vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2021-3-142-147vtio-1352Research ArticleРЕГЕНЕРАТИВНАЯ МЕДИЦИНА И КЛЕТОЧНЫЕ ТЕХНОЛОГИИREGENERATIVE MEDICINE AND CELL TECHNOLOGIESКлетки Сертоли: иммуномодулирующие свойства, способы выделения и культивированияSertoli cells: immunomodulatory properties, methods of isolation and cultureСкалецкийН. Н.SkaletskiyN. N.

Скалецкий Николай Николаевич, главный специалист

123182, Москва, ул. Щукинская, д. 1

Nikolay N. Skaletskiy

1, Shchukinskaya str., Moscow, 123182

nskaletsky@mail.ruСкалецкаяГ. Н.SkaletskayaG. N.

Скалецкая Галина Николаевна

Москва

Moscow

skalink@mail.ruФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian Federation202117092021233142147Copyright © Скалецкий Н.Н., Скалецкая Г.Н., 20212021Скалецкий Н.Н., Скалецкая Г.Н.Skaletskiy N.N., Skaletskaya G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1352

В связи с осложнениями, обусловленными неизбежным применением иммуносупрессивных препаратов при трансплантации органов и клеток, вызывает интерес использование естественных механизмов обеспечения иммунологической толерантности, выявленных в организмах животных и человека. Давно известно, что в них имеются определенные области, в том числе семенник, где иммунные реакции практически невозможны. В настоящем обзоре основное внимание уделено роли клеток Сертоли, обеспечивающих иммунопривилегированность семенника. Описываются способы изоляции и культивирования клеток Сертоли и обсуждаются возможности их использования в биологии и медицине.

Due to complications caused by the inevitable use of immunosuppressive drugs in organ and cell transplantation, the use of natural mechanisms of immunological tolerance identified in animal and human organisms arouses interest. It has long been known that there are certain areas in them, including the testis, where immune reactions are virtually impossible. Our review focuses on the role of Sertoli cells that provide testicular immune privilege. Methods of isolation and cultivation of Sertoli cells are described and their potentials in biology and medicine are discussed.

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The authors declare that there are no conflicts of interest present.