References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2022-1-96-106

vtio-1448

Research Article

Регенеративная медицина и клеточные технологии

Regenerative Medicine and Cell Technologies

Структурная дегенерация биологических протезов клапанов сердца: имеются ли общие механизмы с атеросклерозом и кальцинирующим аортальным стенозом?

Structural valve degeneration: are there common mechanisms with atherosclerosis and calcific aortic stenosis?

Костюнин

А. Е.

Kostyunin

A. E.

Костюнин Александр Евгеньевич

Адрес: 650002, Кемерово, Сосновый бульвар, 6.

Тел. (900) 108-10-97

Alexander Kostyunin

6, Sosnovy Boulevard, Kemerovo, 650002

Phone: (900) 108-10-97

Rhabdophis_tigrina@mail.ru

ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation

2022

09022022

24196106

2022

Костюнин А.Е.

Kostyunin A.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/1448

Современные исследования показывают, что некоторые из патогенетических процессов, стоящих за структурным разрушением биопротезов клапанов сердца, в значительной мере сходны с таковыми, задействованными при развитии атеросклеротических поражений сосудов и кальцификации нативных клапанов. К их числу относится липидная и лейкоцитарная инфильтрация, характерная как для протезных, так и для нативных тканей. Эти процессы сопровождаются формированием пенистых клеток, избыточной продукцией матрикс-разрушающих ферментов и усилением окислительного стресса. Данный факт позволяет выдвинуть предположение, что некоторые подходы консервативной терапии атеросклероза могут быть полезны для продления сроков функционирования биопротезов клапанов.

Current research shows that some of the pathogenetic processes behind structural destruction of bioprosthetic valves are largely similar to those involved in the development of atherosclerotic vascular lesions and native valve calcification. These processes include lipid and leukocyte infiltration, typical for both prosthetic and native tissues. They are accompanied by formation of foam cells, excessive production of matrix-degrading enzymes and increased oxidative stress. This fact suggests that some approaches to conservative treatment of atherosclerosis may be useful for prolonging the lifespan of bioprosthetic valves.

биопротезы клапанов сердцаструктурная дегенерация клапанаатеросклерозкальцинирующий аортальный стенозконсервативная терапияпатофизиологияфакторы риска

bioprosthetic heart valvesstructural valve degenerationatherosclerosiscalcific aortic stenosisconservative therapypathophysiologyrisk factors

Настоящая работа выполнена в рамках комплексной программы фундаментальных научных исследований по фундаментальной теме НИИ КПССЗ№ 0546-2015-0011 «Патогенетическое обоснование разработки имплантатов для сердечно-сосудистой хирургии на основе биосовместимых материалов с реализацией пациент-ориентированного подхода с использованием математического моделирования, тканевой инженерии и геномных предикторов».

Research Institute for Complex Issues of Cardiovascular Diseases, 650002, 6 Sosnovy Boulevard, Kemerovo, Russian Federation.

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The authors declare that there are no conflicts of interest present.