vtioВестник трансплантологии и искусственных органовRussian Journal of Transplantology and Artificial Organs1995-1191Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation10.15825/1995-1191-2019-2-138-144vtio-1030Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSМикро-РНК у реципиентов легких: перспективы клинического примененияMicro-RNA in lung transplant recipients: the prospects of clinical applicationВеликийД. А.VelikiyD. A.

Москва

Moscow

ШарапченкоС. О.SharapchenkoS. O.

Шарапченко Софья Олеговна

123182, Москва, ул. Щукинская, д. 1, Тел. (495) 190-35-62

Sharapchenko Sofya Olegovna

1, Shchukinskaya str., Moscow, 123182, Tel. (495) 190-35-62

livertranspl@mail.ruПашковИ. В.PashkovI. V.

Москва

Moscow

ГичкунО. Е.GichkunO. E.

Moscow

ШевченкоО. П.ShevchenkoO. P.ФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава РоссииРоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationRussian FederationФГБУ «Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)РоссияV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)Russian Federation201911072019212138144Copyright © Великий Д.А., Шарапченко С.О., Пашков И.В., Гичкун О.Е., Шевченко О.П., 20192019Великий Д.А., Шарапченко С.О., Пашков И.В., Гичкун О.Е., Шевченко О.П.Velikiy D.A., Sharapchenko S.O., Pashkov I.V., Gichkun O.E., Shevchenko O.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.transpl.ru/vtio/article/view/1030

Обзор литературы посвящен исследованиям биомаркеров, потенциально пригодных для диагностики отторжения трансплантированных легких. В настоящее время большой интерес вызывает изучение малых некодирующих РНК (микро-РНК), регулирующих экспрессию генов и влияющих на различные функции клетки. Были показаны изменения концентрации некоторых микро-РНК при различных патологических процессах, в том числе при отторжении солидных органов. Оценка уровней микро-РНК при трансплантации легких может иметь значение для оценки риска развития отторжения и подбора иммуносупрессивной терапии. Накопление клинических данных о связи профилей различных биомаркеров с клиническими и лабораторными показателями у реципиентов легких поможет в поиске неинвазивных методов диагностики отторжения и улучшении отдаленных результатов трансплантации.

This review summarizes the current literature devoted to the analysis of diagnostic role of biomarkers in rejection of the transplanted lung. Numerous researches have focused on small non-coding RNAs (micro-RNA) that regulate gene expression and affect various cell functions. Variations in the concentration of different micro-RNA have been shown in some pathological processes, including rejection of solid organs. Probably, measuring the level of micro-RNA in lung transplant may have value in the assessment of risk of rejection and possibility of minimizing immunosuppressive therapy. The accumulation of clinical data on the correlation of profiles of various biomarkers with clinical and laboratory parameters in lung recipients will help in finding non-invasive methods for the diagnosis rejection and improving long-term results of transplantation.

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The authors declare that there are no conflicts of interest present.