<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2019-4-143-146</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1116</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Современное состояние проблемы и результаты ex vivo перфузии донорских сердец</article-title><trans-title-group xml:lang="en"><trans-title>Current state of the problem and results of ex vivo perfusion of donor hearts</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жульков</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhulkov</surname><given-names>M. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центр хирургии аорты, коронарных и периферических артерий.</p><p>Жульков Максим Олегович.</p><p>630055, Новосибирск, ул. Речкуновская, д. 15.Тел. (906) 909-05-05</p></bio><bio xml:lang="en"><p>Center for Surgery of the Aorta, Coronary and Peripheral Arteries.</p><p>Zhulkov Maxim Olegovich</p><p>15, Rechkunovskaya str., Novosibirsk, 630055.Tel. (906) 909-05-05</p></bio><email xlink:type="simple">maks.zhulkov.92@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомичев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomichev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центр хирургии аорты, коронарных и периферических артерий.</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Center for Surgery of the Aorta, Coronary and Peripheral Arteries.</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Альсов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alsov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центр хирургии аорты, коронарных и периферических артерий.</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Center for Surgery of the Aorta, Coronary and Peripheral Arteries.</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кливер</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Cleaver</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центр хирургии аорты, коронарных и периферических артерий.</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Center for Surgery of the Aorta, Coronary and Peripheral Arteries.</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернявский</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyavsky</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центр хирургии аорты, коронарных и периферических артерий.</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Center for Surgery of the Aorta, Coronary and Peripheral Arteries.</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Meshalkin National Medical Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>02</day><month>02</month><year>2020</year></pub-date><volume>21</volume><issue>4</issue><fpage>143</fpage><lpage>146</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жульков М.О., Фомичев А.В., Альсов С.А., Кливер Е.Н., Чернявский А.М., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Жульков М.О., Фомичев А.В., Альсов С.А., Кливер Е.Н., Чернявский А.М.</copyright-holder><copyright-holder xml:lang="en">Zhulkov M.O., Fomichev A.V., Alsov S.A., Cleaver E.N., Chernyavsky A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1116">https://journal.transpl.ru/vtio/article/view/1116</self-uri><abstract><p>Больные с терминальной сердечной недостаточностью, рефрактерной к медикаментозной терапии, являются тяжелой категорией кардиологических больных. Многочисленные исследования доказали наибольшую эффективность трансплантации сердца по сравнению с другими методами лечения терминальной стадии хронической сердечной недостаточности. Однако несмотря на десятилетия развития трансплантологии, вопрос нехватки донорских органов остается открытым. Единственным способом сократить нехватку донорских органов является использование доноров с расширенными критериями, что требует использования самых последних технологий в области реанимации и кондиционировании органов.</p></abstract><trans-abstract xml:lang="en"><p>Patients with drug refractory end-stage heart failure fall into the severe category of cardiological patients. Numerous studies have shown the superior efficacy of heart transplantation over other treatments for end-stage chronic heart failure. However, despite decades of achievements in transplantology, shortage of donor organs remains a pressing and unresolved issue. The only way to reduce shortage of donor organs is to use donors with advanced criteria, which requires the use of latest technologies in organ resuscitation and conditioning.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечная недостаточность</kwd><kwd>трансплантация сердца</kwd><kwd>перфузия ex vivo</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart failure</kwd><kwd>heart transplantation</kwd><kwd>ex vivo perfusion</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. World Health Statistics 2016: Monitoring Health for the SDGs Annex B: Tables of Health Statistics by Country, WHO Region and Globally [Internet]. 2016.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. World Health Statistics 2016: Monitoring Health for the SDGs Annex B: Tables of Health Statistics by Country, WHO Region and Globally [Internet]. 2016.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013; 6: 606–619.</mixed-citation><mixed-citation xml:lang="en">Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013; 6: 606–619.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Messer S, Ardehali A, Tsui S. Normothermic donor heart perfusion: current clinical experience and the future. Transplant International. 2015; 28 (6): 634–642.</mixed-citation><mixed-citation xml:lang="en">Messer S, Ardehali A, Tsui S. Normothermic donor heart perfusion: current clinical experience and the future. Transplant International. 2015; 28 (6): 634–642.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Blood N.H.S. Transplant. Organ Donation and Transplantation activity figures for the UK as at 12 April 2013. – 2014.</mixed-citation><mixed-citation xml:lang="en">Blood N.H.S. Transplant. Organ Donation and Transplantation activity figures for the UK as at 12 April 2013. – 2014.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Canadian Institute for Health Information. Canadian Organ Replacement Register Annual Report: Treatment of End-Stage Organ Failure in Canada, 2004 to 2013. Ottawa, ON: Canadian Institute for Health Information; (2015).</mixed-citation><mixed-citation xml:lang="en">Canadian Institute for Health Information. Canadian Organ Replacement Register Annual Report: Treatment of End-Stage Organ Failure in Canada, 2004 to 2013. Ottawa, ON: Canadian Institute for Health Information; (2015).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Barnard CN. Human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. South African Medical Journal. 1967; 41 (48): 1271–1274.</mixed-citation><mixed-citation xml:lang="en">Barnard CN. Human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. South African Medical Journal. 1967; 41 (48): 1271–1274.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rudge C, Matesanz R, Delmonico FL, Chapman J. International practices of organ donation. Br J Anaesthesia. 2012; 108 (S1): i48–i55.</mixed-citation><mixed-citation xml:lang="en">Rudge C, Matesanz R, Delmonico FL, Chapman J. International practices of organ donation. Br J Anaesthesia. 2012; 108 (S1): i48–i55.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Citerio G, Cypel M, Dobb GJ et al. Organ donation in adults: a critical care perspective. Intensive Care Med. 2016; 42: 305–315.</mixed-citation><mixed-citation xml:lang="en">Citerio G, Cypel M, Dobb GJ et al. Organ donation in adults: a critical care perspective. Intensive Care Med. 2016; 42: 305–315.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Costanzo MR, Dipchand A, Starling R, Anderson A, Chan M, Desai S et al. Task Force 1: peri-operative care of the heart transplant patient. In: the International Society of Heart and Lung Transplantation guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010 Aug; 29 (8): 915–926.</mixed-citation><mixed-citation xml:lang="en">Costanzo MR, Dipchand A, Starling R, Anderson A, Chan M, Desai S et al. Task Force 1: peri-operative care of the heart transplant patient. In: the International Society of Heart and Lung Transplantation guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010 Aug; 29 (8): 915–926.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Banner NR, Thomas HL, Curnow E et al. The importance of cold and warm cardiac ischemic for survival after heart transplantation. Steering Group of the United Kingdom Cardiothoracic.</mixed-citation><mixed-citation xml:lang="en">Banner NR, Thomas HL, Curnow E et al. The importance of cold and warm cardiac ischemic for survival after heart transplantation. Steering Group of the United Kingdom Cardiothoracic.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Transplant Audit. Transplantation. 2008; 86: 542–547.</mixed-citation><mixed-citation xml:lang="en">Transplant Audit. Transplantation. 2008; 86: 542–547.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Russo MJ, Iribarne A, Hong KN et al. Factors associated with primary allograft failure after heart transplantation. Transplantation. 2010; 90: 444–450.</mixed-citation><mixed-citation xml:lang="en">Russo MJ, Iribarne A, Hong KN et al. Factors associated with primary allograft failure after heart transplantation. Transplantation. 2010; 90: 444–450.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hertz MI, Aurora P, Christie JD et al. Scientific Registry of the International Society for Heart and Lung Transplantation: introduction to the 2009 annual reports. J Heart Lung Transplant. 2009; 28: 989–992.</mixed-citation><mixed-citation xml:lang="en">Hertz MI, Aurora P, Christie JD et al. Scientific Registry of the International Society for Heart and Lung Transplantation: introduction to the 2009 annual reports. J Heart Lung Transplant. 2009; 28: 989–992.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Schnitzler MA, Hauptman PJ, Takemoto SK et al. The impact of cold ischaemia time on life year benefit of heart transplantation. Am J Transplant. 2006; 6: 382.</mixed-citation><mixed-citation xml:lang="en">Schnitzler MA, Hauptman PJ, Takemoto SK et al. The impact of cold ischaemia time on life year benefit of heart transplantation. Am J Transplant. 2006; 6: 382.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kobashigawa J, Zuckermann A, Macdonald P et al. Consensus Conference Participants. Report from a consensus conference on primary graft dysfunction after cardiac transplantation. J Heart Lung Transplant. 2014; 33: 327–340.</mixed-citation><mixed-citation xml:lang="en">Kobashigawa J, Zuckermann A, Macdonald P et al. Consensus Conference Participants. Report from a consensus conference on primary graft dysfunction after cardiac transplantation. J Heart Lung Transplant. 2014; 33: 327–340.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sáez DG et al. Evaluation of the organ care system in heart transplantation with an adverse donor/recipient profile. The Annals of thoracic surgery. 2014; 98 (6): 2099–2106.</mixed-citation><mixed-citation xml:lang="en">Sáez DG et al. Evaluation of the organ care system in heart transplantation with an adverse donor/recipient profile. The Annals of thoracic surgery. 2014; 98 (6): 2099–2106.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Del Riozz DF, Menkis AH, Pflugfelder PW, Novick RJ, McKenzie FN, Boyd WD, Kostul WJ. The role of donor age and ischemic time on survival following orthotopic heart transplantation. J Heart Lung Transplant. 1999; 18: 310–319.</mixed-citation><mixed-citation xml:lang="en">Del Riozz DF, Menkis AH, Pflugfelder PW, Novick RJ, McKenzie FN, Boyd WD, Kostul WJ. The role of donor age and ischemic time on survival following orthotopic heart transplantation. J Heart Lung Transplant. 1999; 18: 310–319.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Iyer A, Gao L, Doyle A et al. Normothermic ex vivo perfusion provides superior preservation and enables viability assessment of hearts from DCD donors. Am J Transplant. 2015; 15: 371–380.</mixed-citation><mixed-citation xml:lang="en">Iyer A, Gao L, Doyle A et al. Normothermic ex vivo perfusion provides superior preservation and enables viability assessment of hearts from DCD donors. Am J Transplant. 2015; 15: 371–380.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Zaroff JG, Rosengard BR, Armstrong WF et al. Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations: March 28–29, 2001, Crystal City, Va. Circulation 2002; 106: 836–841.</mixed-citation><mixed-citation xml:lang="en">Zaroff JG, Rosengard BR, Armstrong WF et al. Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations: March 28–29, 2001, Crystal City, Va. Circulation 2002; 106: 836–841.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Costanzo MR, Dipchand A, Starling R et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010; 29: 914–956.</mixed-citation><mixed-citation xml:lang="en">Costanzo MR, Dipchand A, Starling R et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010; 29: 914–956.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Esmailian F et al. The PROCEED II international heart transplant trial with the organ care system technology (OCS). The Journal of Heart and Lung Transplantation. 2013; 32 (4): S95–S96.</mixed-citation><mixed-citation xml:lang="en">Esmailian F et al. The PROCEED II international heart transplant trial with the organ care system technology (OCS). The Journal of Heart and Lung Transplantation. 2013; 32 (4): S95–S96.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Cypel M, Yeung JC, Machuca T et al. Experience with the first 50 ex vivo lung perfusions in clinical transplantation. J Thorac Cardiovasc Surg. 2012; 144: 1200–1206.</mixed-citation><mixed-citation xml:lang="en">Cypel M, Yeung JC, Machuca T et al. Experience with the first 50 ex vivo lung perfusions in clinical transplantation. J Thorac Cardiovasc Surg. 2012; 144: 1200–1206.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ghodsizad A, Bordel V, Ungerer M et al. Ex vivo coronary angiography of a donor heart in the organ care system. Heart Surg Forum. 2012; 15: E161–3.</mixed-citation><mixed-citation xml:lang="en">Ghodsizad A, Bordel V, Ungerer M et al. Ex vivo coronary angiography of a donor heart in the organ care system. Heart Surg Forum. 2012; 15: E161–3.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Scholar T. The Chironian Vol. 22 No. – 1960.</mixed-citation><mixed-citation xml:lang="en">Scholar T. The Chironian Vol. 22 No. – 1960.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Quader MA, Wolfe LG, Kasirajan V. Heart transplantation outcomes from cardiac arrest-resuscitated donors. Heart Lung Transplant. 2013; 32: 1090–1095.</mixed-citation><mixed-citation xml:lang="en">Quader MA, Wolfe LG, Kasirajan V. Heart transplantation outcomes from cardiac arrest-resuscitated donors. Heart Lung Transplant. 2013; 32: 1090–1095.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tikkanen JM, Cypel M, Machuca TN et al. Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation. J Heart Lung Transplant. 2015; 34: 547–556.</mixed-citation><mixed-citation xml:lang="en">Tikkanen JM, Cypel M, Machuca TN et al. Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation. J Heart Lung Transplant. 2015; 34: 547–556.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Page A et al. Early outcomes from DCD heart transplantation: a single centre experience. The Journal of Heart and Lung Transplantation. 2018; 37 (4): S13–S14.</mixed-citation><mixed-citation xml:lang="en">Page A et al. Early outcomes from DCD heart transplantation: a single centre experience. The Journal of Heart and Lung Transplantation. 2018; 37 (4): S13–S14.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">The National Institute for Health and Care Excellence. OCS Heart System for Heart Transplant, Medtech Innovation Briefing. https://www.nice.org.uk/advice/mib86/resources/ocs-heart-system-for-heart-transplantpdf63499411285189 (30 August 2018, date last accessed).</mixed-citation><mixed-citation xml:lang="en">The National Institute for Health and Care Excellence. OCS Heart System for Heart Transplant, Medtech Innovation Briefing. https://www.nice.org.uk/advice/mib86/resources/ocs-heart-system-for-heart-transplantpdf63499411285189 (30 August 2018, date last accessed).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Messer S, Page A, Axell R, Berman M, Hernández-Sánchez J, Colah S et al. Outcome after heart transplantation from donation after circulatorydetermined death donors. J Heart Lung Transplant. 2017; 36: 1311–1318.</mixed-citation><mixed-citation xml:lang="en">Messer S, Page A, Axell R, Berman M, Hernández-Sánchez J, Colah S et al. Outcome after heart transplantation from donation after circulatorydetermined death donors. J Heart Lung Transplant. 2017; 36: 1311–1318.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
