БАЛАНС ВЗАИМОДЕЙСТВИЯ ЭФФЕКТОРНЫХ И РЕГУЛЯТОРНЫХ КЛЕТОК ПАМЯТИ КАК ОСНОВА ВЫРАБОТКИ УСТОЙЧИВОЙ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ПЕРЕСАДКЕ ОРГАНОВ (АНАЛИЗ ПРОБЛЕМЫ НА ПРИМЕРЕ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ)
https://doi.org/10.15825/1995-1191-2012-2-86-97
Аннотация
В статье представлен анализ механизмов и способов выработки иммунной толерантности в организме при воздействии антигенных нагрузок различной природы.
Показано, что состояние устойчивой толерантности достигается путем воссоздания баланса взаимодей- ствия эффекторных и регуляторных клеток во врожденной и адаптивной иммунной системе. Однако из- за высокого риска отторжения трансплантата при разных способах выработки толерантности возникает необходимость разработки надежных диагностических и прогностических методов контроля уровня и степени индивидуальной устойчивости толерантности.
Об авторах
С. Д. АртамоновД. А. Великий
Н. А. Онищенко
Л. В. Башкина
А. О. Никольская
М. Е. Крашенинников
И. М. Иванов
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Рецензия
Для цитирования:
Артамонов С.Д., Великий Д.А., Онищенко Н.А., Башкина Л.В., Никольская А.О., Крашенинников М.Е., Иванов И.М. БАЛАНС ВЗАИМОДЕЙСТВИЯ ЭФФЕКТОРНЫХ И РЕГУЛЯТОРНЫХ КЛЕТОК ПАМЯТИ КАК ОСНОВА ВЫРАБОТКИ УСТОЙЧИВОЙ ИММУННОЙ ТОЛЕРАНТНОСТИ ПРИ ПЕРЕСАДКЕ ОРГАНОВ (АНАЛИЗ ПРОБЛЕМЫ НА ПРИМЕРЕ ТРАНСПЛАНТАЦИИ ПЕЧЕНИ). Вестник трансплантологии и искусственных органов. 2012;14(2):86-97. https://doi.org/10.15825/1995-1191-2012-2-86-97
For citation:
Artamonov S.D., Velikiy D.A., Onischenko N.A., Bashkina L.V., Nikolskaya A.O., Krasheninnikov M.E., Ivanov I.M. THE BALANCE OF EFFECTORY AND REGULATORY MEMORY CELL INTERACTIONS AS A BASE FOR PRODUCING OF STEADY IMMUNE TOLERANCE STATE AFTER ORGAN TRANSPLANTATION (ANALYSIS OF PROBLEM AT THE LIVER TRANSPLANTATION EXAMPLE). Russian Journal of Transplantology and Artificial Organs. 2012;14(2):86-97. (In Russ.) https://doi.org/10.15825/1995-1191-2012-2-86-97