vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2013-1-31-38vtio-137Research ArticleКлиническая трансплантологияClinical TransplantologyБИОХИМИЧЕСКИЕ МАРКЕРЫ РЕЗОРБЦИИ КОСТИ И ГОРМОНАЛЬНАЯ РЕГУЛЯЦИЯ КОСТНОГО МЕТАБОЛИЗМА ПОСЛЕ ПЕРЕСАДКИ ПЕЧЕНИBIOCHEMICAL MARKERS OF BONE RESORPTION AND HORMONAL REGULATION OF BONE METABOLISM FOLLOWING LIVER TRANSPLANTATIONБузулинаВ. П.BuzulinaV. P.ПронченкоИ. А.PronchenkoI. A.ЕрмаковаИ. П.ErmakovaI. P.ШмеркоН. П.ShmerkoN. P.КорниловМ. Н.KornilovM. N.ЯрошенкоЕ. Б.YaroshenkoE. B.КолиашвилиТ. К.KoliashviliT. K.ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России, г. МоскваAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow201327052014151ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ том XV No 1–20133138Copyright © Бузулина В.П., Пронченко И.А., Ермакова И.П., Шмерко Н.П., Корнилов М.Н., Ярошенко Е.Б., Колиашвили Т.К., 20132013Бузулина В.П., Пронченко И.А., Ермакова И.П., Шмерко Н.П., Корнилов М.Н., Ярошенко Е.Б., Колиашвили Т.К.Buzulina V.P., Pronchenko I.A., Ermakova I.P., Shmerko N.P., Kornilov M.N., Yaroshenko E.B., Koliashvili T.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/137

Цель исследования: сравнительная оценка изменений двух маркеров резорбции и оценка состояния гор- мональной регуляции костной резорбции у реципиентов в различные сроки после трансплантации печени. Методы и результаты. В различные сроки после ортотопической трансплантации печени (ОТП) выпол- нено исследование минеральной плотности кости (МПК) в области поясничных позвонков (L2–L4) и шей- ки бедра, гормонов (ПТГ, витамина D3, эстрадиола, тестостерона), проведен сравнительный анализ двух маркеров резорбции БКЛ и КТРКФ-5б. Через 1 месяц после ОТП отмечено снижение МПК, уровня вита- мина D3, эстрадиола у женщин, тестостерона у мужчин, повышение маркеров резорбции кости. Через 1 и 2 года после ОТП минеральная плотность L2–L4 увеличивалась на фоне возрастания уровня ПТГ, половых гормонов и снижения БКЛ, в то время как уровни витамина D3 и КТРКФ-5б оставались стабильными. Заключение. Установлено, что КТРКФ-5б в ранние сроки после ОТП является более специфичным маркером резорбции кости. Остеопороз в поздние сроки ассоциировался с повышенными значениями КТРКФ-5б и у женщин с пониженным уровнем эстрадиола. 

Aim. Comparative evaluation of two biochemical markers of bone resorption and hormonal regulation of bone metabolism in liver recipients. Methods and results. Bоne densitometry of L2–L4 and neck of femur, serum level of some hormones (PTH, vitamin D3, estradiol, testosterone) regulating osteoclastogenesis as well as com- parative analyses of two bone resorption markers β-crosslaps and tartrate-resistant acid phosphatase type 5b (TRAP-5b) were fulfilled in patients after orthotopic liver transplantation (OLT). In 1 month after OLT bone density reduction of L2–L4 and neck of femur; decrease of vitamin D3, estradiol in women, testosterone in men and increase levels of bone resorption markers were observed. In 1 and 2 years after OLT the rise of bone density, increased levels of PTH, estradiol, testosterone and decreased β-crosslaps levels were revealed, while vitamin D3 and TRAP-5b levels remained stable. Conclusion. TRAP-5b was found to be a more speciffic marker of bone resorption, independent from collagen metabolism in liver. Osteoporosis defined in long-term period after OLT was associated with higher TRAP-5b and revialed in women with low estradiol level. 

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The authors declare that there are no conflicts of interest present.