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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2020-3-36-42</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1225</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая трансплантология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Transplantology</subject></subj-group></article-categories><title-group><article-title>Эффективность альбуминового диализа в качестве моста к трансплантации у детей с терминальными заболеваниями печени</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy of albumin dialysis as a bridge to transplantation in children with end-stage liver disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Строков</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Strokov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Строков Александр Григорьевич.</p><p>Адрес: 123182, Москва, ул. Щукинская, д. 1.</p><p>Тел. (499) 158-22-33.</p></bio><bio xml:lang="en"><p>Alexander Strokov.</p><p>Address: 1, Shchukinskaya str., Moscow, 123182, Russian Federation. </p><p>Phone: (499) 158-22-33.</p></bio><email xlink:type="simple">medick@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поз</surname><given-names>Я. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Poz</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Монахов</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Monakhov</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мещеряков</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshcheryakov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Восканов</surname><given-names>М. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Voskanov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Готье</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gautier</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)<country>Россия</country></aff><aff xml:lang="en">Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Shumakov National Medical Research Center of Transplantology and Artificial Organs<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>06</day><month>10</month><year>2020</year></pub-date><volume>22</volume><issue>3</issue><fpage>36</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Строков А.Г., Поз Я.Л., Монахов А.Р., Мещеряков С.В., Восканов М.A., Готье С.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Строков А.Г., Поз Я.Л., Монахов А.Р., Мещеряков С.В., Восканов М.A., Готье С.В.</copyright-holder><copyright-holder xml:lang="en">Strokov A.G., Poz I.L., Monakhov A.R., Meshcheryakov S.V., Voskanov M.A., Gautier S.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1225">https://journal.transpl.ru/vtio/article/view/1225</self-uri><abstract><p>Введение. У пациентов с терминальными заболеваниями печени трансплантация является единственным эффективным методом лечения. Однако донорский орган не всегда бывает доступен, а в ряде случаев осуществлению трансплантации препятствует тяжесть состояния больного. В связи с этим применение искусственных систем поддержки функции печени позволяет подготовить пациента к трансплантации. Целью данного ретроспективного исследования послужила оценка эффективности системы сепарации и адсорбции фракционированной плазмы (Fractionated Plasma Separation and Adsorption). Пациенты и методы. За период с января 2019-го по май 2020 года было выполнено 139 трансплантаций печени детям. Были проанализированы данные 5 пациентов детского возраста (2 девочки и 3 мальчика в возрасте 12–17 лет), получавших сеансы сепарации и адсорбции фракционированной плазмы (САФП) в качестве моста к трансплантации. Главным клиническим показанием к проведению САФП являлась выраженная печеночная энцефалопатия (3-я степень по шкале West-Haven), отмечавшаяся при сывороточном уровне билирубина 350–872 (в среднем 597 ± 98 мкмоль/л). Сеансы САФП проводились на аппарате Prometheus с использованием гемофильтров AV 600 в качестве диализаторов (Fresenius Medical Care, Germany). Результаты. В зависимости от величины билирубинемии у пациентов потребовалось от одного (в одном случае) до трех (в одном случае) ежедневных сеансов САФП для восстановления ясного сознания, аппетита и физической активности. Средний уровень билирубина после циклов лечения снизился с 597 ± 98 до 236 ± 73 мкмоль/л. Всем больным в сроки от двух до пяти дней была проведена успешная трансплантация печени, в двух случаях – трансплантация фрагмента печени от живого родственного донора. Заключение. Применение системы САФП позволяет стабилизировать состояние потенциальных реципиентов с выраженной печеночной недостаточностью. Для отработки оптимальных режимов использования альбуминового диализа требуются дальнейшие исследования.</p></abstract><trans-abstract xml:lang="en"><p>Liver transplantation is the only effective treatment modality for end-stage liver disease. However, donor organs are not always available. In some cases, the gravity of the patient’s condition makes transplantation impossible. In this regard, the use of artificial liver support systems helps in preparing a patient for transplant surgery. Objective: to conduct a retrospective study aimed at evaluating the efficiency of fractionated plasma separation and adsorption system. Materials and methods. From January 2019 to May 2020, 139 pediatric liver transplants were. We analyzed the data of 5 pediatric patients (2 girls and 3 boys, aged 12 to 17 years) who received fractionated plasma separation and adsorption (FPSA) sessions as a bridge to transplantation. The main clinical indication for FPSA was severe hepatic encephalopathy (grade 3 according to the West Haven Criteria), which was observed at 350–872 μmol/L (average 597 ± 98 μmol/L) serum bilirubin level. The FPSA sessions were conducted on a Prometheus device using AV-600 hemofilters as dialyzers (Fresenius Medical Care, Germany). Results. Depending on the extent of bilirubinemia in patients, it took from one (in one case) to three (in one case) daily FPSA sessions to restore clear consciousness, appetite and physical activity. Average bilirubin levels after treatment cycles decreased from 597 ± 98 to 236 ± 73 μmol/L. All patients successfully underwent liver transplant surgery within two to five days, two patients received a liver fragment from a living related donor. Conclusion. The FPSA system stabilizes the condition of potential recipients with acute liver failure. Further research is required to develop optimal regimens for albumin dialysis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цирроз печени</kwd><kwd>печеночная недостаточность</kwd><kwd>альбуминовый диализ</kwd><kwd>трансплантация печени</kwd><kwd>детская трансплантация печени</kwd><kwd>экстракорпоральная детоксикация</kwd><kwd>печеночная энцефалопатия</kwd><kwd>сепарация и адсорбции фракционированной плазмы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cirrhosis</kwd><kwd>liver failure</kwd><kwd>albumin dialysis</kwd><kwd>liver transplantation</kwd><kwd>pediatric liver transplantation</kwd><kwd>extracorporeal liver support</kwd><kwd>hepatic encephalopathy</kwd><kwd>fractionated plasma separation and adsorption</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Saliba F, Samuel D. Artificial liver support: a real step forward. 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