References

vtio

Вестник трансплантологии и искусственных органов

Russian Journal of Transplantology and Artificial Organs

1995-1191

Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation

10.15825/1995-1191-2019-3-141-150

vtio-1073

Research Article

Обзор литературы

Literature Reviews

Возможности получения и применения биоматериалов на основе гидрогелей для регенерации костной ткани человека

Possibilities of obtaining and using hydrogel-based biomaterials for regeneration of human bone tissue

Дубров

В. Э.

Dubrov

V. E.

Дубров Вадим Эрикович. Адрес: 119991, Россия, Москва, Ломоносовский пр-т, д. 27, корп. 1. Тел. (985) 764-52-89.

Dubrov Vadim Erikovich. Address: 27, Lomonosov av., Moscow, 119991. Теl. (985) 764-52-89.

vduort@gmail.com

Климашина

Е. С.

Klimashina

E. S.

Щербаков

И. М.

Scherbakov

I. M.

Шипунов

Г. А.

Shipunov

G. A.

Путляев

В. И.

Putlayev

V. I.

Евдокимов

П. В.

Evdokimov

P. V.

Тихонов

А. А.

Tikhonov

A. A.

Гулько

С. В.

Gulko

S. V.

Зюзин

Д. А.

Zyuzin

D. A.

ФГОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияFederal State-Funded Educational Institution of Higher Education «Lomonosov Moscow State University»Russian Federation

2019

01102019

213141150

2019

Дубров В.Э., Климашина Е.С., Щербаков И.М., Шипунов Г.А., Путляев В.И., Евдокимов П.В., Тихонов А.А., Гулько С.В., Зюзин Д.А.

Dubrov V.E., Klimashina E.S., Scherbakov I.M., Shipunov G.A., Putlayev V.I., Evdokimov P.V., Tikhonov A.A., Gulko S.V., Zyuzin D.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.transpl.ru/vtio/article/view/1073

Проблема замещения дефектов различных тканей, в особенности костной, стоит остро в современной медицине. Лишенного недостатков универсального метода их заполнения в настоящее время не существует. Одной из перспективных групп аллопластических материалов являются гидрогели. В настоящее время с помощью различных методов химической и физической модификации из них удается получать материалы с различными биологическими свойствами, позволяющими приближать их к натуральному экстрацеллюлярному матриксу и использовать как средство доставки стволовых клеток и биологически активных веществ в зону дефекта. Рассмотрению различных аспектов получения и применения биологических материалов из гидрогелей и посвящен данный обзор литературы.

Substitution of defects in various tissues, especially bone tissues, is a major challenge in modern medicine. There is currently no universal method of filling defects which has no drawbacks. Hydrogels are one of the promising groups of alloplastic materials. At present, you can obtain materials with various biological properties like natural extracellular matrix using various methods of chemical and physical modification. These biomaterials can be used as a means of delivering stem cells and bioactive substances to the defect zone. This literature review is devoted to the various aspects of preparation and use of hydrogel-based biological materials.

гидрогелирегенерация тканейтканевая инженерия

hydrogelstissue regenerationtissue engineering

Работа выполнена при поддержке РНФ (грант № 17-79-20427).

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The authors declare that there are no conflicts of interest present.