References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2019-3-151-165

vtio-1074

Research Article

Обзор литературы

Literature Reviews

Цитомегаловирусная инфекция после трансплантации почки: реальные достижения и перспективы изучения патогенеза, профилактики и лечения

Cytomegalovirus infection after kidney transplantation: real progress and prospects for pathogenesis research, prevention and treatment

Прокопенко

Е. И.

Prokopenko

E. I.

Прокопенко Елена Ивановна. Адрес: 129110, Москва, ул. Щепкина, д. 61/2. Тел. (495) 684-57-91.

Prokopenko Elena Ivanovna. Address: 61/2, Shchepkina str., Moscow, 129110. Теl. (495) 684-57-91.

renalnephron@gmail.com

ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского»РоссияM.F. Vladimirsky Moscow Regional Research Clinical InstituteRussian Federation

2019

01102019

213151165

2019

Прокопенко Е.И.

Prokopenko E.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/1074

Цитомегаловирусная (ЦМВ) инфекция играет важную роль в клинической трансплантологии, поскольку повышает риск развития осложнений, потери трансплантатов, смерти пациентов. Вирус обладает как прямыми (непосредственное повреждение органов и тканей), так и непрямыми иммуномодулирующими эффектами. Международная группа экспертов на основании проведенных исследований разработала общие принципы ведения ЦМВ-инфекции после трансплантации. В статье рассматриваются факторы риска, патогенетические механизмы развития ЦМВ-инфекции после трансплантации почки, принципы диагностики, лечения и профилактики данного осложнения, пути преодоления лекарственной устойчивости вируса. Обсуждаются перспективы применения иммунологического мониторинга, новых противовирусных препаратов, а также возможность использования ЦМВ-вакцин, T-клеточной терапии, иммуносупрессантов – ингибиторов mTOR, обладающих противовирусным действием.

Cytomegalovirus (CMV) infection plays an important role in clinical transplantology – it increases the risk of complications, graft failure, and patient death. The virus has both direct (direct damage to organs and tissues) and indirect immunomodulatory effects. Based on studies conducted, an international group of experts developed general principles for managing CMV infection after transplantation. This paper discusses risk factors, pathogenetic mechanisms by which CMV infection develops after kidney transplantation, the principles of diagnosis, treatment and prevention of this complication, and ways to overcome drug resistance in the virus. The prospects for the use of immunological monitoring, new antiviral drugs, as well as the possibility of using CMV vaccines, T-cell therapy, immunosuppressants (antiviral mTOR inhibitors) are discussed.

цитомегаловирусная инфекциятрансплантация почкипотеря трансплантаталетальностьпротивовирусная профилактикаингибиторы mTOR

cytomegalovirus infectionkidney transplantgraft failuremortalityantiviral prophylaxismTOR inhibitors

Е.И. Прокопенко участвовала в качестве лектора в образовательных программах компаний «Рош» и «Новартис».

The author participated as a speaker in educational programs for Roche and Novartis.

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The authors declare that there are no conflicts of interest present.