vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2013-1-89-95vtio-145Research ArticleКлинические наблюденияClinical CasesЦЕНТРАЛЬНЫЙ ПОНТИННЫЙ МИЕЛИНОЛИЗ ПОСЛЕ ОРТОТОПИЧЕСКОЙ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ (ДВА СЛУЧАЯ ИЗ ПРАКТИКИ)CENTRAL PONTINE MYELINOLYSIS AFTER ORTHOTOPIC LIVER TRANSPLANTATION (TWO CASE REPORTS)ДзядзькоА. М.DzyadzkoA. M.КатинМ. Л.KatinM. L.РуммоО. О.RummoO. O.ЩербаА. Е.ShcherbaA. E.СантоцкийЕ. О.SantotskyE. O.МиновА. Ф.MinovA. F.ГуроваМ. Ю.GurovaM. Y.ЧугуноваО. А.ChugunovaO. A.СлободинЮ. В.SlobodinY. V.ЗубрицкийС. М.ZubritskyS. M.АвдейЛ. Л.AvdeiL. L.РНПЦ трансплантации органов и тканей УЗ «9-я городская клиническая больница»Republican Research and Practice Centre «Tissue and Organ Transplantation», Minsk State Clinical Hospital No 9, Minsk, Republic of BelarusУЗ «Минский городской диагностический центр», г. Минск, Республика БеларусьMinsk Consulting and Diagnostic Center, Minsk, Republic of Belarus201327052014151ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XV No 1–20138995Copyright © Дзядзько А.М., Катин М.Л., Руммо О.О., Щерба А.Е., Сантоцкий Е.О., Минов А.Ф., Гурова М.Ю., Чугунова О.А., Слободин Ю.В., Зубрицкий С.М., Авдей Л.Л., 20132013Дзядзько А.М., Катин М.Л., Руммо О.О., Щерба А.Е., Сантоцкий Е.О., Минов А.Ф., Гурова М.Ю., Чугунова О.А., Слободин Ю.В., Зубрицкий С.М., Авдей Л.Л.Dzyadzko A.M., Katin M.L., Rummo O.O., Shcherba A.E., Santotsky E.O., Minov A.F., Gurova M.Y., Chugunova O.A., Slobodin Y.V., Zubritsky S.M., Avdei L.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/145

Центральный понтинный миелинолиз (ЦПМ) – редкое, но крайне тяжелое осложнение после ортото- пической трансплантации печени. Причина ЦПМ до настоящего времени точно не определена. Тем не менее быстрая коррекция гипонатриемии рассматривается как основной этиологический фактор. В на- стоящей статье нами представлены два клинических случая ЦПМ у пациентов, подвергшихся ортотопи- ческой трансплантации печени. Мы также обсуждаем патофизиологию, эпидемиологию, клиническую картину, способы лечения и меры профилактики ЦПМ. 

Central pontine myelinolysis (CPM) is the rare, but extremely severe complication after orthotopic liver trans- plantation. The reason for CPM is currently not precisely defined. However, the rapid correction of hyponatremia is considered as the main etiological factor. In this paper we present two clinical cases of CPM in patients under- went orthotopic liver transplantation. We also discuss the pathophysiology, epidemiology, clinical presentation, treatment options and preventive measures of CPM. 

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The authors declare that there are no conflicts of interest present.