vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2021-3-180-185vtio-1398Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSРоль полиморфизма гена трансформирующего фактора роста β1 в развитии осложнений после трансплантации солидных органовThe role of TGF-β1 gene polymorphisms in the development of post-transplant complicationsКурабековаР. М.KurabekovaR. M.

Курабекова Ривада Мусабековна, отдел регуляторных механизмов в трансплантологии, главный научный сотрудник

Москва

Moscow

kourabr@yandex.ruГичкунО. Е.GichkunO. E.

Гичкун Ольга Евгеньевна, отдел регуляторных механизмов в трансплантологии, ведущий научный сотрудник

Москва

Moscow

gichkunoe@ya.ruМещеряковС. В.MeshcheryakovS. V.

Москва

 

Moscow

ШевченкоО. П.ShevchenkoO. P.

Шевченко Ольга Павловна, отдел регуляторных механизмов в трансплантологии, руководитель

123182, Москва, ул. Щукинская, д. 1

Olga P. Shevchenko

1, Shchukinskaya str., Moscow, 123182

transplant2009@mail.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет), Москва, Российская ФедерацияРоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityRussian Federation202117092021233180185Copyright © Курабекова Р.М., Гичкун О.Е., Мещеряков С.В., Шевченко О.П., 20212021Курабекова Р.М., Гичкун О.Е., Мещеряков С.В., Шевченко О.П.Kurabekova R.M., Gichkun O.E., Meshcheryakov S.V., Shevchenko O.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1398

Трансформирующий фактор роста β1 (TGF-β1) является иммуносупрессивным и профиброгенным цитокином и способен оказывать влияние на развитие отторжения и фиброза трансплантата у реципиентов солидных органов. Ген TGFВ1 обладает значительным полиморфизмом, который может служить причиной индивидуального уровня экспрессии белка и быть связан с осложнениями после трансплантации органов. Полагают, что 3 полиморфных варианта в гене TGFB1 (rs1800469, rs1800470 и rs1800471) могут быть ассоциированы с развитием отторжения, фиброза и хронической дисфункции трансплантата сердца, печени или почки. В обзоре данных современной литературы представлены результаты исследований о связи полиморфных вариантов гена TGFВ1 с посттрансплантационными осложнениями у реципиентов солидных органов. Выводы различных исследований генетического полиморфизма TGFB1 у реципиентов солидных органов не всегда однозначны, а их результаты зачастую сложно обобщить даже с помощью метаанализа. Включенные в исследования выборки различаются по этнической принадлежности, полу, возрасту и основным заболеваниям, тогда как результат сильно зависит от структуры выборки или скрытого родства. Имеющиеся в настоящее время данные позволяют полагать, что полиморфизм TGFВ1 может определять предрасположенность к развитию отторжения, фиброза и дисфункции трансплантата у реципиентов солидных органов, однако не дают возможности сделать однозначное заключение и требуют дальнейших, более масштабных исследований.

Transforming growth factor beta 1 (TGF-β1) is an immunosuppressive and profibrogenic cytokine capable of influencing the development of graft rejection and graft fibrosis in solid organ recipients. The TGF-β gene has a significant polymorphism that may cause individual protein expression levels and be associated with post-organ transplant complications. It is believed that three TGFB1 polymorphic variants (rs1800469, rs1800470 and rs1800471) may be associated with the development of graft rejection, graft fibrosis and chronic dysfunction of a heart, liver or kidney transplant. A review of current literature presents the results of studies on the relationship between TGF-β1 gene polymorphisms and post-transplant complications in solid organ recipients. The findings of various studies of TGF-β1 gene polymorphism in solid organ recipients are not always unambiguous, and their results are often difficult to generalize even with the help of meta-analysis. Samples included in studies vary in terms of ethnicity, gender, age, and underlying medical conditions, while results are highly dependent on sample structure or latent relatedness. Currently available data suggest that TGFB1 polymorphism may determine a predisposition to the development of graft rejection, graft fibrosis and graft dysfunction in solid organ recipients, but this is not conclusive and requires further, larger studies.

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The authors declare that there are no conflicts of interest present.