vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2021-3-186-191vtio-1356Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSЛимфообращение и сердечная недостаточностьLymphatic circulation and heart failureИткинГ. П.ItkinG. P.

Иткин Георгий Пинкусович

Лаборатория биотехнических систем

123182, Москва, ул. Щукинская, д. 1

Georgiy P. Itkin

1, Shchukinskaya str., Moscow, 123182

georgeitkin@mail.ruИткинМ. Г.ItkinM. G.

Филадельфия

Philadelfia PN

ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Московский физико-технический институт (национальный исследовательский университет)»РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Moscow Institute of Physics and TechnologyRussian FederationУниверситет штата ПенсильванияСоединённые Штаты АмерикиPensilvenia State UniversityUnited States202117092021233186191Copyright © Иткин Г.П., Иткин М.Г., 20212021Иткин Г.П., Иткин М.Г.Itkin G.P., Itkin M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1356

Цель работы: обобщить современные знания о взаимодействиях между лимфатической, сердечно-сосудистой системами и интерстициальной тканью, которые связаны с сердечной недостаточностью (СН). Авторы в настоящей статье пытаются ответить на фундаментальный вопрос, являются ли аномалии лимфатической системы (ЛС) причиной или следствием СН. Понимание процессов лимфообразования в условиях СН позволит найти новые пути лечения СН.

Objective: to summarize current knowledge about the interactions between the lymphatic/cardiovascular systems and interstitial tissue, which are associated with heart failure (HF). The authors attempt to answer the fundamental question of whether lymphatic insufficiency is a cause or consequence of HF. Understanding lymph formation processes in HF will allow finding new ways of treating HF.

лимфатическая системасердечная недостаточностьуравнение Старлингаинтерсцициальная жидкостьлимфалимфодренажlymphatic systemheart failureStarling equationinterstitial fluidlymphlymphatic drainageReferencesStarling EH. The Influence of Mechanical Factors on Lymph Production. J Physiol. 1894: 224–267.Starling EH. The Influence of Mechanical Factors on Lymph Production. J Physiol. 1894: 224–267.Starling EH. On the Absorption of Fluids from the Connective Tissue Spaces. J Physiol. 1896; 19 (4): 312–326.Starling EH. On the Absorption of Fluids from the Connective Tissue Spaces. J Physiol. 1896; 19 (4): 312–326.Starling E. The Arris and Bale Lectures on Some points in the pathology of the heart disease. Lecture 2, the effect of the heart failure on the circulation. Lancet. 1897; 149 (3836): 652–655.Starling E. The Arris and Bale Lectures on Some points in the pathology of the heart disease. Lecture 2, the effect of the heart failure on the circulation. Lancet. 1897; 149 (3836): 652–655.Guyton AC, Lindsey AW, Johnnie OH, John WW, Malcolma AF. Effect of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary edema. Circ Res. 1959; 7 (4): 649– 657.Guyton AC, Lindsey AW, Johnnie OH, John WW, Malcolma AF. Effect of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary edema. Circ Res. 1959; 7 (4): 649– 657.Michel CC. Starling: The formulation of his hypothesis of microvascular fluid exchange and its significacance after 100 years. Exp Physiol. 1997 Jan; 82 (1): 1–30.Michel CC. Starling: The formulation of his hypothesis of microvascular fluid exchange and its significacance after 100 years. Exp Physiol. 1997 Jan; 82 (1): 1–30.Scholander APF, Hargens AR, Miller SL. Negative Pressure in the Interstitial Fluid of Animals. Fluid tensions are spectacular in plants; in animals they are elusively small, but just as vital. Science. 1968; 161 (3839): 321– 322.Scholander APF, Hargens AR, Miller SL. Negative Pressure in the Interstitial Fluid of Animals. Fluid tensions are spectacular in plants; in animals they are elusively small, but just as vital. Science. 1968; 161 (3839): 321– 322.Levick JR. Capillary filtration-absorption balance reconsidered in light of dynamic extravascular factors. Exp Physiol. 1991; 76 (6): 825–857.Levick JR. Capillary filtration-absorption balance reconsidered in light of dynamic extravascular factors. Exp Physiol. 1991; 76 (6): 825–857.Levick JR. Introduction to cardiovascular physiology. 1989.Levick JR. Introduction to cardiovascular physiology. 1989.Michel CC, Phillips ME. Steady-state fluid filtration at different capillary pressures in perfused frog mesenteric capillaries. J Physiol. 1987; 388 (1): 421–435.Michel CC, Phillips ME. Steady-state fluid filtration at different capillary pressures in perfused frog mesenteric capillaries. J Physiol. 1987; 388 (1): 421–435.Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010; 87 (2): 198–210.Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010; 87 (2): 198–210.Guyton AC, Granger HJ, Taylor AE. Interstitial fluid pressure. Physiol Rev. 1971; 51 (3): 527–563.Guyton AC, Granger HJ, Taylor AE. Interstitial fluid pressure. Physiol Rev. 1971; 51 (3): 527–563.Scallan JP, Zawieja SD, Castorena-Gonzalez JA, Davis MJ. Lymphatic pumping: mechanics, mechanisms and malfunction. J Physiol. 2016: 5749–68.Scallan JP, Zawieja SD, Castorena-Gonzalez JA, Davis MJ. Lymphatic pumping: mechanics, mechanisms and malfunction. J Physiol. 2016: 5749–68.Davis MJ, Rahbar E, Gashev AA, Zawieja DC, Moore JE. Determinants of valve gating in collecting lymphatic vessels from rat mesentery. Am J Physiol Heart Circ Physiol. 2011; 301 (1): H48–60.Davis MJ, Rahbar E, Gashev AA, Zawieja DC, Moore JE. Determinants of valve gating in collecting lymphatic vessels from rat mesentery. Am J Physiol Heart Circ Physiol. 2011; 301 (1): H48–60.Unthank JL, Bohlen HG. Lymphatic pathways and role of valves in lymph propulsion from small intestine. Am J Physiol Liver Physiol. 2017; 254 (3): G389–398.Unthank JL, Bohlen HG. Lymphatic pathways and role of valves in lymph propulsion from small intestine. Am J Physiol Liver Physiol. 2017; 254 (3): G389–398.Von Der Weid PY, Zawieja DC. Lymphatic smooth muscle: The motor unit of lymph drainage. Int J Biochem Cell Biol. 2004; 36 (7): 1147–53.Von Der Weid PY, Zawieja DC. Lymphatic smooth muscle: The motor unit of lymph drainage. Int J Biochem Cell Biol. 2004; 36 (7): 1147–53.Olszewski WL, Engeset A. Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg. Am J Physiol. 1980; 239 (6): H775–H777.Olszewski WL, Engeset A. Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg. Am J Physiol. 1980; 239 (6): H775–H777.Aspelund A, Robcluc MR, Karaman S, Makinen K. Lymphatic System in Cardiovascular Medicine. Circulation Research. 2016; 118: 515–530.Aspelund A, Robcluc MR, Karaman S, Makinen K. Lymphatic System in Cardiovascular Medicine. Circulation Research. 2016; 118: 515–530.Jones D, Min W. An overview of lymphatic vessels and their emerging role in cardiovascular disease. Journal of Cardiovascular Disease Research. 2011; 2 (3): 141–152.Jones D, Min W. An overview of lymphatic vessels and their emerging role in cardiovascular disease. Journal of Cardiovascular Disease Research. 2011; 2 (3): 141–152.Voors AA, Davison BA, Teerlink JR, Felker GM, Cotter G, Filippatos G et al. RELAX-AHF Investigators. Diuretic response in patients with acute decompensated heart failure: characteristics and clinical outcome – an analysis from RELAX-AHF. Eur J Heart Fail. 2014; 16: 1230–1240.Voors AA, Davison BA, Teerlink JR, Felker GM, Cotter G, Filippatos G et al. RELAX-AHF Investigators. Diuretic response in patients with acute decompensated heart failure: characteristics and clinical outcome – an analysis from RELAX-AHF. Eur J Heart Fail. 2014; 16: 1230–1240.Valente MA, Voors AA, Damman K, Van Veldhuisen DJ, Massie BM, O’Connor CM et al. Diuretic response in acute heart failure: clinical characteristics and prognostic significance. Eur Heart J. 2014; 35: 1284–1293.Valente MA, Voors AA, Damman K, Van Veldhuisen DJ, Massie BM, O’Connor CM et al. Diuretic response in acute heart failure: clinical characteristics and prognostic significance. Eur Heart J. 2014; 35: 1284–1293.Engeset A, Olszewski W, Jæger PM, Sokolowski J, Theodorsen L. Twenty-Four Hour Variation in Flow and Composition of Leg Lymph in Normal Men. Acta Physiol Scand. 1977; 99 (2): 140–148.Engeset A, Olszewski W, Jæger PM, Sokolowski J, Theodorsen L. Twenty-Four Hour Variation in Flow and Composition of Leg Lymph in Normal Men. Acta Physiol Scand. 1977; 99 (2): 140–148.Allen SJ, Drake RE, Laine GA, Gabel JC. Effect of thoracic duct drainage on hydrostatic pulmonary edema and pleural effusion in sheep. J Appl Physiol. 1991; 71 (1): 314–316.Allen SJ, Drake RE, Laine GA, Gabel JC. Effect of thoracic duct drainage on hydrostatic pulmonary edema and pleural effusion in sheep. J Appl Physiol. 1991; 71 (1): 314–316.Dumont AE, Clauss RH, Reed GE, Tice DA. Lymph Drainage in Patients with Congestive Heart Failure. N Engl J Med. 1963; 269 (18): 949–952.Dumont AE, Clauss RH, Reed GE, Tice DA. Lymph Drainage in Patients with Congestive Heart Failure. N Engl J Med. 1963; 269 (18): 949–952.Witte MH, Dumon AE, Clauss RH, Rader B, Levine N, Breed ES. Lymph Circulation in Congestive Heart Failure: Effect of External Thoracic Duct Drainage. Circulation. 1969; 39 (6): 723–733.Witte MH, Dumon AE, Clauss RH, Rader B, Levine N, Breed ES. Lymph Circulation in Congestive Heart Failure: Effect of External Thoracic Duct Drainage. Circulation. 1969; 39 (6): 723–733.Clauss RH, Breed ES. Controlled rate of drainage of thoracic duct lymph. Am J Surg. 1970; 119 (5): 610–612.Clauss RH, Breed ES. Controlled rate of drainage of thoracic duct lymph. Am J Surg. 1970; 119 (5): 610–612.Hraška V. Decompression of thoracic duct: New approach for the treatment of failing.Hraška V. Decompression of thoracic duct: New approach for the treatment of failing.Chavhan GB, Amaral JG, Temple M, Itkin M. MR Lymphangiography in Children: Technique and Potential Applications. Radiographics. 2017; 37 (6): 1775–1790.Chavhan GB, Amaral JG, Temple M, Itkin M. MR Lymphangiography in Children: Technique and Potential Applications. Radiographics. 2017; 37 (6): 1775–1790.Dori Y, Zviman MMMM, Itkin M. Dynamic Contrastenhanced MR Lymphangiography: Feasibility Study in Swine. Radiology. 2014; 273 (2): 410–416.Dori Y, Zviman MMMM, Itkin M. Dynamic Contrastenhanced MR Lymphangiography: Feasibility Study in Swine. Radiology. 2014; 273 (2): 410–416.Butler J, Hamo CE, Udelson JE, Pitt B, Yancy C, Shah S et al. Exploring New Endpoints for Patients with Heart Failure with Preserved Ejection Fraction. Circ Hear Fail. 2016; 9 (11): 1–8.Butler J, Hamo CE, Udelson JE, Pitt B, Yancy C, Shah S et al. Exploring New Endpoints for Patients with Heart Failure with Preserved Ejection Fraction. Circ Hear Fail. 2016; 9 (11): 1–8.

The authors declare that there are no conflicts of interest present.