vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2021-4-73-78vtio-1423Research ArticleТрансплантация сердца и вспомогательное кровообращениеHeart Transplantation and Assisted CirculationОценка эффективности новой системы генерации пульсирующего потока в роторных насосах вспомогательного кровообращения. Исследование на математической моделиEvaluation of the efficiency of a new pulsatile flow‑generating circulatory-assist system in rotary blood pumps. Research on a mathematical modelИткинГ. П.ItkinG. P.

Иткин Георгий Пинкусович

123182, Москва, ул. Щукинская, д. 1

Тел (916) 129-78-33

George Itkin

1, Shchukinskaya str., Moscow, 123182, Russian Federation

Phone: (916) 129-78-33

georgeitkin@mail.ruСырбуА. И.SyrbuA. I.

Москва

Moscow

КулешовА. П.KyleshovA. P.

Москва

Moscow

БучневА. С.BuchnevA. S.

Москва

Moscow

ДробышевА. А.DrobyshevA. A.

Москва

Moscow

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Московский физико-технический институт (национальный исследовательский университет)»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Moscow Institute of Physics and TechnologyRussian FederationФГАОУ ВО «Московский физико-технический институт (национальный исследовательский университет)»РоссияMoscow Institute of Physics and TechnologyRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian Federation2021121120212347378Copyright © Иткин Г.П., Сырбу А.И., Кулешов А.П., Бучнев А.С., Дробышев А.А., 20222022Иткин Г.П., Сырбу А.И., Кулешов А.П., Бучнев А.С., Дробышев А.А.Itkin G.P., Syrbu A.I., Kyleshov A.P., Buchnev A.S., Drobyshev A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1423Цель работы

Цель работы: на математической модели исследовать влияние устройства генерации пульсирующего потока (ГПП) на основные гемодинамические параметры системы кровообращения.

Результаты

Результаты. В результате моделирования показано значительное (76%) увеличение пульсового давления в аорте при использовании ГПП. Предложенная математическая модель адекватно описывает динамику системы кровообращения и метаболизма (кислородный долг) на физическую нагрузку в условиях нормы и сердечной недостаточности и применения непульсируюшей и пульсирующей системы вспомогательного кровообращения. На математической модели показано также, что применение устройства ГПП блокирует развитие разрежения в полости левого желудочка, связанного с несоответствием притока и оттока крови в диастолической фазе, при необходимости увеличения системного кровотока за счет повышения скорости роторного насоса.

Objective

Objective: to study the effect of a pulsatile flow-generation (PFG) device on the basic hemodynamic parameters of the circulatory system using a mathematical model.

Results

Results. Modelling and simulation showed that the use of PFG significantly (76%) increases aortic pulse pressure. The proposed mathematical model adequately describes the dynamics of the circulatory system and metabolism (oxygen debt) on physical activity in normal conditions and heart failure, and the use of non-pulsatile and pulsatile circulatory-assist systems. The mathematical model also shows that the use of PFG device blocks the development of rarefaction in the left ventricular cavity associated with a mismatch of blood inflow and outflow in diastolic phase when there is need to increase systemic blood flow by increasing the rotary pump speed.

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The authors declare that there are no conflicts of interest present.