<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vtio</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник трансплантологии и искусственных органов</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Transplantology and Artificial Organs</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-1191</issn><publisher><publisher-name>Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15825/1995-1191-2019-2-121-124</article-id><article-id custom-type="elpub" pub-id-type="custom">vtio-1028</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL REPORTS</subject></subj-group></article-categories><title-group><article-title>Регрессия саркомы Капоши после длительного лечения ингибиторами m-TOR и полной отмены иммуносупрессии у реципиента после трансплантации почки</article-title><trans-title-group xml:lang="en"><trans-title>Kaposi’s sarcoma regression after long term treatment of m-TOR inhibitors and cancellation of immunosuppressive therapy in patient after kidney transplantation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сапожников</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Sapozhnikov</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сапожников Аркадий Давидович</p><p>404120, Волгоградская область, Волжский, ул. им. генерала Карбышева, д. 86, Тел. (8443) 27-44-77</p></bio><bio xml:lang="en"><p>Sapozhnikov Arkady Davidovich</p><p>86, General Karbishev Str., Volzhsky city, Volgograd reg., 404120, Tel. (8443) 27-44-77</p></bio><email xlink:type="simple">dvperlin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перлина</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Perlina</surname><given-names>A. D.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дымков</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dymkov</surname><given-names>I. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd state medical University of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ МО Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.F. Vladimirsky Moscow Regional Research Clinical Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>11</day><month>07</month><year>2019</year></pub-date><volume>21</volume><issue>2</issue><fpage>121</fpage><lpage>124</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сапожников А.Д., Перлина А.Д., Дымков И.Н., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Сапожников А.Д., Перлина А.Д., Дымков И.Н.</copyright-holder><copyright-holder xml:lang="en">Sapozhnikov A.D., Perlina A.D., Dymkov I.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.transpl.ru/vtio/article/view/1028">https://journal.transpl.ru/vtio/article/view/1028</self-uri><abstract><p>Представлен случай наблюдения пациента, у которого после трансплантации почки развилась саркома Капоши. С целью ее лечения были применены конверсия с такролимуса на эверолимус, курсы введения проспидина, в целом уменьшена напряженность иммуносупрессивной терапии. Устойчивая ремиссия достигнута лишь после удаления почечного трансплантата и полного отказа от иммуносупрессивной терапии.</p></abstract><trans-abstract xml:lang="en"><p>A case of observation of a patient who developed Kaposi’s sarcoma after kidney transplantation is presented. For the purpose of its treatment, conversion from tacrolimus to everolimus, courses of administration of prospidin were applied, in General, the intensity of immunosuppressive therapy was reduced. Stable remission was achieved only after removal of the renal transplant and complete withdrawal of immunosuppressive therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>саркома Капоши</kwd><kwd>трансплантация почки</kwd><kwd>ингибиторы кальциневрина</kwd><kwd>эверолимус</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Kaposi's sarcoma</kwd><kwd>kidney transplantation</kwd><kwd>calcineurin inhibitors</kwd><kwd>everolimus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ватазин АВ, Молочков ВА, Казанцева ИА, Щербакова ЕО, Прокопенко ЕИ, Пасов СА и др. Саркома Капоши у больных после трансплантации почки (опыт одного центра). Нефрология и диализ. 1999; 1 (2, 3): 155-163.</mixed-citation><mixed-citation xml:lang="en">Vatazin AV, Molochkov VA, Kazance-va IA, Shcherbakova EO, Prokopenko EI, Pasov SA i dr. Sarkoma Kaposhi u bol’nyh posle transplantacii pochki (opyt odnogo centra). Nefrologiya i dializ. 1999; 1 (2, 3): 155-163. [In Russ. English abstract].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cahoon EK, Linet MS, Clarke CA, Pawlish KS, Engels EA, Pfeiffer RM. Risk of Kaposi sarcoma after solid organ transplantation in the United States. Int J Cancer. 2018 Jul 10. doi: 10.1002/ijc.31735.</mixed-citation><mixed-citation xml:lang="en">Cahoon EK, Linet MS, Clarke CA, Pawlish KS, Engels EA, Pfeiffer RM. Risk of Kaposi sarcoma after solid organ transplantation in the United States. Int J Cancer. 2018 Jul 10. doi: 10.1002/ijc.31735.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gorsane I, Bacha MM, Ezzedine A, Amri N et al. Post Kidney Transplantation Kaposi’s Sarcoma: the Experience of a Mediterranean North African Center. Clin. Transplant. 2016 Jan 19. doi: 10.1111/ctr.12694.</mixed-citation><mixed-citation xml:lang="en">Gorsane I, Bacha MM, Ezzedine A, Amri N et al. Post Kidney Transplantation Kaposi’s Sarcoma: the Experience of a Mediterranean North African Center. Clin. Transplant. 2016 Jan 19. doi: 10.1111/ctr.12694.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Fritzsche FR, Tutic M, Opitz I, Hunziker R, Kristiansen G, Montani M. Pulmonary Kaposi’s sarcoma after heart transplantation: a case report. J Med Case Rep. 2010 Jul 5; 4: 206.</mixed-citation><mixed-citation xml:lang="en">Fritzsche FR, Tutic M, Opitz I, Hunziker R, Kristiansen G, Montani M. Pulmonary Kaposi’s sarcoma after heart transplantation: a case report. J Med Case Rep. 2010 Jul 5; 4: 206.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Abalo-Lojo JM, Abdulkader-Nallib I, Perez LM, Gonzalez F. Eyelid Kaposi Sarcoma in an HIV-negative Patient. Indian J Ophthalmol. 2018 Jun; 66 (6): 854-855.</mixed-citation><mixed-citation xml:lang="en">Abalo-Lojo JM, Abdulkader-Nallib I, Perez LM, Gonzalez F. Eyelid Kaposi Sarcoma in an HIV-negative Patient. Indian J Ophthalmol. 2018 Jun; 66 (6): 854-855.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Smith A, Niu W, Desai A. The Effect of Conversion from a Calcineurin Inhibitor to Sirolimus on Skin Cancer Reduction in Postrenal Transplantation Patients. Cureus. 2017 Aug 13; 9 (8): e1564.</mixed-citation><mixed-citation xml:lang="en">Smith A, Niu W, Desai A. The Effect of Conversion from a Calcineurin Inhibitor to Sirolimus on Skin Cancer Reduction in Postrenal Transplantation Patients. Cureus. 2017 Aug 13; 9 (8): e1564.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Moosa MR. Kaposi’s sarcoma in kidney transplant recipients: a 23-year experience. QJM. 2005 Mar; 98 (3): 205-214.</mixed-citation><mixed-citation xml:lang="en">Moosa MR. Kaposi’s sarcoma in kidney transplant recipients: a 23-year experience. QJM. 2005 Mar; 98 (3): 205-214.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bohelay G, Arzouk N, Levy P, Rabate C, Le Cleach L, Barete S et al. Skin and Organ Transplantation Group of the French Society of Dermatology. Outcome of second kidney transplantation in patients with previous posttransplantation Kaposi’s sarcoma: A French retrospective study. Clin Transplant. 2017 Nov; 31 (11).</mixed-citation><mixed-citation xml:lang="en">Bohelay G, Arzouk N, Levy P, Rabate C, Le Cleach L, Barete S et al. Skin and Organ Transplantation Group of the French Society of Dermatology. Outcome of second kidney transplantation in patients with previous posttransplantation Kaposi’s sarcoma: A French retrospective study. Clin Transplant. 2017 Nov; 31 (11).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
