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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2020-1-118-122</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1152</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Применение левосимендана при трансплантации легких в условиях ВА ЭКМО</article-title><trans-title-group xml:lang="en"><trans-title>Levosimendan in lung transplant recipients on VA‑ECMO</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавель</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravel</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Журавель Сергей Владимирович.</p><p>129090, Москва, Б. Сухаревская пл., д. 3.</p></bio><bio xml:lang="en"><p>Zhuravel’ Sergey Vladimirovich.</p><p>3, Bolshaya Sukharevskaya sq., Moscow, 129090</p></bio><email xlink:type="simple">zhsergey5@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александрова</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleksandrova</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уткина</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Utkina</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарабрин</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarabrin</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>22</day><month>04</month><year>2020</year></pub-date><volume>22</volume><issue>1</issue><fpage>118</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Журавель С.В., Александрова В.Э., Уткина И.И., Кузнецова Н.К., Тарабрин Е.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Журавель С.В., Александрова В.Э., Уткина И.И., Кузнецова Н.К., Тарабрин Е.А.</copyright-holder><copyright-holder xml:lang="en">Zhuravel S.V., Aleksandrova V.E., Utkina I.I., Kuznetsova N.K., Tarabrin E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1152">https://journal.transpl.ru/vtio/article/view/1152</self-uri><abstract><p>Одним из наиболее грозных осложнений в раннем послеоперационном периоде после трансплантации легких является развитие сердечно-сосудистой недостаточности. В то же время опыт применения левосимендана в раннем периоде после трансплантации легких в настоящее время незначителен и остается дискуссионным. Представлен клинический случай успешного применения левосимендана у пациента с правожелудочковой сердечной недостаточностью при трансплантации легких в условиях использования центральной вено-артериальной экстракорпоральной мембранной оксигенации (ВА ЭКМО).</p></abstract><trans-abstract xml:lang="en"><p>Chronic heart failure is one of the most dreadful complications in the early postoperative period following lung transplantation. At the same time, the effect of using levosimendan in the early post-lung transplant period is currently insignificant and remains debatable. This paper presents a clinical case where levosimendan was successfully used in a patient with right ventricular heart failure during lung transplantation undergoing central venoarterial extracorporeal membrane oxygenation (VA-ECMO).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>левосимендан</kwd><kwd>трансплантация легких</kwd><kwd>правожелудочковая сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>levosimendan</kwd><kwd>lung transplantation</kwd><kwd>right ventricular heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation. 2005; 112: 154–235.</mixed-citation><mixed-citation xml:lang="en">Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation. 2005; 112: 154–235.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Forrest P. Anaesthesia and right ventricular failure. Anaesth Intensive Care. 2009 May; 37 (3): 370–385.</mixed-citation><mixed-citation xml:lang="en">Forrest P. Anaesthesia and right ventricular failure. Anaesth Intensive Care. 2009 May; 37 (3): 370–385.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Carillo C, Pecoraro Y, Anile M, Mantovani S, Oliva A, D’Abramo A et al. Evaluation of Renal Function in Patients Undergoing Lung Transplantation. Transplant Proc. 2017 May; 49 (4): 699–701. doi: 10.1016/j.transproceed.2017.02.036.</mixed-citation><mixed-citation xml:lang="en">Carillo C, Pecoraro Y, Anile M, Mantovani S, Oliva A, D’Abramo A et al. Evaluation of Renal Function in Patients Undergoing Lung Transplantation. Transplant Proc. 2017 May; 49 (4): 699–701. doi: 10.1016/j.transproceed.2017.02.036.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sher Y, Mooney J, Dhillon G, Lee R, Maldonado JR. Delirium after lung transplantation: Association with recipient characteristics, hospital resource utilization, and mortality. Clin Transplant. 2017 May; 31 (5). doi: 10.1111/ctr.12966. Epub 2017 Apr 11.</mixed-citation><mixed-citation xml:lang="en">Sher Y, Mooney J, Dhillon G, Lee R, Maldonado JR. Delirium after lung transplantation: Association with recipient characteristics, hospital resource utilization, and mortality. Clin Transplant. 2017 May; 31 (5). doi: 10.1111/ctr.12966. Epub 2017 Apr 11.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng TZ, Choi KJ, Honeybrook AL, Zakare-Fagbamila RT, Gray AL, Snyder LD et al. Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation. Am J Rhinol Allergy. 2019 July; 33 (4): 354–358. doi: 10.1177/1945892419830624.</mixed-citation><mixed-citation xml:lang="en">Cheng TZ, Choi KJ, Honeybrook AL, Zakare-Fagbamila RT, Gray AL, Snyder LD et al. Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation. Am J Rhinol Allergy. 2019 July; 33 (4): 354–358. doi: 10.1177/1945892419830624.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Missant C, Rex S, Segers P, Wouters PF. Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction. Crit Care Med. 2007; 35: 707–715.</mixed-citation><mixed-citation xml:lang="en">Missant C, Rex S, Segers P, Wouters PF. Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction. Crit Care Med. 2007; 35: 707–715.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bartolome SD, Torres F. Severe pulmonary arterial hypertension: stratification of medical therapies, mechanical support, and lung transplantation. Heart Fail Rev. 2016; 21 (3): 347–356. doi: 10.1007/s10741-016-9562‑7.</mixed-citation><mixed-citation xml:lang="en">Bartolome SD, Torres F. Severe pulmonary arterial hypertension: stratification of medical therapies, mechanical support, and lung transplantation. Heart Fail Rev. 2016; 21 (3): 347–356. doi: 10.1007/s10741-016-9562-7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Leather HA, Ver Eycken K, Segers P, Herijgers P, Vandermeersch E, Wouters PF. Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. Crit Care Med. 2003; 31: 2339– 2343.</mixed-citation><mixed-citation xml:lang="en">Leather HA, Ver Eycken K, Segers P, Herijgers P, Vandermeersch E, Wouters PF. Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. Crit Care Med. 2003; 31: 2339– 2343.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cavusoglu Y, Beyaztas A, Birdane A, Ata N. Levosimendan and pulmonary hypertension. J Cardiovasc Med (Hagerstown). 2010 Jul; 11 (7): 478–480. doi: 10.2459/JCM.0b013e32833a0a0b.</mixed-citation><mixed-citation xml:lang="en">Cavusoglu Y, Beyaztas A, Birdane A, Ata N. Levosimendan and pulmonary hypertension. J Cardiovasc Med (Hagerstown). 2010 Jul; 11 (7): 478–480. doi: 10.2459/JCM.0b013e32833a0a0b.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cavusoglu Y, Tek M, Birdane A, Ata N, Demirustu C, Gorenek B et al. Both levosimendan and dobutamine treatments result in significant reduction of NT-proBNP levels, but levosimendan has better and prolonged neurohormonal effects than dobutamine. Int J Cardiol. 2008; 127: e188–e191.</mixed-citation><mixed-citation xml:lang="en">Cavusoglu Y, Tek M, Birdane A, Ata N, Demirustu C, Gorenek B et al. Both levosimendan and dobutamine treatments result in significant reduction of NT-proBNP levels, but levosimendan has better and prolonged neurohormonal effects than dobutamine. Int J Cardiol. 2008; 127: e188–e191.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chanchlani R, Joseph Kim S, Kim ED, Banh T, Borges K, Vasilevska-Ristovska J et al. Incidence of hyperglycemia and diabetes and association with electrolyte abnormalities in pediatric solid organ transplant recipients. Nephrol Dial Transplant. 2017 Sep; 32 (9): 1579–1586. Published online 2017 Jul 27. doi: 10.1093/ndt/gfx205.</mixed-citation><mixed-citation xml:lang="en">Chanchlani R, Joseph Kim S, Kim ED, Banh T, Borges K, Vasilevska-Ristovska J et al. Incidence of hyperglycemia and diabetes and association with electrolyte abnormalities in pediatric solid organ transplant recipients. Nephrol Dial Transplant. 2017 Sep; 32 (9): 1579–1586. Published online 2017 Jul 27. doi: 10.1093/ndt/gfx205.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Хубутия МШ, Тарабрин ЕА, Журавель СВ и др. Опыт применения экстракорпоральной мембранной оксигенации для обеспечения двусторонней трансплантации легких. Вестник трансплантологии и искусственных органов. 2014; 2: 66–74.</mixed-citation><mixed-citation xml:lang="en">Khubutiya MSh, Tarabrin EA, Zhuravel’ SV i dr. Opyt primeneniya ekstrakorporal’noy membrannoy oksigenatsii dlya obespecheniya dvustoronney transplantatsii legkikh. Vestnik transplantologii i iskusstvennykh organov. 2014; 2: 66–74.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hoeper MM, Benza RL, Corris P, de Perrot M, Fadel E, Keogh AM et al. Intensive care, right ventricular support and lung transplantation in patients with pulmonary hypertension. Eur Respir J. 2019 Jan; 53 (1): 1801906. doi: 10.1183/13993003.01906-2018.</mixed-citation><mixed-citation xml:lang="en">Hoeper MM, Benza RL, Corris P, de Perrot M, Fadel E, Keogh AM et al. Intensive care, right ventricular support and lung transplantation in patients with pulmonary hypertension. Eur Respir J. 2019 Jan; 53 (1): 1801906. doi: 10.1183/13993003.01906-2018.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sundberg S, Lilleberg J, Nieminen MS et al. Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men. Am J Cardiol. 1995; 75: 1061–1066.</mixed-citation><mixed-citation xml:lang="en">Sundberg S, Lilleberg J, Nieminen MS et al. Hemodynamic and neurohumoral effects of levosimendan, a new calcium sensitizer, at rest and during exercise in healthy men. Am J Cardiol. 1995; 75: 1061–1066.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Leather HA, Ver Eycken K, Segers P et al. Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. Crit Care Med. 2003; 31: 2339–2343.</mixed-citation><mixed-citation xml:lang="en">Leather HA, Ver Eycken K, Segers P et al. Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. Crit Care Med. 2003; 31: 2339–2343.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sonntag S, Sundberg S, Lehtonen LA, Kleber FX. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. JACC. 2004; 43: 2177–2182.</mixed-citation><mixed-citation xml:lang="en">Sonntag S, Sundberg S, Lehtonen LA, Kleber FX. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. JACC. 2004; 43: 2177–2182.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
