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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/25/1995-1191-2021-4-132-142</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Имплантаты и искусственные органы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Implants and Artificial Organs</subject></subj-group></article-categories><title-group><article-title>Компьютерное моделирование заплат различной формы при классической каротидной эндартерэктомии</article-title><trans-title-group xml:lang="en"><trans-title>Computer modeling of different shaped patches in classical carotid endarterectomy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисов</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisov</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Kemerovo</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захаров</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharov</surname><given-names>Yu. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Kemerovo</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казанцев</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazantsev</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казанцев Антон Николаевич</p><p>193312, Санкт-Петербург, проспект Солидарности, д. 4</p><p>Тел. (908) 947-47-57</p></bio><bio xml:lang="en"><p>Anton Kazantsev</p><p>4, Solidarity Avenue, St. Petersburg, 193312, Russian Federation</p><p>Phone: (908) 947-47-57</p></bio><email xlink:type="simple">dr.antonio.kazantsev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шокин</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shokin</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Kemerovo</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евтушенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Evtushenko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово</p></bio><bio xml:lang="en"><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово</p></bio><bio xml:lang="en"><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Онищенко</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Onishchenko</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Novosibirsk</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клышников</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Klyshnikov</surname><given-names>K. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово</p></bio><bio xml:lang="en"><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчаренко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovcharenko</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово</p></bio><bio xml:lang="en"><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кемеровский государственный университет; Институт вычислительных технологий</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State University; Federal Research Center for Information and Computational Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Городская Александровская больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Alexandrovskaya Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт вычислительных технологий</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State University; Federal Research Center for Information and Computational Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Problems of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Институт вычислительных технологий; ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Information and Computational Technologies; Research Institute for Complex Problems of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>22</day><month>10</month><year>2021</year></pub-date><volume>23</volume><issue>4</issue><fpage>132</fpage><lpage>142</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Борисов В.Г., Захаров Ю.Н., Казанцев А.Н., Шокин Ю.И., Евтушенко А.В., Барбараш Л.С., Онищенко П.С., Клышников К.Ю., Овчаренко Е.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Борисов В.Г., Захаров Ю.Н., Казанцев А.Н., Шокин Ю.И., Евтушенко А.В., Барбараш Л.С., Онищенко П.С., Клышников К.Ю., Овчаренко Е.А.</copyright-holder><copyright-holder xml:lang="en">Borisov V.G., Zakharov Y.N., Kazantsev A.N., Shokin Y.I., Evtushenko E.V., Barbarash L.S., Onishchenko P.S., Klyshnikov K.Y., Ovcharenko E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1338">https://journal.transpl.ru/vtio/article/view/1338</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: описание метода построения геометрических моделей бифуркации сонной артерии с помощью компьютерного моделирования операций каротидной эндартерэктомии (КЭА) с заплатами различной конфигурации.</p></sec><sec><title>Материлы и методы</title><p>Материлы и методы. Метод использует реконструированные модели здорового сосуда, полученные с помощью предоперационного компьютерного томографического исследования пораженного сосуда конкретного пациента. Течение в сосуде моделируется методом вычислительной гидродинамики с использованием данных ультразвуковой доплеровской велосиметрии пациента. Факторы риска оцениваются по гемодинамическим показателям на стенке сосуда, связанным с WSS.</p></sec><sec><title>Результаты</title><p>Результаты. В работе с помощью предложенного метода исследованы гемодинамические результаты 10 виртуальных операций КЭА с заплатами различной формы на примере реконструированной здоровой артерии конкретного пациента. Смысл имплантации заплаты состоит в том, чтобы в результате операции просвет сосуда не был сужен, поскольку закрытие разреза без заплаты может уменьшить длину окружности просвета сосуда на 4–5 мм, что неблагоприятно сказывается на кровотоке. С другой стороны, слишком широкая заплата создает аневризмоморфную деформацию устья внутренней сонной артерии (ВСА), что не является оптимальным ввиду формирования большой зоны рециркуляции. В рассматриваемом случае установлено, что ширина имплантированной заплаты, приблизительно равная 3 мм, обеспечивает оптимальный гемодинамический результат. Отклонения от этого медианного значения как в большую, так и в меньшую сторону ухудшают гемодинамику, а отсутствие заплаты дает наихудший из рассмотренных результатов.</p></sec><sec><title>Заключение</title><p>Заключение. Предложенная методика компьютерного моделирования способна обеспечить персонифицированный подбор заплаты для классической КЭА с низким риском развития рестеноза в отдаленном периоде наблюдения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to construct geometric models of carotid bifurcation and build a computer modeling for carotid endarterectomy (CEA) operations with patches of various configurations.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The method uses reconstructed models of a healthy blood vessel obtained from a preoperative computed tomography (CT) study of the affected blood vessel of a particular patient. Flow in the vessel is simulated by computational fluid dynamics using data from the patient's ultrasonic Doppler velocimetry and CT angiography. Risk factors are assessed by hemodynamic indices at the vessel wall associated with Wall Shear Stress (WSS).</p></sec><sec><title>Results</title><p>Results. We used the proposed method to study the hemodynamic results of 10 virtual CEA operations with patches of various shapes on a reconstructed healthy artery of a particular patient. The reason for patch implantation was to ensure that the vessel lumen is not narrowed as a result of the surgery, since closing the incision without a patch can reduce the vessel lumen circumference by 4–5 mm, which adversely affects blood flow. On the other hand, too wide a patch creates aneurysmorphic deformation of the internal carotid artery (ICA) mouth, which is not optimal due to formation of a large recirculation zone. In this case, it was found that the implanted patch width of about 3 mm provides an optimal hemodynamic outcome. Deviations from this median value, both upward and downward, impair hemodynamics. The absence of a patch gives the worst of the results considered.</p></sec><sec><title>Conclusion</title><p>Conclusion: The proposed computer modeling technique is able to provide a personalized patch selection for classical CEA with low risk of restenosis in the long-term follow-up.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>каротидная эндартерэктомия</kwd><kwd>классическая каротидная эндартерэктомия</kwd><kwd>заплата</kwd><kwd>компьютерное моделирование</kwd><kwd>заплата</kwd></kwd-group><kwd-group xml:lang="en"><kwd>classical carotid endarterectomy</kwd><kwd>computer modeling</kwd><kwd>patch</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Казанцев АН, Тарасов РС, Бурков НН, Шабаев АР, Лидер РЮ, Миронов АВ. Каротидная эндартерэктомия: трехлетние результаты наблюдения в рамках одноцентрового регистра. Ангиология и сосудистая хирургия. 2018; 24 (3): 101–108.</mixed-citation><mixed-citation xml:lang="en">Kazantsev AN, Tarasov RS, Burkov NN, Shabaev AR, Leader RYu, Mironov AV. Carotid endarterectomy: three-year follow-up in a single-center registry. Angiology and vascular surgery. 2018; 24 (3): 101–108. [In Russ, English abstract].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Казанцев АН, Тарасов РС, Бурков НН, Волков АН, Грачев КИ, Яхнис ЕЯ и др. Госпитальные результаты чрескожного коронарного вмешательства и каротидной эндартерэктомии в гибридном и поэтапном режимах. Ангиология и сосудистая хирургия. 2019; 25 (1): 101–107.</mixed-citation><mixed-citation xml:lang="en">Kazantsev AN, Tarasov RS, Burkov NN, Volkov AN, Grachev KI, Yakhnis EYa et al. Hospital results of percutaneous coronary intervention and carotid endarterectomy in hybrid and phased modes. Angiology and vascular surgery. 2019; 25 (1): 101–107. [In Russ, English abstract]. doi: 10.33529/angio2019114.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zhong L, Zhang JM, Su B et al. Application of Patient- Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities. Front Physiol. 2018; 9: 742. doi: 10.3389/fphys.2018.00742.</mixed-citation><mixed-citation xml:lang="en">Zhong L, Zhang JM, Su B et al. Application of Patient- Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities. Front Physiol. 2018; 9: 742. doi: 10.3389/fphys.2018.00742.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gijsen F, Katagiri Y, Barlis P et al. Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. Eur Heart J. 2019; 40 (41): 3421–3433. doi: 10.1093/eurheartj/ehz551.</mixed-citation><mixed-citation xml:lang="en">Gijsen F, Katagiri Y, Barlis P et al. Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. Eur Heart J. 2019; 40 (41): 3421–3433. doi: 10.1093/eurheartj/ehz551.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Borisov VG, Zakharov YN, Shokin YI et al. Numerical Method for Predicting Hemodynamic Effects in Vascular Prostheses. Numer Analys. 2019; 12: 326–337. doi: 10.1134/S1995423919040025.</mixed-citation><mixed-citation xml:lang="en">Borisov VG, Zakharov YN, Shokin YI et al. Numerical Method for Predicting Hemodynamic Effects in Vascular Prostheses. Numer Analys. 2019; 12: 326–337. doi: 10.1134/S1995423919040025.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Harrison GJ, How TV, Poole RJ, Brennan JA, Naik JB, Vallabhaneni SR, Fisher RK. Closure technique after carotid endarterectomy influences local hemodynamics. J Vasc Surg. 2014; 60 (2): 418–427. doi: 10.1016/j.jvs.2014.01.069.</mixed-citation><mixed-citation xml:lang="en">Harrison GJ, How TV, Poole RJ, Brennan JA, Naik JB, Vallabhaneni SR, Fisher RK. Closure technique after carotid endarterectomy influences local hemodynamics. J Vasc Surg. 2014; 60 (2): 418–427. doi: 10.1016/j.jvs.2014.01.069.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Geers AJ, Morales HG, Larrabide I, Butakoff C, Bijlenga P, Frangi AF. Wall shear stress at the initiation site of cerebral aneurysms. Biomech Model Mechanobiol. 2017; 16 (1): 97–115. doi: 10.1007/s10237-016-0804-3.</mixed-citation><mixed-citation xml:lang="en">Geers AJ, Morales HG, Larrabide I, Butakoff C, Bijlenga P, Frangi AF. Wall shear stress at the initiation site of cerebral aneurysms. Biomech Model Mechanobiol. 2017; 16 (1): 97–115. doi: 10.1007/s10237-016-0804-3.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Steinman DA. Image-based computational fluid dynamics modeling in realistic arterial geometries. Ann Biomed Eng. 2002; 30 (4): 483–497. doi: 10.1114/1.1467679.</mixed-citation><mixed-citation xml:lang="en">Steinman DA. Image-based computational fluid dynamics modeling in realistic arterial geometries. Ann Biomed Eng. 2002; 30 (4): 483–497. doi: 10.1114/1.1467679.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hoskins PR, Hardman D. Three-dimensional imaging and computational modelling for estimation of wall stresses in arteries. Br J Radiol. 2009 Jan; 82 Spec No 1: S3–17. doi: 10.1259/bjr/96847348.</mixed-citation><mixed-citation xml:lang="en">Hoskins PR, Hardman D. Three-dimensional imaging and computational modelling for estimation of wall stresses in arteries. Br J Radiol. 2009 Jan; 82 Spec No 1: S3–17. doi: 10.1259/bjr/96847348.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Avrahami I, Raz D, Bash O. Biomechanical Aspects of Closing Approaches in Postcarotid Endarterectomy. Comput Math Methods Med. 2018; 2018: 4517652. doi: 10.1155/2018/4517652.</mixed-citation><mixed-citation xml:lang="en">Avrahami I, Raz D, Bash O. Biomechanical Aspects of Closing Approaches in Postcarotid Endarterectomy. Comput Math Methods Med. 2018; 2018: 4517652. doi: 10.1155/2018/4517652.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Казанцев АН, Бурков НН, Захаров ЮН, Борисов ВГ, Лидер РЮ, Баяндин МС, Ануфриев АИ. Персонифицированная реваскуляризация головного мозга: метод компьютерного моделирования зоны реконструкции для проведения каротидной эндартерэктомии. Хирургия. Журнал им. Н.И. Пирогова. 2020; (6): 71–75.</mixed-citation><mixed-citation xml:lang="en">Kazantsev AN, Burkov NN, Zakharov YuN, Borisov VG, Lider RYu, Bayandin MS, Anufriev AI. Personalized brain revascularization: a method of computer modeling of the reconstruction area for carotid endarterectomy. Surgery. 2020; (6): 71–75. [In Russ, English abstract]. doi: 10.17116/hirurgia202006171.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Казанцев АН, Бурков НН, Борисов ВГ, Захаров ЮН, Сергеева ТЮ, Шабаев АР и др. Компьютерное моделирование гемодинамических показателей в бифуркации сонных артерий после каротидной эндартерэктомии. Ангиология и сосудистая хирургия. 2019; 25 (3): 107–112.</mixed-citation><mixed-citation xml:lang="en">Kazantsev AN, Burkov NN, Borisov VG, Zakharov YN, Sergeeva Tyu, Shabaev AR et al. Computer modeling of hemodynamic parameters in the bifurcation of the carotid arteries after carotid endarterectomy. Angiology and Vascular Surgery. 2019; 25 (3): 107–112. [In Russ, English abstract]. doi: 10.33529/ANGIO2019311.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Казанцев АН, Виноградов РА, Захаров ЮН, Борисов ВГ, Чернявский МА, Кравчук ВН и др. Прогнозирование рестеноза после каротидной эндартерэктомии методом компьютерного моделирования. Неотложная медицинская помощь. Журнал им. Н.В. Склифосовского. 2021; 10 (2): 401–407.</mixed-citation><mixed-citation xml:lang="en">Kazantsev AN, Vinogradov RA, Zakharov YN, Borisov VG, Chernyavsky MA, Kravchuk VN et al. Prediction of restenosis after carotid endarterectomy by computer simulation. Emergency medical care. Journal them. N.V. Sklifosovsky. 2021; 10 (2): 401–407.doi: 10.23934/2223-9022-2021-10-2-401-407.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
