts Mortality after Heart Transplantation. Transplantation. 2018; 102: S62.Flint KM, Matlock DD, Lindenfeld J, Allen LA. Frailty and the Selection of Patients for Destination Therapy Left Ventricular Assist Device. Circ Heart Fail. 2012; 5: 286–293.Flint KM, Matlock DD, Lindenfeld J, Allen LA. Frailty and the Selection of Patients for Destination Therapy Left Ventricular Assist Device. Circ Heart Fail. 2012; 5: 286–293.Kobashigawa J, Dadhania D, Bhorade S, Adey D, Berger J, Bhat G et al. Report from the American Society of Transplantation on frailty in solid organ transplantation. Am J Transplant. 2019; 19: 984–994.Kobashigawa J, Dadhania D, Bhorade S, Adey D, Berger J, Bhat G et al. Report from the American Society of Transplantation on frailty in solid organ transplantation. Am J Transplant. 2019; 19: 984–994.

The authors declare that there are no conflicts of interest present.