vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2021-1-8-14vtio-1309Research ArticleТРАНСПЛАНТАЦИЯ ОРГАНОВORGAN TRANSPLANTATIONСтеатоз печени доноров со смертью мозгаLiver steatosis in brain death donorsВороновД. В.VoronovD. V.

Москва.

Moscow.

МининаМ. Г.MininaM. G.

Moscow.

ЧомаевА. К.ChomaevA. K.

123182, Москва, ул. Щукинская, д. 1.

1, Shchukinskaya str., Moscow, 123182.

ИльинскийИ. М.IljinskyI. M.

Ильинский Игорь Михайлович.

123182, Москва, ул. Щукинская, д. 1.

Тел. (999) 877-60-95

Igor Iljinsky.

1, Shchukinskaya str., Moscow, 123182.

Phone: (999) 877-60-95

iiljinsky@mail.ruЦирульниковаО. М.TsirulnikovaO. M.

Москва.

Moscow.

Городская клиническая больница имени С.П. Боткина Департамента здравоохранения города Москвы, Московский координационный центр органного донорстваРоссияBotkin City Clinical Hospital , Moscow coordinating center of organ donationRussian FederationНациональный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова Минздрава РоссииРоссияShumakov National Medical Research Center of Transplantology and Artificial OrgansRussian FederationНациональный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова Минздрава России; Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет)РоссияShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityRussian Federation202109042021231814Copyright © Воронов Д.В., Минина М.Г., Чомаев А.К., Ильинский И.М., Цирульникова О.М., 20212021Воронов Д.В., Минина М.Г., Чомаев А.К., Ильинский И.М., Цирульникова О.М.Voronov D.V., Minina M.G., Chomaev A.K., Iljinsky I.M., Tsirulnikova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1309

Цель исследования - изучение частоты жирового гепатоза в биоптатах печени последовательных доноров со смертью мозга до холодовой консервации. Материалы и методы. Исследованы биоптаты печени (до холодовой консервации) 300 последовательных доноров со смертью головного мозга. Гистологические препараты окрашивали гематоксилином и эозином, а также проводили трехцветную окраску по Массону. Результаты. Частота различных степеней жирового гепатоза у мужчин и женщин отличалась незначимо (>0,05). Жировая дистрофия гепатоцитов отсутствовала более чем в половине наблюдений (n = 182; 60,7%). Легкая степень жировой дистрофии диагностирована у 57 (19,0%) доноров. В совокупности вполне пригодными для трансплантации были 239 (79,7%) донорских печеней. Умеренная степень стеатоза, с которой связывают ранние билиарные осложнения, выявлена в 18 (6,0%) наблюдениях, а тяжелая степень, являющаяся противопоказанием использования органа для трансплантации, - в 43 (14,3%) наблюдениях. Заключение. До холодовой консервации печень от доноров со смертью головного мозга относительно редко бывает непригодной для трансплантации.

Aim. To study the frequency of fatty hepatosis in liver biopsies of consecutive brain death donors before cold preservation. Materials and methods. Liver biopsies (before cold preservation) of 300 consecutive donors with brain death were studied. Histological preparations were stained with hematoxylin and eosin, and tricolor Masson staining was performed. Results. The frequency of different degrees of fat hepatosis in men and women did not differ significantly (>0.05). Fat dystrophy of hepatocytes was absent in more than half of the cases (n = 182; 60.7%). A slight degree of fatty degeneration was diagnosed in 57 (19,0%) donors. In total, 239 (79.7%) donor livers were absolutely suitable for transplantation. Moderate degree of steatosis, which is associated with early biliary complications, was detected in 18 (6.0%) cases, and severe degree, which is a contraindication to the use of the organ for transplantation, was detected in 43 (14.3%) cases. Conclusion. Before cold preservation, liver from brain death donors is relatively rarely unsuitable for transplantation.

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The authors declare that there are no conflicts of interest present.