vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2021-1-60-74vtio-1316Research ArticleРЕГЕНЕРАТИВНАЯ МЕДИЦИНА И КЛЕТОЧНЫЕ ТЕХНОЛОГИИREGENERATIVE MEDICINE AND CELL TECHNOLOGIESМатериалы для создания тканеинженерных конструкций методом 3D-биопечати при восстановлении хрящевой и мягких тканейMaterials for creating tissue-engineered constructs using 3D bioprinting: cartilaginous and soft tissue restorationАргучинскаяН. В.ArguchinskayaN. V.

249036, Калужская область, Обнинск, ул. Королева, д. 4.

4, Koroleva str., Obninsk, 249036, Kaluga Oblast.

БекетовЕ. Е.BeketovE. E.

Бекетов Евгений Евгеньевич.

249036, Калужская область, Обнинск, ул. Королева, д. 4.

Тел. (960) 523-64-49

Evgeny Beketov.

4, Koroleva str., Obninsk, 249036, Kaluga Oblast.

Phone: (960) 523-64-49

beketov.ee@yandex.ruИсаеваЕ. В.IsaevaE. V.

249036, Калужская область, Обнинск, ул. Королева, д. 4.

4, Koroleva str., Obninsk, 249036, Kaluga Oblast.

СергееваН. С.SergeevaN. S.

Москва.

Moscow.

ШегайП. В.ShegayP. V.

Москва.

Moscow.

ИвановС. А.IvanovS. A.

249036, Калужская область, Обнинск, ул. Королева, д. 4.

4, Koroleva str., Obninsk, 249036, Kaluga Oblast.

КапринА. Д.KaprinA. D.

Москва.

Moscow.

Медицинский радиологический научный центр имени А.Ф. Цыба - филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииРоссияTsyb Medical Radiological Research CenterRussian FederationМосковский научно-исследовательский онкологический институт имени П.А. Герцена -филиал ФГБУ «НМИЦ радиологии» Минздрава России, Москва, Российская Федерация; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава РоссииРоссияHertsen Moscow Oncology Research Institute; Pirogov Medical UniversityRussian FederationНациональный медицинский исследовательский центр радиологии Минздрава РоссииРоссияNational Medical Research Radiological CenterRussian Federation2021100420212316074Copyright © Аргучинская Н.В., Бекетов Е.Е., Исаева Е.В., Сергеева Н.С., Шегай П.В., Иванов С.А., Каприн А.Д., 20212021Аргучинская Н.В., Бекетов Е.Е., Исаева Е.В., Сергеева Н.С., Шегай П.В., Иванов С.А., Каприн А.Д.Arguchinskaya N.V., Beketov E.E., Isaeva E.V., Sergeeva N.S., Shegay P.V., Ivanov S.A., Kaprin A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1316

3D-биопечать - динамично развивающаяся технология тканевой инженерии и регенеративной медицины. Основным преимуществом данного метода является возможность воспроизведения заданной геометрии и структуры скаффолда как в отношении формы тканеинженерной конструкции, так и распределения ее компонентов. Ключевым фактором биопечати являются биочернила - биосовместимый материал, имитирующий внеклеточный матрикс с инкорпорированными в него клетками. Для соответствия всем предъявляемым требованиям биочернила должны включать в себя не только основной компонент, но и другие составляющие, обеспечивающие пролиферацию, дифференцировку клеток и функционирование тканевой конструкции в целом. Целью обзора является анализ свойств, возможностей и ограничений в использовании наиболее распространенных материалов для биопечати скаффолдов хрящевой ткани.

3D Bioprinting is a dynamically developing technology for tissue engineering and regenerative medicine. The main advantage of this technique is its ability to reproduce a given scaffold geometry and structure both in terms of the shape of the tissue-engineered construct and the distribution of its components. The key factor in bioprinting is bio ink, a cell-laden biocompatible material that mimics extracellular matrix. To meet all the requirements, the bio ink must include not only the main material, but also other components ensuring cell proliferation, differentiation and scaffold performance as a whole. The purpose of this review is to describe the most common materials applicable in bioprinting, consider their properties, prospects and limitations in cartilage restoration.

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The authors declare that there are no conflicts of interest present.